Bioactive-rich extracts of persimmon, but not nettle, Sideritis, dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin-1 secretion by human vascular endothelial cells
BACKGROUND There is increasing evidence that consumption of plant bioactives such as polyphenols and glucosinolates reduces cardiovascular disease risk and improves endothelial function. In the Black Sea area, a number of plants are consumed alone and as ingredients in traditional foods, and dill, n...
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| Veröffentlicht in: | Journal of the science of food and agriculture 2013-11, Vol.93 (14), p.3574-3580 |
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| container_title | Journal of the science of food and agriculture |
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| creator | Woodcock, Mark E Hollands, Wendy J Konic-Ristic, Aleksandra Glibetic, Maria Boyko, Nadiya Koçaoglu, Bike Kroon, Paul A |
| description | BACKGROUND
There is increasing evidence that consumption of plant bioactives such as polyphenols and glucosinolates reduces cardiovascular disease risk and improves endothelial function. In the Black Sea area, a number of plants are consumed alone and as ingredients in traditional foods, and dill, nettle, kale, Sideritis and persimmon were identified as bioactive‐rich traditional food plants. The present study investigated the effects of plant extracts on cellular markers of endothelial function (eNOS activation and expression and ET‐1 secretion).
RESULTS
Treatment of human umbilical vein endothelial cells with persimmon extract significantly increased Akt and eNOS phosphorylation and nitric oxide metabolites and significantly decreased secretion of ET‐1 to the media after 24 h compared with a vehicle control (all P < 0.01). None of the other plant extracts significantly altered any markers of endothelial function.
CONCLUSION
These findings suggest that persimmon fruit contains bioactives that can improve endothelial function via activation of eNOS and reduction in ET‐1 secretion, but that dill, kale, Sideritis and nettle do not. © 2013 Society of Chemical Industry |
| doi_str_mv | 10.1002/jsfa.6251 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1677966238</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1677966238</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3721-facfef3f151afbe72bbee86c4438350282a50f276dbfcf9b41c9ad44813b167d3</originalsourceid><addsrcrecordid>eNqNkt9u0zAUxiMEYt3gghdAlrgBqdn8L0lzOSa6AVM7qSAuLcc5Vt05SWc73fqCPBdO2w0JCcGFZfmc3_cd2_qS5A3BpwRjerbyWp7mNCPPkhHBZZFiTPDzZBR7NM0Ip0fJsfcrjHFZ5vnL5IiygvMJYaPk50fTSRXMBlJn1BLBQ3Dx7FGn0RqcN03TtWNU9QG1XVwQgoUxWpganAnGj1FtrEWdQ7dyaJhWOZAeEMzmC7RzlsF0LZJtjWZzVMVxG2msrIw1Ybsr1_CoaesuLMGaNiXID9WdtNqiZd_IFm2kV72V7jcoLVJgrX-VvNDSenh92E-S79NP3y6u0uv55eeL8-tUsYKSVEulQTNNMiJ1BQWtKoBJrjhnE5ZhOqEyw5oWeV1ppcuKE1XKevdVFcmLmp0k7_e-a9fd9eCDaIwfbiBb6HovIlTEL6bR7p8oz3mWD4P_A-WMU1bmWUTf_YGuut618c07KmO8KHGkPuwp5TrvHWixdqaRbisIFkNkxBAZMUQmsm8Pjn3VQP1EPmYkAmd74N5Y2P7dSXxZTM8PluleYXyAhyeFdLciL1iRiR-zS3FzRaeLRX4jvrJfqJbdBA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1443534790</pqid></control><display><type>article</type><title>Bioactive-rich extracts of persimmon, but not nettle, Sideritis, dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin-1 secretion by human vascular endothelial cells</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><creator>Woodcock, Mark E ; Hollands, Wendy J ; Konic-Ristic, Aleksandra ; Glibetic, Maria ; Boyko, Nadiya ; Koçaoglu, Bike ; Kroon, Paul A</creator><creatorcontrib>Woodcock, Mark E ; Hollands, Wendy J ; Konic-Ristic, Aleksandra ; Glibetic, Maria ; Boyko, Nadiya ; Koçaoglu, Bike ; Kroon, Paul A</creatorcontrib><description>BACKGROUND
There is increasing evidence that consumption of plant bioactives such as polyphenols and glucosinolates reduces cardiovascular disease risk and improves endothelial function. In the Black Sea area, a number of plants are consumed alone and as ingredients in traditional foods, and dill, nettle, kale, Sideritis and persimmon were identified as bioactive‐rich traditional food plants. The present study investigated the effects of plant extracts on cellular markers of endothelial function (eNOS activation and expression and ET‐1 secretion).
