Beckmann rearrangement of acetophenone oximes to the corresponding amides organo-catalyzed by trifluoroacetic acid for sustainable NSAIDs synthesis

•High yield of acetaminophen and acetanilide is obtained under mild conditions.•Easy Beckmann rearrangement, easy recovery of the reagents, no work-up operation.•A sustainable process can be implemented since TFA is recycled in high extent.•TFA acts as an organocatalyst, Brønsted acid catalysis is n...

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Veröffentlicht in:	Applied catalysis. A, General General, 2014-02, Vol.472, p.167-177
Hauptverfasser:	Quartarone, Giuseppe, Rancan, Elia, Ronchin, Lucio, Vavasori, Andrea
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen Acetophenone Amides Beckmann rearrangement Catalysis Catalysts Organocatalysis Oximes Protonation Solvents Synthesis Trifluoroacetic acid
Online-Zugang:	Volltext
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