In vitro cytotoxicity of Fe–Cr–Nb–B magnetic nanoparticles under high frequency electromagnetic field
The heating potential, cytotoxicity, and efficiency of Fe68.2Cr11.5Nb0.3B20 magnetic nanoparticles (MNPs), as such or coated with a chitosan layer, to decrease the cell viability in a cancer cell culture model by using high frequency alternating magnetic fields (AMF) have been studied. The specific...
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| Veröffentlicht in: | Journal of magnetism and magnetic materials 2015-04, Vol.380, p.13-19 |
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| container_title | Journal of magnetism and magnetic materials |
| container_volume | 380 |
| creator | Chiriac, Horia Petreus, Tudor Carasevici, Eugen Labusca, Luminita Herea, Dumitru-Daniel Danceanu, Camelia Lupu, Nicoleta |
| description | The heating potential, cytotoxicity, and efficiency of Fe68.2Cr11.5Nb0.3B20 magnetic nanoparticles (MNPs), as such or coated with a chitosan layer, to decrease the cell viability in a cancer cell culture model by using high frequency alternating magnetic fields (AMF) have been studied. The specific absorption rate varied from 215W/g for chitosan-free MNPs to about 190W/g for chitosan-coated ones, and an equilibrium temperature of 46°C was reached when chitosan-coated MNPs were subjected to AMF. The chitosan-free Fe68.2Cr11.5Nb0.3B20 MNPs proved a good biocompatibility and low cytotoxicity in all testing conditions, while the chitosan-coated ones induced strong tumoricidal effects when a cell–particle simultaneous co-incubation approach was used. In high frequency AMF, the particle-mediated heat treatment has proved to be a critical cause for decreasing in vitro the viability of a cancer cell line. |
| doi_str_mv | 10.1016/j.jmmm.2014.10.015 |
| format | Article |
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The specific absorption rate varied from 215W/g for chitosan-free MNPs to about 190W/g for chitosan-coated ones, and an equilibrium temperature of 46°C was reached when chitosan-coated MNPs were subjected to AMF. The chitosan-free Fe68.2Cr11.5Nb0.3B20 MNPs proved a good biocompatibility and low cytotoxicity in all testing conditions, while the chitosan-coated ones induced strong tumoricidal effects when a cell–particle simultaneous co-incubation approach was used. 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The specific absorption rate varied from 215W/g for chitosan-free MNPs to about 190W/g for chitosan-coated ones, and an equilibrium temperature of 46°C was reached when chitosan-coated MNPs were subjected to AMF. The chitosan-free Fe68.2Cr11.5Nb0.3B20 MNPs proved a good biocompatibility and low cytotoxicity in all testing conditions, while the chitosan-coated ones induced strong tumoricidal effects when a cell–particle simultaneous co-incubation approach was used. In high frequency AMF, the particle-mediated heat treatment has proved to be a critical cause for decreasing in vitro the viability of a cancer cell line.</description><subject>Biocompatibility</subject><subject>Biotechnology</subject><subject>Cancer</subject><subject>Curie temperature</subject><subject>Electromagnetic fields</subject><subject>Heat treatment</subject><subject>High frequencies</subject><subject>In vitro testing</subject><subject>Magnetic fields</subject><subject>Magnetic hyperthermia</subject><subject>Magnetic nanoparticles</subject><subject>Nanoparticles</subject><subject>Viability</subject><issn>0304-8853</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9kDtOAzEQhrcAifC4AJVLmix-7MsSDUQEIkXQQG059jjxsrsO9iZiO-7ADTkJXgVR0syMZuYfzf8lySXBKcGkuK7Tum3blGKSxUaKSX6UTDDD2bSqcnaSnIZQYxynVTFJ3hYd2tveO6SG3vXuwyrbD8gZNIfvz6-Zj-FpFcMdauW6g94q1MnObaWPZQMB7ToNHm3seoOMh_cddGpA0ICKR_8kxkKjz5NjI5sAF7_5LHmd37_MHqfL54fF7HY5VYzzfppTZYrS6LI0GVaUMsaU1mwlCeUsN5Lnqsokrki-4oRwJnOdMcYzTnNdQUbZWXJ1uLv1Lv4TetHaoKBpZAduFwQpypIXZUQQV-lhVXkXggcjtt620g-CYDHSFLUYaYqR5tiLNKPo5iCCaGJvwYugbLQN2vpoW2hn_5P_ADKGg9Y</recordid><startdate>20150415</startdate><enddate>20150415</enddate><creator>Chiriac, Horia</creator><creator>Petreus, Tudor</creator><creator>Carasevici, Eugen</creator><creator>Labusca, Luminita</creator><creator>Herea, Dumitru-Daniel</creator><creator>Danceanu, Camelia</creator><creator>Lupu, Nicoleta</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20150415</creationdate><title>In vitro cytotoxicity of Fe–Cr–Nb–B magnetic nanoparticles under high frequency electromagnetic field</title><author>Chiriac, Horia ; Petreus, Tudor ; Carasevici, Eugen ; Labusca, Luminita ; Herea, Dumitru-Daniel ; Danceanu, Camelia ; Lupu, Nicoleta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-52cf67fd77f40c22333cdd3ba12935fa95c84a0815b91193a5d43394925d8e423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biocompatibility</topic><topic>Biotechnology</topic><topic>Cancer</topic><topic>Curie temperature</topic><topic>Electromagnetic fields</topic><topic>Heat treatment</topic><topic>High frequencies</topic><topic>In vitro testing</topic><topic>Magnetic fields</topic><topic>Magnetic hyperthermia</topic><topic>Magnetic nanoparticles</topic><topic>Nanoparticles</topic><topic>Viability</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiriac, Horia</creatorcontrib><creatorcontrib>Petreus, Tudor</creatorcontrib><creatorcontrib>Carasevici, Eugen</creatorcontrib><creatorcontrib>Labusca, Luminita</creatorcontrib><creatorcontrib>Herea, Dumitru-Daniel</creatorcontrib><creatorcontrib>Danceanu, Camelia</creatorcontrib><creatorcontrib>Lupu, Nicoleta</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of magnetism and magnetic materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiriac, Horia</au><au>Petreus, Tudor</au><au>Carasevici, Eugen</au><au>Labusca, Luminita</au><au>Herea, Dumitru-Daniel</au><au>Danceanu, Camelia</au><au>Lupu, Nicoleta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vitro cytotoxicity of Fe–Cr–Nb–B magnetic nanoparticles under high frequency electromagnetic field</atitle><jtitle>Journal of magnetism and magnetic materials</jtitle><date>2015-04-15</date><risdate>2015</risdate><volume>380</volume><spage>13</spage><epage>19</epage><pages>13-19</pages><issn>0304-8853</issn><abstract>The heating potential, cytotoxicity, and efficiency of Fe68.2Cr11.5Nb0.3B20 magnetic nanoparticles (MNPs), as such or coated with a chitosan layer, to decrease the cell viability in a cancer cell culture model by using high frequency alternating magnetic fields (AMF) have been studied. 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| source | Elsevier ScienceDirect Journals |
| subjects | Biocompatibility Biotechnology Cancer Curie temperature Electromagnetic fields Heat treatment High frequencies In vitro testing Magnetic fields Magnetic hyperthermia Magnetic nanoparticles Nanoparticles Viability |
| title | In vitro cytotoxicity of Fe–Cr–Nb–B magnetic nanoparticles under high frequency electromagnetic field |
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