RESULTS
Treatment of human umbilical vein endothelial cells with persimmon extract significantly increased Akt and eNOS phosphorylation and nitric oxide metabolites and significantly decreased secretion of ET‐1 to the media after 24 h compared with a vehicle control (all P < 0.01). None of the other plant extracts significantly altered any markers of endothelial function.
CONCLUSION
These findings suggest that persimmon fruit contains bioactives that can improve endothelial function via activation of eNOS and reduction in ET‐1 secretion, but that dill, kale, Sideritis and nettle do not. © 2013 Society of Chemical Industry</description><identifier>ISSN: 0022-5142</identifier><identifier>EISSN: 1097-0010</identifier><identifier>DOI: 10.1002/jsfa.6251</identifier><identifier>PMID: 23744813</identifier><identifier>CODEN: JSFAAE</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Activation ; Anethum graveolens - chemistry ; Biocompatibility ; Biomedical materials ; Black Sea ; Brassica - chemistry ; Bulgaria ; cardiovascular disease ; Culture ; Culture Media, Conditioned - chemistry ; Diospyros - chemistry ; endothelial function ; Endothelin-1 - secretion ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - metabolism ; eNOS ; Enzyme Activation - drug effects ; Flowers & plants ; Food ; Foods ; Fruit ; Functional foods & nutraceuticals ; Georgia (Republic) ; Human Umbilical Vein Endothelial Cells ; Humans ; Metabolites ; Nitrates - analysis ; Nitric oxide ; Nitric Oxide - metabolism ; Nitric Oxide Synthase Type III - metabolism ; Nitrites - analysis ; Organic chemicals ; persimmon ; Persimmons ; Phenols - analysis ; Phosphorylation ; Plant Extracts - pharmacology ; Plants (organisms) ; Polyphenols ; Romania ; Russia ; Secretions ; Serbia ; Sideritis - chemistry ; Surgical implants ; traditional foods ; Turkey ; Ukraine ; Urtica dioica - chemistry</subject><ispartof>Journal of the science of food and agriculture, 2013-11, Vol.93 (14), p.3574-3580</ispartof><rights>2013 Society of Chemical Industry</rights><rights>2013 Society of Chemical Industry.</rights><rights>Copyright John Wiley and Sons, Limited Nov 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3721-facfef3f151afbe72bbee86c4438350282a50f276dbfcf9b41c9ad44813b167d3</citedby><cites>FETCH-LOGICAL-c3721-facfef3f151afbe72bbee86c4438350282a50f276dbfcf9b41c9ad44813b167d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjsfa.6251$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjsfa.6251$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23744813$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Woodcock, Mark E</creatorcontrib><creatorcontrib>Hollands, Wendy J</creatorcontrib><creatorcontrib>Konic-Ristic, Aleksandra</creatorcontrib><creatorcontrib>Glibetic, Maria</creatorcontrib><creatorcontrib>Boyko, Nadiya</creatorcontrib><creatorcontrib>Koçaoglu, Bike</creatorcontrib><creatorcontrib>Kroon, Paul A</creatorcontrib><title>Bioactive-rich extracts of persimmon, but not nettle, Sideritis, dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin-1 secretion by human vascular endothelial cells</title><title>Journal of the science of food and agriculture</title><addtitle>J. Sci. Food Agric</addtitle><description>BACKGROUND
There is increasing evidence that consumption of plant bioactives such as polyphenols and glucosinolates reduces cardiovascular disease risk and improves endothelial function. In the Black Sea area, a number of plants are consumed alone and as ingredients in traditional foods, and dill, nettle, kale, Sideritis and persimmon were identified as bioactive‐rich traditional food plants. The present study investigated the effects of plant extracts on cellular markers of endothelial function (eNOS activation and expression and ET‐1 secretion).
RESULTS
Treatment of human umbilical vein endothelial cells with persimmon extract significantly increased Akt and eNOS phosphorylation and nitric oxide metabolites and significantly decreased secretion of ET‐1 to the media after 24 h compared with a vehicle control (all P < 0.01). None of the other plant extracts significantly altered any markers of endothelial function.
