Magnetic hyaluronate hydrogels: preparation and characterization
A novel soft way of hyaluronate (HyA) based magnetic hydrogel preparation was revealed. Magnetite nanoparticles (MNPs) were prepared by co-precipitation. Since the naked MNPs cannot be dispersed homogenously in HyA-gel, their surface was modified with natural and biocompatible chondroitin-sulfate-A...
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| Veröffentlicht in: | Journal of magnetism and magnetic materials 2015-04, Vol.380, p.175-180 |
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| container_title | Journal of magnetism and magnetic materials |
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| creator | Tóth, Ildikó Y. Veress, Gábor Szekeres, Márta Illés, Erzsébet Tombácz, Etelka |
| description | A novel soft way of hyaluronate (HyA) based magnetic hydrogel preparation was revealed. Magnetite nanoparticles (MNPs) were prepared by co-precipitation. Since the naked MNPs cannot be dispersed homogenously in HyA-gel, their surface was modified with natural and biocompatible chondroitin-sulfate-A (CSA) to obtain CSA-coated MNPs (CSA@MNPs). The aggregation state of MNPs and that loaded with increasing amount of CSA up to 1mmol/g was measured by dynamic light scattering at pH~6. Only CSA@MNP with ≥0.2mmol/g CSA content was suitable for magnetic HyA-gel preparation. Rheological studies showed that the presence of CSA@MNP with up to 2g/L did not affect the hydrogel's rheological behavior significantly. The results suggest that the HyA-based magnetic hydrogels may be promising formulations for future biomedical applications, e.g. as intra-articular injections in the treatment of osteoarthritis.
•Novel hyaluronate(HyA)-based biocompatible magnetic hydrogels were prepared.•Chondroitin-sulfate-A coating is needed to disperse magnetite particles in HyA-gel.•Rheological behavior of hydrogels was independent of the magnetite content ( |
| doi_str_mv | 10.1016/j.jmmm.2014.10.139 |
| format | Article |
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•Novel hyaluronate(HyA)-based biocompatible magnetic hydrogels were prepared.•Chondroitin-sulfate-A coating is needed to disperse magnetite particles in HyA-gel.•Rheological behavior of hydrogels was independent of the magnetite content (<2g/L).•Gels remained in stable and homogeneously dispersed state even after 90 days storage.•Magnetic HyA-gels are promising candidates for use as intra-articular injection.</description><identifier>ISSN: 0304-8853</identifier><identifier>DOI: 10.1016/j.jmmm.2014.10.139</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Agglomeration ; Biocompatibility ; Biomedical materials ; Chondroitin-sulfate-A ; Coprecipitation ; Hyaluronate ; Hydrogels ; Intra-articular injection ; Loads (forces) ; Magnetic hydrogels ; Magnetism ; Magnetite ; Rheological properties ; Surface modification</subject><ispartof>Journal of magnetism and magnetic materials, 2015-04, Vol.380, p.175-180</ispartof><rights>2014 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-4b7b8d9d702f375ed5dd411bbdb00001b2ad0ed0cce08ed3e9dd165bd2bffa83</citedby><cites>FETCH-LOGICAL-c414t-4b7b8d9d702f375ed5dd411bbdb00001b2ad0ed0cce08ed3e9dd165bd2bffa83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0304885314010622$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Tóth, Ildikó Y.</creatorcontrib><creatorcontrib>Veress, Gábor</creatorcontrib><creatorcontrib>Szekeres, Márta</creatorcontrib><creatorcontrib>Illés, Erzsébet</creatorcontrib><creatorcontrib>Tombácz, Etelka</creatorcontrib><title>Magnetic hyaluronate hydrogels: preparation and characterization</title><title>Journal of magnetism and magnetic materials</title><description>A novel soft way of hyaluronate (HyA) based magnetic hydrogel preparation was revealed. Magnetite nanoparticles (MNPs) were prepared by co-precipitation. Since the naked MNPs cannot be dispersed homogenously in HyA-gel, their surface was modified with natural and biocompatible chondroitin-sulfate-A (CSA) to obtain CSA-coated MNPs (CSA@MNPs). The aggregation state of MNPs and that loaded with increasing amount of CSA up to 1mmol/g was measured by dynamic light scattering at pH~6. Only CSA@MNP with ≥0.2mmol/g CSA content was suitable for magnetic HyA-gel preparation. Rheological studies showed that the presence of CSA@MNP with up to 2g/L did not affect the hydrogel's rheological behavior significantly. The results suggest that the HyA-based magnetic hydrogels may be promising formulations for future biomedical applications, e.g. as intra-articular injections in the treatment of osteoarthritis.
