Graphene oxide complex as a pH-sensitive antitumor drug
A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The res...
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| Veröffentlicht in: | Polymer chemistry 2015-01, Vol.6 (13), p.2401-2406 |
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| container_title | Polymer chemistry |
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| creator | Cheng, Rumei Zou, Ruitao Ou, Shengju Guo, Rui Yan, Ruiying Shi, Haiyan Yu, Shanshan Li, Xiaojian Bu, Yexu Lin, Mimi Liu, Yong Dai, Liming |
| description | A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The resulting GCS showed superb antitumor activity with the pH-sensitive release of the antitumor part, CS, and decreased cytotoxicity of GCS to normal human cells. The release of CS was stable and thorough in the solution at pH 1 (the pH value for gastric juice), suggesting that the as-synthesized, pH-sensitive drug could provide new insights into the design of advanced nanostructured oral drugs. |
| doi_str_mv | 10.1039/C5PY00047E |
| format | Article |
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The successful synthesis of GCS was confirmed using various spectroscopic techniques, including FT-IR, XPS, UV-vis and TGA. The resulting GCS showed superb antitumor activity with the pH-sensitive release of the antitumor part, CS, and decreased cytotoxicity of GCS to normal human cells. 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The release of CS was stable and thorough in the solution at pH 1 (the pH value for gastric juice), suggesting that the as-synthesized, pH-sensitive drug could provide new insights into the design of advanced nanostructured oral drugs.</description><subject>Drugs</subject><subject>Graphene</subject><subject>Human</subject><subject>Nanostructure</subject><subject>Oxides</subject><subject>Schiff bases</subject><subject>X-ray photoelectron spectroscopy</subject><issn>1759-9954</issn><issn>1759-9962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNpFkM1KxDAYRYMoOIyz8QmyFKH6pflrllLGGWFAF7pwVULzRSP9M2llfHs7jOjq3sXhcjmEXDK4YcDNbSmfXgFA6PUJWTAtTWaMyk__uhTnZJXSx8wAZyLnakH0JtrhHTuk_T44pHXfDg3uqU3U0mGbJexSGMMXUtuNYZzaPlIXp7cLcuZtk3D1m0vycr9-LrfZ7nHzUN7tsjpXYsyEdeCtrrX0HpWWDqxnXgFKjvMHj6ZGLrzTEooChFBGgfaOqQKYc0ryJbk67g6x_5wwjVUbUo1NYzvsp1QxpbURSkk2o9dHtI59ShF9NcTQ2vhdMagOgqp_QfwHOOZXBQ</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Cheng, Rumei</creator><creator>Zou, Ruitao</creator><creator>Ou, Shengju</creator><creator>Guo, Rui</creator><creator>Yan, Ruiying</creator><creator>Shi, Haiyan</creator><creator>Yu, Shanshan</creator><creator>Li, Xiaojian</creator><creator>Bu, Yexu</creator><creator>Lin, Mimi</creator><creator>Liu, Yong</creator><creator>Dai, Liming</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8FD</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>20150101</creationdate><title>Graphene oxide complex as a pH-sensitive antitumor drug</title><author>Cheng, Rumei ; Zou, Ruitao ; Ou, Shengju ; Guo, Rui ; Yan, Ruiying ; Shi, Haiyan ; Yu, Shanshan ; Li, Xiaojian ; Bu, Yexu ; Lin, Mimi ; Liu, Yong ; Dai, Liming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c264t-4ad0fa7c75ffe675d0af1f60e53e031fe9ce34fd7508804469607fd16801dd653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Drugs</topic><topic>Graphene</topic><topic>Human</topic><topic>Nanostructure</topic><topic>Oxides</topic><topic>Schiff bases</topic><topic>X-ray photoelectron spectroscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Rumei</creatorcontrib><creatorcontrib>Zou, Ruitao</creatorcontrib><creatorcontrib>Ou, Shengju</creatorcontrib><creatorcontrib>Guo, Rui</creatorcontrib><creatorcontrib>Yan, Ruiying</creatorcontrib><creatorcontrib>Shi, Haiyan</creatorcontrib><creatorcontrib>Yu, Shanshan</creatorcontrib><creatorcontrib>Li, Xiaojian</creatorcontrib><creatorcontrib>Bu, Yexu</creatorcontrib><creatorcontrib>Lin, Mimi</creatorcontrib><creatorcontrib>Liu, Yong</creatorcontrib><creatorcontrib>Dai, Liming</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Polymer chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Rumei</au><au>Zou, Ruitao</au><au>Ou, Shengju</au><au>Guo, Rui</au><au>Yan, Ruiying</au><au>Shi, Haiyan</au><au>Yu, Shanshan</au><au>Li, Xiaojian</au><au>Bu, Yexu</au><au>Lin, Mimi</au><au>Liu, Yong</au><au>Dai, Liming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Graphene oxide complex as a pH-sensitive antitumor drug</atitle><jtitle>Polymer chemistry</jtitle><date>2015-01-01</date><risdate>2015</risdate><volume>6</volume><issue>13</issue><spage>2401</spage><epage>2406</epage><pages>2401-2406</pages><issn>1759-9954</issn><eissn>1759-9962</eissn><abstract>A pH-sensitive, nanostructured antitumor drug, GO-CONH-Schiff base (GCS), was prepared from the chitosan-xanthone Schiff base (CS)-modified graphene oxide (GO) complex. 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| ispartof | Polymer chemistry, 2015-01, Vol.6 (13), p.2401-2406 |
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| language | eng |
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| source | Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Drugs Graphene Human Nanostructure Oxides Schiff bases X-ray photoelectron spectroscopy |
| title | Graphene oxide complex as a pH-sensitive antitumor drug |
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