Alginate/BSA/montmorillonite composites with enhanced protein entrapment and controlled release efficiency
Novel pH sensitive alginate–protein–clay composite beads were investigated for the in vitro oral delivery of the model protein, bovine serum albumin (BSA). X-ray diffraction (XRD) results revealed that BSA enter between layers of montmorillonite (MMT) by expanding interlayer distance and finally an...
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| Veröffentlicht in: | Reactive & functional polymers 2013-11, Vol.73 (11), p.1420-1425 |
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| creator | Kaygusuz, Hakan Erim, F.B. |
| description | Novel pH sensitive alginate–protein–clay composite beads were investigated for the in vitro oral delivery of the model protein, bovine serum albumin (BSA). X-ray diffraction (XRD) results revealed that BSA enter between layers of montmorillonite (MMT) by expanding interlayer distance and finally an exfoliated structure forms in the alginate hydrogel. MMT incorporation increases protein entrapment efficiency to 78%, compared to 40% of conventional alginate beads. The release ratio of BSA from composite beads is 9–13% depending on MMT contents after around a 2h stay in gastric fluid. More importantly, no BSA release is detected until 60–90min after the first contact time of beads with gastric solution. The presence of clay in alginate beads prevents burst release in higher pH of intestine by slowing release rate of BSA to 45–55% within around 9h, resulting in a potential matrix for intestinal release of protein drugs. |
| doi_str_mv | 10.1016/j.reactfunctpolym.2013.07.014 |
| format | Article |
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X-ray diffraction (XRD) results revealed that BSA enter between layers of montmorillonite (MMT) by expanding interlayer distance and finally an exfoliated structure forms in the alginate hydrogel. MMT incorporation increases protein entrapment efficiency to 78%, compared to 40% of conventional alginate beads. The release ratio of BSA from composite beads is 9–13% depending on MMT contents after around a 2h stay in gastric fluid. More importantly, no BSA release is detected until 60–90min after the first contact time of beads with gastric solution. The presence of clay in alginate beads prevents burst release in higher pH of intestine by slowing release rate of BSA to 45–55% within around 9h, resulting in a potential matrix for intestinal release of protein drugs.</description><identifier>ISSN: 1381-5148</identifier><identifier>DOI: 10.1016/j.reactfunctpolym.2013.07.014</identifier><language>eng</language><publisher>Kidlington: Elsevier B.V</publisher><subject>Alginate ; Alginates ; Applied sciences ; Beads ; Biological and medical sciences ; BSA ; Composites ; Controlled release ; Drugs ; Entrapment ; Exact sciences and technology ; Forms of application and semi-finished materials ; General pharmacology ; Intercalation ; Medical sciences ; Montmorillonite ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. 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X-ray diffraction (XRD) results revealed that BSA enter between layers of montmorillonite (MMT) by expanding interlayer distance and finally an exfoliated structure forms in the alginate hydrogel. MMT incorporation increases protein entrapment efficiency to 78%, compared to 40% of conventional alginate beads. The release ratio of BSA from composite beads is 9–13% depending on MMT contents after around a 2h stay in gastric fluid. More importantly, no BSA release is detected until 60–90min after the first contact time of beads with gastric solution. The presence of clay in alginate beads prevents burst release in higher pH of intestine by slowing release rate of BSA to 45–55% within around 9h, resulting in a potential matrix for intestinal release of protein drugs.