Exposure to polycyclic aromatic hydrocarbons could cause their oxidative DNA damage: a case study for college students in Guangzhou, China
Human exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) in cigarette smoking might result in generation of reactive oxygen species (ROS) and induce formation of 8-hydroxy-2′-deoxyguanosine (8-OHdG). This study was designed to examine whether levels of 8-OHdG are associated with levels...
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| creator | Li, Junnan Fan, Ruifang Lu, Shaoyou Zhang, Dongru Zhou, Yuanxiu Lv, Yanshan |
| description | Human exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) in cigarette smoking might result in generation of reactive oxygen species (ROS) and induce formation of 8-hydroxy-2′-deoxyguanosine (8-OHdG). This study was designed to examine whether levels of 8-OHdG are associated with levels of urinary metabolites of PAHs. Two groups (smokers and non-smokers) were recruited from college students in Guangzhou, China. Their urine samples were collected and analyzed for ten urinary mono-hydroxylated PAHs (OH-PAHs) and 8-OHdG by liquid chromatography equipped with tandem mass spectrometer (LC/MS/MS). Multiple linear regression analysis was performed to examine correlations between urinary levels of 8-OHdG and OH-PAHs. No significant difference was observed for creatinine-adjusted OH-PAHs between smokers and non-smokers. The levels of 8-OHdG between smokers and non-smokers were comparative. OH-PAH levels in this study were 2–50 times higher than those in populations from other countries and areas. The estimated daily intake (EDI; μg/day) of PAHs ranged from 0.02 to 371.4, which were far lower than the reference doses (RfDs) specified by U.S. Environmental Protection Agency (EPA). Though smoking was a main factor, which affected the PAH exposure, it was not a dominant factor in the exposure to PAHs of Guangzhou college students. The environmental exposure could not be ignored. The sum concentrations of OH-PAHs (∑OH-PAHs) had a dose-increase relationship with 8-OHdG both for smokers and non-smokers, especially for smokers. Though people in Guangzhou bore higher PAH hazards, the estimated environmental risk was still under safe ranges. |
| doi_str_mv | 10.1007/s11356-014-2769-z |
| format | Article |
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This study was designed to examine whether levels of 8-OHdG are associated with levels of urinary metabolites of PAHs. Two groups (smokers and non-smokers) were recruited from college students in Guangzhou, China. Their urine samples were collected and analyzed for ten urinary mono-hydroxylated PAHs (OH-PAHs) and 8-OHdG by liquid chromatography equipped with tandem mass spectrometer (LC/MS/MS). Multiple linear regression analysis was performed to examine correlations between urinary levels of 8-OHdG and OH-PAHs. No significant difference was observed for creatinine-adjusted OH-PAHs between smokers and non-smokers. The levels of 8-OHdG between smokers and non-smokers were comparative. OH-PAH levels in this study were 2–50 times higher than those in populations from other countries and areas. The estimated daily intake (EDI; μg/day) of PAHs ranged from 0.02 to 371.4, which were far lower than the reference doses (RfDs) specified by U.S. Environmental Protection Agency (EPA). Though smoking was a main factor, which affected the PAH exposure, it was not a dominant factor in the exposure to PAHs of Guangzhou college students. The environmental exposure could not be ignored. The sum concentrations of OH-PAHs (∑OH-PAHs) had a dose-increase relationship with 8-OHdG both for smokers and non-smokers, especially for smokers. Though people in Guangzhou bore higher PAH hazards, the estimated environmental risk was still under safe ranges.</description><identifier>ISSN: 0944-1344</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-014-2769-z</identifier><identifier>PMID: 24691933</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Air pollution ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; average daily intake ; Biomarkers ; Biomarkers - urine ; carcinogenicity ; Carcinogens ; Case studies ; China ; Chromatography ; Chromatography, Liquid ; Cigarettes ; College students ; Colleges ; Contaminants ; Creatinine ; Deoxyguanosine - analogs & derivatives ; Deoxyguanosine - urine ; Developments and Applications of Environmental Specimen Banks for Monitoring Emerging Contaminants ; DNA Damage ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; environmental exposure ; Environmental Exposure - analysis ; Environmental Health ; Environmental Pollutants - urine ; Environmental protection ; Environmental risk ; Exposure ; Female ; Human exposure ; Humans ; linear models ; Liquid chromatography ; Male ; Metabolites ; Pollution