Improved neural progenitor cell proliferation and differentiation on poly(lactide-co-glycolide) scaffolds coated with elastin-like polypeptide
Poly(lactide‐co‐glycolide) (PLGA) and elastin‐like polypeptide (ELP) have been widely used as a biodegradable scaffold and thermoresponsive matrix, respectively. However, little attention has focused on the combinatorial use of these biomaterials for tissue engineering applications. An ELP matrix TG...
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| Veröffentlicht in: | Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2013-11, Vol.101 (8), p.1329-1339 |
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| container_title | Journal of biomedical materials research. Part B, Applied biomaterials |
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| creator | Choi, Seong-Kyoon Park, Jin-Kyu Lee, Kyeong-Min Lee, Soo-Keun Jeon, Won Bae |
| description | Poly(lactide‐co‐glycolide) (PLGA) and elastin‐like polypeptide (ELP) have been widely used as a biodegradable scaffold and thermoresponsive matrix, respectively. However, little attention has focused on the combinatorial use of these biomaterials for tissue engineering applications. An ELP matrix TGPG[VGRGD(VGVPG)6]20WPC (referred to as REP) contains multiple Arg‐Gly‐Asp motifs. This study fabricated porous PLGA scaffolds coated with various concentration of matrix via thermally induced phase transition to improve adhesion‐mediated proliferation and differentiation of neural progenitor cells. Matrix‐coated scaffolds were characterized by FTIR, SEM, and hematoxylin and eosin staining with respect to coating efficiency, porosity, and pore size and shape. On the matrix‐coated scaffolds, cells grew as a single cell or associated each other to form a multicellular layer or cluster. In biological evaluations, cell adhesion and proliferation were significantly promoted in a matrix concentration‐dependent manner. More importantly, in combination with retinoic acid, the differentiation of progenitor cells into neuronal and astroglial lineages was highly stimulated in the cells cultured on matrix‐coated scaffolds than on untreated controls. Taken together, our results indicated that the REP matrix‐functionalized PLGA scaffolds are suitable for improving neuronal cell functions, and thus applicable for neural tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 101B: 1329–1339, 2013. |
| doi_str_mv | 10.1002/jbm.b.32950 |
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However, little attention has focused on the combinatorial use of these biomaterials for tissue engineering applications. An ELP matrix TGPG[VGRGD(VGVPG)6]20WPC (referred to as REP) contains multiple Arg‐Gly‐Asp motifs. This study fabricated porous PLGA scaffolds coated with various concentration of matrix via thermally induced phase transition to improve adhesion‐mediated proliferation and differentiation of neural progenitor cells. Matrix‐coated scaffolds were characterized by FTIR, SEM, and hematoxylin and eosin staining with respect to coating efficiency, porosity, and pore size and shape. On the matrix‐coated scaffolds, cells grew as a single cell or associated each other to form a multicellular layer or cluster. In biological evaluations, cell adhesion and proliferation were significantly promoted in a matrix concentration‐dependent manner. More importantly, in combination with retinoic acid, the differentiation of progenitor cells into neuronal and astroglial lineages was highly stimulated in the cells cultured on matrix‐coated scaffolds than on untreated controls. Taken together, our results indicated that the REP matrix‐functionalized PLGA scaffolds are suitable for improving neuronal cell functions, and thus applicable for neural tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 101B: 1329–1339, 2013.</description><identifier>ISSN: 1552-4973</identifier><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.b.32950</identifier><identifier>PMID: 23687069</identifier><language>eng</language><publisher>Hoboken, NJ: Blackwell Publishing Ltd</publisher><subject>Amino Acid Motifs ; Aminoacid polymers ; Applied sciences ; Astrocytes - cytology ; Biological and medical sciences ; Biomarkers - metabolism ; Biomaterials ; Biomedical materials ; Biotechnology ; Cell Adhesion ; Cell Differentiation ; Cell Lineage ; Cell Proliferation ; Cells (biology) ; Coating ; Combinatorial analysis ; Differentiation ; Elastin - chemistry ; Exact sciences and technology ; extracellular matrix ; Fundamental and applied biological sciences. Psychology ; Health. Pharmaceutical industry ; Humans ; Industrial applications and implications. Economical aspects ; Materials research ; Materials science ; Medical sciences ; Miscellaneous ; Neural Stem Cells - cytology ; Peptides - chemistry ; Physicochemistry of polymers ; PLGA scaffolds ; Polyglactin 910 - chemistry ; Polypeptides ; Porosity ; Scaffolds ; Spectroscopy, Fourier Transform Infrared ; stem/progenitor cells ; surface modification ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgical implants ; Synthetic biopolymers ; Technology. Biomaterials. Equipments ; tissue engineering ; Tissue Engineering - methods ; Tissue Scaffolds - chemistry ; Tretinoin - chemistry</subject><ispartof>Journal of biomedical materials research. Part B, Applied biomaterials, 2013-11, Vol.101 (8), p.1329-1339</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4940-70a888399f4b18d47211165c59843f87c3c168dc8dc6f3458b5c66953718b8953</citedby><cites>FETCH-LOGICAL-c4940-70a888399f4b18d47211165c59843f87c3c168dc8dc6f3458b5c66953718b8953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.b.32950$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.b.32950$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27900608$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23687069$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Seong-Kyoon</creatorcontrib><creatorcontrib>Park, Jin-Kyu</creatorcontrib><creatorcontrib>Lee, Kyeong-Min</creatorcontrib><creatorcontrib>Lee, Soo-Keun</creatorcontrib><creatorcontrib>Jeon, Won Bae</creatorcontrib><title>Improved neural progenitor cell proliferation and differentiation on poly(lactide-co-glycolide) scaffolds coated with elastin-like polypeptide</title><title>Journal of biomedical materials research. Part B, Applied biomaterials</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Poly(lactide‐co‐glycolide) (PLGA) and elastin‐like polypeptide (ELP) have been widely used as a biodegradable scaffold and thermoresponsive matrix, respectively. However, little attention has focused on the combinatorial use of these biomaterials for tissue engineering applications. An ELP matrix TGPG[VGRGD(VGVPG)6]20WPC (referred to as REP) contains multiple Arg‐Gly‐Asp motifs. This study fabricated porous PLGA scaffolds coated with various concentration of matrix via thermally induced phase transition to improve adhesion‐mediated proliferation and differentiation of neural progenitor cells. Matrix‐coated scaffolds were characterized by FTIR, SEM, and hematoxylin and eosin staining with respect to coating efficiency, porosity, and pore size and shape. On the matrix‐coated scaffolds, cells grew as a single cell or associated each other to form a multicellular layer or cluster. In biological evaluations, cell adhesion and proliferation were significantly promoted in a matrix concentration‐dependent manner. More importantly, in combination with retinoic acid, the differentiation of progenitor cells into neuronal and astroglial lineages was highly stimulated in the cells cultured on matrix‐coated scaffolds than on untreated controls. Taken together, our results indicated that the REP matrix‐functionalized PLGA scaffolds are suitable for improving neuronal cell functions, and thus applicable for neural tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 101B: 1329–1339, 2013.</description><subject>Amino Acid Motifs</subject><subject>Aminoacid polymers</subject><subject>Applied sciences</subject><subject>Astrocytes - cytology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Biotechnology</subject><subject>Cell Adhesion</subject><subject>Cell Differentiation</subject><subject>Cell Lineage</subject><subject>Cell Proliferation</subject><subject>Cells (biology)</subject><subject>Coating</subject><subject>Combinatorial analysis</subject><subject>Differentiation</subject><subject>Elastin - chemistry</subject><subject>Exact sciences and technology</subject><subject>extracellular matrix</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health. Pharmaceutical industry</subject><subject>Humans</subject><subject>Industrial applications and implications. Economical aspects</subject><subject>Materials research</subject><subject>Materials science</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Neural Stem Cells - cytology</subject><subject>Peptides - chemistry</subject><subject>Physicochemistry of polymers</subject><subject>PLGA scaffolds</subject><subject>Polyglactin 910 - chemistry</subject><subject>Polypeptides</subject><subject>Porosity</subject><subject>Scaffolds</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>stem/progenitor cells</subject><subject>surface modification</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgical implants</subject><subject>Synthetic biopolymers</subject><subject>Technology. Biomaterials. Equipments</subject><subject>tissue engineering</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Scaffolds - chemistry</subject><subject>Tretinoin - chemistry</subject><issn>1552-4973</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhSMEoqWwYo8iIaQilMGO38s-aCkqsCkadpbjOMVTJw52Qjt_gt-MM5kOEgtAutL1tb5zj65Olj2HYAEBKN-uqnZRLVApCHiQ7UNCygILDh_u3gztZU9iXCWYAoIeZ3slopwBKvaznxdtH_wPU-edGYNyeZquTWcHH3Jt3GZ2tjFBDdZ3uerqvLZNmk032PkvVe_d-tApPdjaFNoX126tk6w2r_OoVdN4V8dcezUkn1s7fMuNU3GwXeHsjdmoe9NP4qfZo0a5aJ5t-0H25ezd1cn74vLz-cXJ0WWhscCgYEBxzpEQDa4grzErIYSUaCI4Rg1nGmlIea1T0QZhwiuiKRUEMcgrnvpBdjjvTed9H00cZGvjdK_qjB-jhJQxgTCG5X-gFJdg8v83SgDGhDAKE_ryD3Tlx9ClmyVknCKUFk7eb2ZKBx9jMI3sg21VWEsI5BS-TOHLSm7CT_SL7c6xak29Y-_TTsCrLaBSLK4JqtM2_uaYAIACnrhy5m6tM-u_ecoPxx-P792LWWTjYO52IhVuJGWIEbn8dC6XCJ59vQJLeYp-AUyy1lE</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Choi, Seong-Kyoon</creator><creator>Park, Jin-Kyu</creator><creator>Lee, Kyeong-Min</creator><creator>Lee, Soo-Keun</creator><creator>Jeon, Won Bae</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7T7</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>K9.