Preparation and characterization of ampicillin-incorporated electrospun polyurethane scaffolds for wound healing and infection control
Electrospinning is a desired method to produce interconnected flexible nanofibrous structures suitable for tissue engineering, drug delivery, and wound healing. Ampicillin‐loaded polyurethane (PU) nanofiber mats were electrospun with the antibiotic dispersed in well‐oriented nanofibers. The identifi...
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| Veröffentlicht in: | Polymer engineering and science 2015-03, Vol.55 (3), p.541-548 |
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| creator | Sabitha, M. Rajiv, Sheeja |
| description | Electrospinning is a desired method to produce interconnected flexible nanofibrous structures suitable for tissue engineering, drug delivery, and wound healing. Ampicillin‐loaded polyurethane (PU) nanofiber mats were electrospun with the antibiotic dispersed in well‐oriented nanofibers. The identification of functional groups, molecular interactions and surface morphology of the fibers were analyzed using Infrared, Raman, 1H NMR, SEM, and TEM. Weak interactions exist between the functional groups of ampicillin and PU in electrospun fibers at ratios 1:10, 1.5:10, and 2:10. The effect of β‐lactam antibiotic ampicillin on the characteristics of electrospun PU was studied using XRD, TGA, and DSC. Their antibacterial property is proved by good zone of inhibition against Staphylococcus aureus and Klebsiella pneumonia. Cytotoxicity tests on the electrospun scaffolds were performed with normal human keratinocyte cells (HaCaT cells). Results indicate that ampicillin‐incorporated PU scaffolds are well suited for applications in wound healing and infection control. POLYM. ENG. SCI., 55:541–548, 2015. © 2014 Society of Plastics Engineers |
| doi_str_mv | 10.1002/pen.23917 |
| format | Article |
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Ampicillin‐loaded polyurethane (PU) nanofiber mats were electrospun with the antibiotic dispersed in well‐oriented nanofibers. The identification of functional groups, molecular interactions and surface morphology of the fibers were analyzed using Infrared, Raman, 1H NMR, SEM, and TEM. Weak interactions exist between the functional groups of ampicillin and PU in electrospun fibers at ratios 1:10, 1.5:10, and 2:10. The effect of β‐lactam antibiotic ampicillin on the characteristics of electrospun PU was studied using XRD, TGA, and DSC. Their antibacterial property is proved by good zone of inhibition against Staphylococcus aureus and Klebsiella pneumonia. Cytotoxicity tests on the electrospun scaffolds were performed with normal human keratinocyte cells (HaCaT cells). Results indicate that ampicillin‐incorporated PU scaffolds are well suited for applications in wound healing and infection control. POLYM. ENG. 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Ampicillin‐loaded polyurethane (PU) nanofiber mats were electrospun with the antibiotic dispersed in well‐oriented nanofibers. The identification of functional groups, molecular interactions and surface morphology of the fibers were analyzed using Infrared, Raman, 1H NMR, SEM, and TEM. Weak interactions exist between the functional groups of ampicillin and PU in electrospun fibers at ratios 1:10, 1.5:10, and 2:10. The effect of β‐lactam antibiotic ampicillin on the characteristics of electrospun PU was studied using XRD, TGA, and DSC. Their antibacterial property is proved by good zone of inhibition against Staphylococcus aureus and Klebsiella pneumonia. Cytotoxicity tests on the electrospun scaffolds were performed with normal human keratinocyte cells (HaCaT cells). Results indicate that ampicillin‐incorporated PU scaffolds are well suited for applications in wound healing and infection control. POLYM. ENG. SCI., 55:541–548, 2015. © 2014 Society of Plastics Engineers</description><subject>Ampicillin</subject><subject>Antibiotics</subject><subject>Biopolymers</subject><subject>Disease control</subject><subject>Drug delivery systems</subject><subject>Electrospinning</subject><subject>Fibers</subject><subject>Functional groups</subject><subject>Infection control</subject><subject>Nanostructure</subject><subject>Polyurethane</subject><subject>Polyurethane resins</subject><subject>Polyurethanes</subject><subject>Production processes</subject><subject>Scaffolds</subject><subject>Technology application</subject><subject>Tissue engineering</subject><subject>Wound healing</subject><issn>0032-3888</issn><issn>1548-2634</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>N95</sourceid><recordid>eNp1kttu1DAQhiMEEkvhgjeIxA1IZOvYsZ1clqq0FaVUHC8trzPedcnaqZ2oLA_Q5-5stxwWLbJky6Pv_2c8nix7XpJpSQjd78FPKWtK-SCblLyqCypY9TCbEMJoweq6fpw9SemSIMt4M8luLiL0OurBBZ9r3-ZmgTczQHQ_N8Fgc73snXFd53zhvAmxDyiANocOzBBD6kef96FbjRGGhfaQJ6OtDV2bchtifh1GNF6ARoP5XRLnLSrX7iZ4dOieZo-s7hI8uz_3si9vjz4fnhRnH45PDw_OCiN4KQtdcWaBUgkNla3RvIYWZlJIPqtooythJScNJUyQGaGStVZWraCyFLamjDVsL3u58e1juBohDWrpkoGuw6rDmFQppGxYIwRH9MU_6GUYo8fqkOJNXSIp_1Bz3YHCd4UB27c2VQcV4YTSSqzTFjuoOXiIugserMPwFj_dweNqYenMTsGrLcG6rfBjmOsxJXX66eM2-_ovdjYm5yHhltx8MaSNZJe1wZ9OEazqo1vquFIlUeuZUzhz6m7mkN3fsNdY3-r_oLo4Ov-luO-MS1jwb4WO35WQTHL17fxYfX3_jnHG3qgTdguRyeZJ</recordid><startdate>201503</startdate><enddate>201503</enddate><creator>Sabitha, M.