monitoring ; Polyallylamine hydrochloride ; Polycyclic aromatic hydrocarbons ; Polycyclic Aromatic Hydrocarbons - urine ; reactive oxygen species ; Regression analysis ; risk ; Smoking ; smoking (habit) ; Smoking - urine ; Students ; Studies ; Tandem Mass Spectrometry ; Urine ; Waste Water Technology ; Water Management ; Water Pollution Control ; Young Adult</subject><ispartof>Environmental science and pollution research international, 2015-02, Vol.22 (3), p.1770-1777</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c573t-977cf775c7450250d144a6c0bed4bf598d803eb7121a3c729b7273add92bffd63</citedby><cites>FETCH-LOGICAL-c573t-977cf775c7450250d144a6c0bed4bf598d803eb7121a3c729b7273add92bffd63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-014-2769-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-014-2769-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24691933$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Junnan</creatorcontrib><creatorcontrib>Fan, Ruifang</creatorcontrib><creatorcontrib>Lu, Shaoyou</creatorcontrib><creatorcontrib>Zhang, Dongru</creatorcontrib><creatorcontrib>Zhou, Yuanxiu</creatorcontrib><creatorcontrib>Lv, Yanshan</creatorcontrib><title>Exposure to polycyclic aromatic hydrocarbons could cause their oxidative DNA damage: a case study for college students in Guangzhou, China</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Human exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) in cigarette smoking might result in generation of reactive oxygen species (ROS) and induce formation of 8-hydroxy-2′-deoxyguanosine (8-OHdG). This study was designed to examine whether levels of 8-OHdG are associated with levels of urinary metabolites of PAHs. Two groups (smokers and non-smokers) were recruited from college students in Guangzhou, China. Their urine samples were collected and analyzed for ten urinary mono-hydroxylated PAHs (OH-PAHs) and 8-OHdG by liquid chromatography equipped with tandem mass spectrometer (LC/MS/MS). Multiple linear regression analysis was performed to examine correlations between urinary levels of 8-OHdG and OH-PAHs. No significant difference was observed for creatinine-adjusted OH-PAHs between smokers and non-smokers. The levels of 8-OHdG between smokers and non-smokers were comparative. OH-PAH levels in this study were 2–50 times higher than those in populations from other countries and areas. The estimated daily intake (EDI; μg/day) of PAHs ranged from 0.02 to 371.4, which were far lower than the reference doses (RfDs) specified by U.S. Environmental Protection Agency (EPA). Though smoking was a main factor, which affected the PAH exposure, it was not a dominant factor in the exposure to PAHs of Guangzhou college students. The environmental exposure could not be ignored. The sum concentrations of OH-PAHs (∑OH-PAHs) had a dose-increase relationship with 8-OHdG both for smokers and non-smokers, especially for smokers. Though people in Guangzhou bore higher PAH hazards, the estimated environmental risk was still under safe ranges.</description><subject>Adult</subject><subject>Air pollution</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>average daily intake</subject><subject>Biomarkers</subject><subject>Biomarkers - urine</subject><subject>carcinogenicity</subject><subject>Carcinogens</subject><subject>Case studies</subject><subject>China</subject><subject>Chromatography</subject><subject>Chromatography, Liquid</subject><subject>Cigarettes</subject><subject>College students</subject><subject>Colleges</subject><subject>Contaminants</subject><subject>Creatinine</subject><subject>Deoxyguanosine - analogs & derivatives</subject><subject>Deoxyguanosine - urine</subject><subject>Developments and Applications of Environmental Specimen Banks for Monitoring Emerging Contaminants</subject><subject>DNA Damage</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>environmental exposure</subject><subject>Environmental Exposure - analysis</subject><subject>Environmental Health</subject><subject>Environmental Pollutants - urine</subject><subject>Environmental protection</subject><subject>Environmental risk</subject><subject>Exposure</subject><subject>Female</subject><subject>Human exposure</subject><subject>Humans</subject><subject>linear models</subject><subject>Liquid chromatography</subject><subject>Male</subject><subject>Metabolites</subject><subject>Pollution monitoring</subject><subject>Polyallylamine hydrochloride</subject><subject>Polycyclic aromatic hydrocarbons</subject><subject>Polycyclic Aromatic Hydrocarbons - urine</subject><subject>reactive oxygen species</subject><subject>Regression analysis</subject><subject>risk</subject><subject>Smoking</subject><subject>smoking (habit)</subject><subject>Smoking - urine</subject><subject>Students</subject><subject>Studies</subject><subject>Tandem