Two novel hydroperoxylated products of 20(S)-protopanaxadiol produced by Mucor racemosus and their cytotoxic activities against human prostate cancer cells

Microbial transformation of 20(S)-protopanaxadiol (1) by Mucor racemosus AS 3.205 yielded two novel hydroperoxylated metabolites and three known hydroxylated metabolites. The structures of the metabolites were identified as 26-hydroxyl-20(S)-protopanaxadiol (2), 23,24-en-25-hydroxyl-20(S)-protopanax...

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Veröffentlicht in:	Biotechnology letters 2013-03, Vol.35 (3), p.439-443
Hauptverfasser:	Chen, Guangtong, Yang, Xue, Nong, Shaojun, Yang, Min, Xu, Bohui, Zhang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Apoptosis Applied Microbiology Biochemistry Biomedical and Life Sciences Biotechnology Biotransformation Cancer Cell Line, Tumor cytotoxicity Fungi Human Humans Life Sciences Magnetic Resonance Spectroscopy Male Metabolites Microbiology Microorganisms Molecular Structure Mucor - metabolism Mucor racemosus Original Research Paper Prostate Prostate cancer Prostatic Neoplasms Sapogenins - chemistry Sapogenins - isolation & purification Sapogenins - pharmacology Transformations
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