•Novel hyaluronate(HyA)-based biocompatible magnetic hydrogels were prepared.•Chondroitin-sulfate-A coating is needed to disperse magnetite particles in HyA-gel.•Rheological behavior of hydrogels was independent of the magnetite content (<2g/L).•Gels remained in stable and homogeneously dispersed state even after 90 days storage.•Magnetic HyA-gels are promising candidates for use as intra-articular injection.</description><subject>Agglomeration</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Chondroitin-sulfate-A</subject><subject>Coprecipitation</subject><subject>Hyaluronate</subject><subject>Hydrogels</subject><subject>Intra-articular injection</subject><subject>Loads (forces)</subject><subject>Magnetic hydrogels</subject><subject>Magnetism</subject><subject>Magnetite</subject><subject>Rheological properties</subject><subject>Surface modification</subject><issn>0304-8853</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9UMtOwzAQ9AEkSuEHOOXIJcFOnBfiAKp4SUVcerds76Z1lMTBdpHK15O0nDnt7uzMaHcIuWE0YZQVd23S9n2fpJTxZMay-owsaEZ5XFV5dkEuvW8pnbZVsSCPH3I7YDA62h1kt3d2kAGnHpzdYufvo9HhKJ0Mxg6RHCDSu2nSAZ35OYJX5LyRncfrv7okm5fnzeotXn--vq-e1rHmjIeYq1JVUENJ0yYrc4QcgDOmFCg6H6NSCRSBao20QsiwBmBFriBVTSOrbEluT7ajs1979EH0xmvsOjmg3XvBirKsy5IX9URNT1TtrPcOGzE600t3EIyKOSHRijkhMSd0xLJZ9HASTU_jt0EnvDY4aATjUAcB1vwn_wWYLHOd</recordid><startdate>20150415</startdate><enddate>20150415</enddate><creator>Tóth, Ildikó Y.</creator><creator>Veress, Gábor</creator><creator>Szekeres, Márta</creator><creator>Illés, Erzsébet</creator><creator>Tombácz, Etelka</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20150415</creationdate><title>Magnetic hyaluronate hydrogels: preparation and characterization</title><author>Tóth, Ildikó Y. ; Veress, Gábor ; Szekeres, Márta ; Illés, Erzsébet ; Tombácz, Etelka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-4b7b8d9d702f375ed5dd411bbdb00001b2ad0ed0cce08ed3e9dd165bd2bffa83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Agglomeration</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Chondroitin-sulfate-A</topic><topic>Coprecipitation</topic><topic>Hyaluronate</topic><topic>Hydrogels</topic><topic>Intra-articular injection</topic><topic>Loads (forces)</topic><topic>Magnetic hydrogels</topic><topic>Magnetism</topic><topic>Magnetite</topic><topic>Rheological properties</topic><topic>Surface modification</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tóth, Ildikó Y.</creatorcontrib><creatorcontrib>Veress, Gábor</creatorcontrib><creatorcontrib>Szekeres, Márta</creatorcontrib><creatorcontrib>Illés, Erzsébet</creatorcontrib><creatorcontrib>Tombácz, Etelka</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of magnetism and magnetic materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tóth, Ildikó Y.</au><au>Veress, Gábor</au><au>Szekeres, Márta</au><au>Illés, Erzsébet</au><au>Tombácz, Etelka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic hyaluronate hydrogels: preparation and characterization</atitle><jtitle>Journal of magnetism and magnetic materials</jtitle><date>2015-04-15</date><risdate>2015</risdate><volume>380</volume><spage>175</spage><epage>180</epage><pages>175-180</pages><issn>0304-8853</issn><abstract>A novel soft way of hyaluronate (HyA) based magnetic hydrogel preparation was revealed. Magnetite nanoparticles (MNPs) were prepared by co-precipitation. Since the naked MNPs cannot be dispersed homogenously in HyA-gel, their surface was modified with natural and biocompatible chondroitin-sulfate-A (CSA) to obtain CSA-coated MNPs (CSA@MNPs). The aggregation state of MNPs and that loaded with increasing amount of CSA up to 1mmol/g was measured by dynamic light scattering at pH~6. Only CSA@MNP with ≥0.2mmol/g CSA content was suitable for magnetic HyA-gel preparation. Rheological studies showed that the presence of CSA@MNP with up to 2g/L did not affect the hydrogel's rheological behavior significantly. The results suggest that the HyA-based magnetic hydrogels may be promising formulations for future biomedical applications, e.g. as intra-articular injections in the treatment of osteoarthritis.
•Novel hyaluronate(HyA)-based biocompatible magnetic hydrogels were prepared.•Chondroitin-sulfate-A coating is needed to disperse magnetite particles in HyA-gel.•Rheological behavior of hydrogels was independent of the magnetite content (<2g/L).•Gels remained in stable and homogeneously dispersed state even after 90 days storage.•Magnetic HyA-gels are promising candidates for use as intra-articular injection.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.jmmm.2014.10.139</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | Agglomeration Biocompatibility Biomedical materials Chondroitin-sulfate-A Coprecipitation Hyaluronate Hydrogels Intra-articular injection Loads (forces) Magnetic hydrogels Magnetism Magnetite Rheological properties Surface modification |
| title | Magnetic hyaluronate hydrogels: preparation and characterization |
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