</description><subject>Alginate</subject><subject>Alginates</subject><subject>Applied sciences</subject><subject>Beads</subject><subject>Biological and medical sciences</subject><subject>BSA</subject><subject>Composites</subject><subject>Controlled release</subject><subject>Drugs</subject><subject>Entrapment</subject><subject>Exact sciences and technology</subject><subject>Forms of application and semi-finished materials</subject><subject>General pharmacology</subject><subject>Intercalation</subject><subject>Medical sciences</subject><subject>Montmorillonite</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Polymer industry, paints, wood</subject><subject>Protein delivery</subject><subject>Proteins</subject><subject>Technology of polymers</subject><issn>1381-5148</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqNkU1vEzEQhvcAEiXlP-ylEpdsPF5_5cAhVFCQKvUAnC3HO6aOvPZiO6D8e1xSceBCTmNbj-cdzdN1N0AGICA2hyGjsdUdo61LCqd5oATGgciBAHvRXcGoYM2BqVfd61IOhIAEIa66wy5899FU3Lz_stvMKdY5ZR9Cir5ib9O8pNJOpf_l62OP8dFEi1O_5FTRx_ZQs1nmVnoTp8a3ewqhERkDmoI9Ouetx2hP191LZ0LBN8911X37-OHr7af1_cPd59vd_drykdY1lVJIPilitopsOcVJABVq2gtpCJ_ESB1MI6diT50wDKiSbgsKYO-Yk2ocV93bc9825I8jlqpnXyyGYCKmY9EgpGx9lZQXoG1lnIyM_x_lDBjZbvklKIxMMCCkoe_OqM2plIxOL9nPJp80EP0kVh_0P2L1k1hNpG5i2_-b5yhTrAkuNz2-_G1CpWKMt7hVd3fmsC3-p8esyx8pOPmMtuop-QsTfwP3FsUU</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Kaygusuz, Hakan</creator><creator>Erim, F.B.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>JG9</scope></search><sort><creationdate>20131101</creationdate><title>Alginate/BSA/montmorillonite composites with enhanced protein entrapment and controlled release efficiency</title><author>Kaygusuz, Hakan ; Erim, F.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532t-277675d80a980952ed61268db67a05d632f1d3526b2f6a41287f91811bf4f7833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Alginate</topic><topic>Alginates</topic><topic>Applied sciences</topic><topic>Beads</topic><topic>Biological and medical sciences</topic><topic>BSA</topic><topic>Composites</topic><topic>Controlled release</topic><topic>Drugs</topic><topic>Entrapment</topic><topic>Exact sciences and technology</topic><topic>Forms of application and semi-finished materials</topic><topic>General pharmacology</topic><topic>Intercalation</topic><topic>Medical sciences</topic><topic>Montmorillonite</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Polymer industry, paints, wood</topic><topic>Protein delivery</topic><topic>Proteins</topic><topic>Technology of polymers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kaygusuz, Hakan</creatorcontrib><creatorcontrib>Erim, F.B.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Research Database</collection><jtitle>Reactive & functional polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kaygusuz, Hakan</au><au>Erim, F.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alginate/BSA/montmorillonite composites with enhanced protein entrapment and controlled release efficiency</atitle><jtitle>Reactive & functional polymers</jtitle><date>2013-11-01</date><risdate>2013</risdate><volume>73</volume><issue>11</issue><spage>1420</spage><epage>1425</epage><pages>1420-1425</pages><issn>1381-5148</issn><abstract>Novel pH sensitive alginate–protein–clay composite beads were investigated for the in vitro oral delivery of the model protein, bovine serum albumin (BSA). X-ray diffraction (XRD) results revealed that BSA enter between layers of montmorillonite (MMT) by expanding interlayer distance and finally an exfoliated structure forms in the alginate hydrogel. MMT incorporation increases protein entrapment efficiency to 78%, compared to 40% of conventional alginate beads. The release ratio of BSA from composite beads is 9–13% depending on MMT contents after around a 2h stay in gastric fluid. More importantly, no BSA release is detected until 60–90min after the first contact time of beads with gastric solution. The presence of clay in alginate beads prevents burst release in higher pH of intestine by slowing release rate of BSA to 45–55% within around 9h, resulting in a potential matrix for intestinal release of protein drugs.</abstract><cop>Kidlington</cop><pub>Elsevier B.V</pub><doi>10.1016/j.reactfunctpolym.2013.07.014</doi><tpages>6</tpages></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | Alginate Alginates Applied sciences Beads Biological and medical sciences BSA Composites Controlled release Drugs Entrapment Exact sciences and technology Forms of application and semi-finished materials General pharmacology Intercalation Medical sciences Montmorillonite Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymer industry, paints, wood Protein delivery Proteins Technology of polymers |
| title | Alginate/BSA/montmorillonite composites with enhanced protein entrapment and controlled release efficiency |
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