Mass Spectrometry</subject><subject>Urine</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><subject>Young 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to polycyclic aromatic hydrocarbons could cause their oxidative DNA damage: a case study for college students in Guangzhou, China</title><author>Li, Junnan ; Fan, Ruifang ; Lu, Shaoyou ; Zhang, Dongru ; Zhou, Yuanxiu ; Lv, Yanshan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c573t-977cf775c7450250d144a6c0bed4bf598d803eb7121a3c729b7273add92bffd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Air pollution</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>average daily intake</topic><topic>Biomarkers</topic><topic>Biomarkers - urine</topic><topic>carcinogenicity</topic><topic>Carcinogens</topic><topic>Case studies</topic><topic>China</topic><topic>Chromatography</topic><topic>Chromatography, Liquid</topic><topic>Cigarettes</topic><topic>College 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Junnan</au><au>Fan, Ruifang</au><au>Lu, Shaoyou</au><au>Zhang, Dongru</au><au>Zhou, Yuanxiu</au><au>Lv, Yanshan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure to polycyclic aromatic hydrocarbons could cause their oxidative DNA damage: a case study for college students in Guangzhou, China</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>22</volume><issue>3</issue><spage>1770</spage><epage>1777</epage><pages>1770-1777</pages><issn>0944-1344</issn><eissn>1614-7499</eissn><abstract>Human exposure to carcinogenic polycyclic aromatic hydrocarbons (PAHs) in cigarette smoking might result in generation of reactive oxygen species (ROS) and induce formation of 8-hydroxy-2′-deoxyguanosine (8-OHdG). This study was designed to examine whether levels of 8-OHdG are associated with levels of urinary metabolites of PAHs. Two groups (smokers and non-smokers) were recruited from college students in Guangzhou, China. Their urine samples were collected and analyzed for ten urinary mono-hydroxylated PAHs (OH-PAHs) and 8-OHdG by liquid chromatography equipped with tandem mass spectrometer (LC/MS/MS). Multiple linear regression analysis was performed to examine correlations between urinary levels of 8-OHdG and OH-PAHs. No significant difference was observed for creatinine-adjusted OH-PAHs between smokers and non-smokers. The levels of 8-OHdG between smokers and non-smokers were comparative. OH-PAH levels in this study were 2–50 times higher than those in populations from other countries and areas. The estimated daily intake (EDI; μg/day) of PAHs ranged from 0.02 to 371.4, which were far lower than the reference doses (RfDs) specified by U.S. Environmental Protection Agency (EPA). Though smoking was a main factor, which affected the PAH exposure, it was not a dominant factor in the exposure to PAHs of Guangzhou college students. The environmental exposure could not be ignored. The sum concentrations of OH-PAHs (∑OH-PAHs) had a dose-increase relationship with 8-OHdG both for smokers and non-smokers, especially for smokers. Though people in Guangzhou bore higher PAH hazards, the estimated environmental risk was still under safe ranges.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>24691933</pmid><doi>10.1007/s11356-014-2769-z</doi><tpages>8</tpages></addata></record> |
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| ispartof | Environmental science and pollution research international, 2015-02, Vol.22 (3), p.1770-1777 |
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| subjects | Adult Air pollution Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution average daily intake Biomarkers Biomarkers - urine carcinogenicity Carcinogens Case studies China Chromatography Chromatography, Liquid Cigarettes College students Colleges Contaminants Creatinine Deoxyguanosine - analogs & derivatives Deoxyguanosine - urine Developments and Applications of Environmental Specimen Banks for Monitoring Emerging Contaminants DNA Damage Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry environmental exposure Environmental Exposure - analysis Environmental Health Environmental Pollutants - urine Environmental protection Environmental risk Exposure Female Human exposure Humans linear models Liquid chromatography Male Metabolites Pollution monitoring Polyallylamine hydrochloride Polycyclic aromatic hydrocarbons Polycyclic Aromatic Hydrocarbons - urine reactive oxygen species Regression analysis risk Smoking smoking (habit) Smoking - urine Students Studies Tandem Mass Spectrometry Urine Waste Water Technology Water Management Water Pollution Control Young Adult |
| title | Exposure to polycyclic aromatic hydrocarbons could cause their oxidative DNA damage: a case study for college students in Guangzhou, China |
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