</creator><creator>Rajiv, Sheeja</creator><general>Blackwell Publishing Ltd</general><general>Society of Plastics Engineers, Inc</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>N95</scope><scope>XI7</scope><scope>ISR</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>201503</creationdate><title>Preparation and characterization of ampicillin-incorporated electrospun polyurethane scaffolds for wound healing and infection control</title><author>Sabitha, M. ; Rajiv, Sheeja</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6517-a453fe227e927dca58edeb7675b429a46f750920360b0273df74d62716f823393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Ampicillin</topic><topic>Antibiotics</topic><topic>Biopolymers</topic><topic>Disease control</topic><topic>Drug delivery systems</topic><topic>Electrospinning</topic><topic>Fibers</topic><topic>Functional groups</topic><topic>Infection control</topic><topic>Nanostructure</topic><topic>Polyurethane</topic><topic>Polyurethane resins</topic><topic>Polyurethanes</topic><topic>Production processes</topic><topic>Scaffolds</topic><topic>Technology application</topic><topic>Tissue engineering</topic><topic>Wound healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sabitha, M.</creatorcontrib><creatorcontrib>Rajiv, Sheeja</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>Gale Business: Insights</collection><collection>Business Insights: Essentials</collection><collection>Gale In Context: Science</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Polymer engineering and science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sabitha, M.</au><au>Rajiv, Sheeja</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation and characterization of ampicillin-incorporated electrospun polyurethane scaffolds for wound healing and infection control</atitle><jtitle>Polymer engineering and science</jtitle><addtitle>Polym Eng Sci</addtitle><date>2015-03</date><risdate>2015</risdate><volume>55</volume><issue>3</issue><spage>541</spage><epage>548</epage><pages>541-548</pages><issn>0032-3888</issn><eissn>1548-2634</eissn><coden>PYESAZ</coden><abstract>Electrospinning is a desired method to produce interconnected flexible nanofibrous structures suitable for tissue engineering, drug delivery, and wound healing. Ampicillin‐loaded polyurethane (PU) nanofiber mats were electrospun with the antibiotic dispersed in well‐oriented nanofibers. The identification of functional groups, molecular interactions and surface morphology of the fibers were analyzed using Infrared, Raman, 1H NMR, SEM, and TEM. Weak interactions exist between the functional groups of ampicillin and PU in electrospun fibers at ratios 1:10, 1.5:10, and 2:10. The effect of β‐lactam antibiotic ampicillin on the characteristics of electrospun PU was studied using XRD, TGA, and DSC. Their antibacterial property is proved by good zone of inhibition against Staphylococcus aureus and Klebsiella pneumonia. Cytotoxicity tests on the electrospun scaffolds were performed with normal human keratinocyte cells (HaCaT cells). Results indicate that ampicillin‐incorporated PU scaffolds are well suited for applications in wound healing and infection control. POLYM. ENG. 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| identifier | ISSN: 0032-3888 |
| ispartof | Polymer engineering and science, 2015-03, Vol.55 (3), p.541-548 |
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| language | eng |
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| source | Wiley Journals |
| subjects | Ampicillin Antibiotics Biopolymers Disease control Drug delivery systems Electrospinning Fibers Functional groups Infection control Nanostructure Polyurethane Polyurethane resins Polyurethanes Production processes Scaffolds Technology application Tissue engineering Wound healing |
| title | Preparation and characterization of ampicillin-incorporated electrospun polyurethane scaffolds for wound healing and infection control |
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