CONCLUSION
These findings suggest that persimmon fruit contains bioactives that can improve endothelial function via activation of eNOS and reduction in ET‐1 secretion, but that dill, kale, Sideritis and nettle do not. © 2013 Society of Chemical Industry</description><subject>Activation</subject><subject>Anethum graveolens - chemistry</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Black Sea</subject><subject>Brassica - chemistry</subject><subject>Bulgaria</subject><subject>cardiovascular disease</subject><subject>Culture</subject><subject>Culture Media, Conditioned - chemistry</subject><subject>Diospyros - chemistry</subject><subject>endothelial function</subject><subject>Endothelin-1 - secretion</subject><subject>Endothelium, Vascular - drug effects</subject><subject>Endothelium, Vascular - metabolism</subject><subject>eNOS</subject><subject>Enzyme Activation - drug effects</subject><subject>Flowers & plants</subject><subject>Food</subject><subject>Foods</subject><subject>Fruit</subject><subject>Functional foods & nutraceuticals</subject><subject>Georgia (Republic)</subject><subject>Human Umbilical Vein Endothelial Cells</subject><subject>Humans</subject><subject>Metabolites</subject><subject>Nitrates - analysis</subject><subject>Nitric oxide</subject><subject>Nitric Oxide - metabolism</subject><subject>Nitric Oxide Synthase Type III - metabolism</subject><subject>Nitrites - analysis</subject><subject>Organic chemicals</subject><subject>persimmon</subject><subject>Persimmons</subject><subject>Phenols - analysis</subject><subject>Phosphorylation</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants (organisms)</subject><subject>Polyphenols</subject><subject>Romania</subject><subject>Russia</subject><subject>Secretions</subject><subject>Serbia</subject><subject>Sideritis - chemistry</subject><subject>Surgical implants</subject><subject>traditional foods</subject><subject>Turkey</subject><subject>Ukraine</subject><subject>Urtica dioica - chemistry</subject><issn>0022-5142</issn><issn>1097-0010</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkt9u0zAUxiMEYt3gghdAlrgBqdn8L0lzOSa6AVM7qSAuLcc5Vt05SWc73fqCPBdO2w0JCcGFZfmc3_cd2_qS5A3BpwRjerbyWp7mNCPPkhHBZZFiTPDzZBR7NM0Ip0fJsfcrjHFZ5vnL5IiygvMJYaPk50fTSRXMBlJn1BLBQ3Dx7FGn0RqcN03TtWNU9QG1XVwQgoUxWpganAnGj1FtrEWdQ7dyaJhWOZAeEMzmC7RzlsF0LZJtjWZzVMVxG2msrIw1Ybsr1_CoaesuLMGaNiXID9WdtNqiZd_IFm2kV72V7jcoLVJgrX-VvNDSenh92E-S79NP3y6u0uv55eeL8-tUsYKSVEulQTNNMiJ1BQWtKoBJrjhnE5ZhOqEyw5oWeV1ppcuKE1XKevdVFcmLmp0k7_e-a9fd9eCDaIwfbiBb6HovIlTEL6bR7p8oz3mWD4P_A-WMU1bmWUTf_YGuut618c07KmO8KHGkPuwp5TrvHWixdqaRbisIFkNkxBAZMUQmsm8Pjn3VQP1EPmYkAmd74N5Y2P7dSXxZTM8PluleYXyAhyeFdLciL1iRiR-zS3FzRaeLRX4jvrJfqJbdBA</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Woodcock, Mark E</creator><creator>Hollands, Wendy J</creator><creator>Konic-Ristic, Aleksandra</creator><creator>Glibetic, Maria</creator><creator>Boyko, Nadiya</creator><creator>Koçaoglu, Bike</creator><creator>Kroon, Paul A</creator><general>John Wiley & Sons, Ltd</general><general>John Wiley and Sons, Limited</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QL</scope><scope>7QQ</scope><scope>7QR</scope><scope>7SC</scope><scope>7SE</scope><scope>7SN</scope><scope>7SP</scope><scope>7SR</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7TM</scope><scope>7U5</scope><scope>7U9</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>H94</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>M7N</scope><scope>P64</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>201311</creationdate><title>Bioactive-rich extracts of persimmon, but not nettle, Sideritis, dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin-1 secretion by human vascular endothelial cells</title><author>Woodcock, Mark E ; Hollands, Wendy J ; Konic-Ristic, Aleksandra ; Glibetic, Maria ; Boyko, Nadiya ; Koçaoglu, Bike ; Kroon, Paul A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3721-facfef3f151afbe72bbee86c4438350282a50f276dbfcf9b41c9ad44813b167d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Activation</topic><topic>Anethum graveolens - chemistry</topic><topic>Biocompatibility</topic><topic>Biomedical materials</topic><topic>Black Sea</topic><topic>Brassica - chemistry</topic><topic>Bulgaria</topic><topic>cardiovascular disease</topic><topic>Culture</topic><topic>Culture Media, Conditioned - chemistry</topic><topic>Diospyros - chemistry</topic><topic>endothelial function</topic><topic>Endothelin-1 - secretion</topic><topic>Endothelium, Vascular - drug effects</topic><topic>Endothelium, Vascular - metabolism</topic><topic>eNOS</topic><topic>Enzyme Activation - drug effects</topic><topic>Flowers & plants</topic><topic>Food</topic><topic>Foods</topic><topic>Fruit</topic><topic>Functional foods & nutraceuticals</topic><topic>Georgia (Republic)</topic><topic>Human Umbilical Vein Endothelial Cells</topic><topic>Humans</topic><topic>Metabolites</topic><topic>Nitrates - analysis</topic><topic>Nitric oxide</topic><topic>Nitric Oxide - metabolism</topic><topic>Nitric Oxide Synthase Type III - metabolism</topic><topic>Nitrites - analysis</topic><topic>Organic chemicals</topic><topic>persimmon</topic><topic>Persimmons</topic><topic>Phenols - analysis</topic><topic>Phosphorylation</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants (organisms)</topic><topic>Polyphenols</topic><topic>Romania</topic><topic>Russia</topic><topic>Secretions</topic><topic>Serbia</topic><topic>Sideritis - chemistry</topic><topic>Surgical implants</topic><topic>traditional foods</topic><topic>Turkey</topic><topic>Ukraine</topic><topic>Urtica dioica - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Woodcock, Mark E</creatorcontrib><creatorcontrib>Hollands, Wendy J</creatorcontrib><creatorcontrib>Konic-Ristic, Aleksandra</creatorcontrib><creatorcontrib>Glibetic, Maria</creatorcontrib><creatorcontrib>Boyko, Nadiya</creatorcontrib><creatorcontrib>Koçaoglu, Bike</creatorcontrib><creatorcontrib>Kroon, Paul A</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Ceramic Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Ecology Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the science of food and agriculture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Woodcock, Mark E</au><au>Hollands, Wendy J</au><au>Konic-Ristic, Aleksandra</au><au>Glibetic, Maria</au><au>Boyko, Nadiya</au><au>Koçaoglu, Bike</au><au>Kroon, Paul A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bioactive-rich extracts of persimmon, but not nettle, Sideritis, dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin-1 secretion by human vascular endothelial cells</atitle><jtitle>Journal of the science of food and agriculture</jtitle><addtitle>J. Sci. Food Agric</addtitle><date>2013-11</date><risdate>2013</risdate><volume>93</volume><issue>14</issue><spage>3574</spage><epage>3580</epage><pages>3574-3580</pages><issn>0022-5142</issn><eissn>1097-0010</eissn><coden>JSFAAE</coden><abstract>BACKGROUND
There is increasing evidence that consumption of plant bioactives such as polyphenols and glucosinolates reduces cardiovascular disease risk and improves endothelial function. In the Black Sea area, a number of plants are consumed alone and as ingredients in traditional foods, and dill, nettle, kale, Sideritis and persimmon were identified as bioactive‐rich traditional food plants. The present study investigated the effects of plant extracts on cellular markers of endothelial function (eNOS activation and expression and ET‐1 secretion).
RESULTS
Treatment of human umbilical vein endothelial cells with persimmon extract significantly increased Akt and eNOS phosphorylation and nitric oxide metabolites and significantly decreased secretion of ET‐1 to the media after 24 h compared with a vehicle control (all P < 0.01). None of the other plant extracts significantly altered any markers of endothelial function.
CONCLUSION
These findings suggest that persimmon fruit contains bioactives that can improve endothelial function via activation of eNOS and reduction in ET‐1 secretion, but that dill, kale, Sideritis and nettle do not. © 2013 Society of Chemical Industry</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>23744813</pmid><doi>10.1002/jsfa.6251</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Journal of the science of food and agriculture, 2013-11, Vol.93 (14), p.3574-3580 |
| issn | 0022-5142 1097-0010 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE |
| subjects | Activation Anethum graveolens - chemistry Biocompatibility Biomedical materials Black Sea Brassica - chemistry Bulgaria cardiovascular disease Culture Culture Media, Conditioned - chemistry Diospyros - chemistry endothelial function Endothelin-1 - secretion Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism eNOS Enzyme Activation - drug effects Flowers & plants Food Foods Fruit Functional foods & nutraceuticals Georgia (Republic) Human Umbilical Vein Endothelial Cells Humans Metabolites Nitrates - analysis Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase Type III - metabolism Nitrites - analysis Organic chemicals persimmon Persimmons Phenols - analysis Phosphorylation Plant Extracts - pharmacology Plants (organisms) Polyphenols Romania Russia Secretions Serbia Sideritis - chemistry Surgical implants traditional foods Turkey Ukraine Urtica dioica - chemistry |
| title | Bioactive-rich extracts of persimmon, but not nettle, Sideritis, dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin-1 secretion by human vascular endothelial cells |
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