</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201311</creationdate><title>Improved neural progenitor cell proliferation and differentiation on poly(lactide-co-glycolide) scaffolds coated with elastin-like polypeptide</title><author>Choi, Seong-Kyoon ; Park, Jin-Kyu ; Lee, Kyeong-Min ; Lee, Soo-Keun ; Jeon, Won Bae</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4940-70a888399f4b18d47211165c59843f87c3c168dc8dc6f3458b5c66953718b8953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Amino Acid Motifs</topic><topic>Aminoacid polymers</topic><topic>Applied sciences</topic><topic>Astrocytes - cytology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>Biomaterials</topic><topic>Biomedical materials</topic><topic>Biotechnology</topic><topic>Cell Adhesion</topic><topic>Cell Differentiation</topic><topic>Cell Lineage</topic><topic>Cell Proliferation</topic><topic>Cells (biology)</topic><topic>Coating</topic><topic>Combinatorial analysis</topic><topic>Differentiation</topic><topic>Elastin - chemistry</topic><topic>Exact sciences and technology</topic><topic>extracellular matrix</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health. Pharmaceutical industry</topic><topic>Humans</topic><topic>Industrial applications and implications. Economical aspects</topic><topic>Materials research</topic><topic>Materials science</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Neural Stem Cells - cytology</topic><topic>Peptides - chemistry</topic><topic>Physicochemistry of polymers</topic><topic>PLGA scaffolds</topic><topic>Polyglactin 910 - chemistry</topic><topic>Polypeptides</topic><topic>Porosity</topic><topic>Scaffolds</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>stem/progenitor cells</topic><topic>surface modification</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgical implants</topic><topic>Synthetic biopolymers</topic><topic>Technology. Biomaterials. Equipments</topic><topic>tissue engineering</topic><topic>Tissue Engineering - methods</topic><topic>Tissue Scaffolds - chemistry</topic><topic>Tretinoin - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Seong-Kyoon</creatorcontrib><creatorcontrib>Park, Jin-Kyu</creatorcontrib><creatorcontrib>Lee, Kyeong-Min</creatorcontrib><creatorcontrib>Lee, Soo-Keun</creatorcontrib><creatorcontrib>Jeon, Won Bae</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomedical materials research. Part B, Applied biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Seong-Kyoon</au><au>Park, Jin-Kyu</au><au>Lee, Kyeong-Min</au><au>Lee, Soo-Keun</au><au>Jeon, Won Bae</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved neural progenitor cell proliferation and differentiation on poly(lactide-co-glycolide) scaffolds coated with elastin-like polypeptide</atitle><jtitle>Journal of biomedical materials research. Part B, Applied biomaterials</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2013-11</date><risdate>2013</risdate><volume>101</volume><issue>8</issue><spage>1329</spage><epage>1339</epage><pages>1329-1339</pages><issn>1552-4973</issn><eissn>1552-4981</eissn><abstract>Poly(lactide‐co‐glycolide) (PLGA) and elastin‐like polypeptide (ELP) have been widely used as a biodegradable scaffold and thermoresponsive matrix, respectively. However, little attention has focused on the combinatorial use of these biomaterials for tissue engineering applications. An ELP matrix TGPG[VGRGD(VGVPG)6]20WPC (referred to as REP) contains multiple Arg‐Gly‐Asp motifs. This study fabricated porous PLGA scaffolds coated with various concentration of matrix via thermally induced phase transition to improve adhesion‐mediated proliferation and differentiation of neural progenitor cells. Matrix‐coated scaffolds were characterized by FTIR, SEM, and hematoxylin and eosin staining with respect to coating efficiency, porosity, and pore size and shape. On the matrix‐coated scaffolds, cells grew as a single cell or associated each other to form a multicellular layer or cluster. In biological evaluations, cell adhesion and proliferation were significantly promoted in a matrix concentration‐dependent manner. More importantly, in combination with retinoic acid, the differentiation of progenitor cells into neuronal and astroglial lineages was highly stimulated in the cells cultured on matrix‐coated scaffolds than on untreated controls. Taken together, our results indicated that the REP matrix‐functionalized PLGA scaffolds are suitable for improving neuronal cell functions, and thus applicable for neural tissue engineering. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 101B: 1329–1339, 2013.</abstract><cop>Hoboken, NJ</cop><pub>Blackwell Publishing Ltd</pub><pmid>23687069</pmid><doi>10.1002/jbm.b.32950</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1552-4973 |
| ispartof | Journal of biomedical materials research. Part B, Applied biomaterials, 2013-11, Vol.101 (8), p.1329-1339 |
| issn | 1552-4973 1552-4981 |
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| subjects | Amino Acid Motifs Aminoacid polymers Applied sciences Astrocytes - cytology Biological and medical sciences Biomarkers - metabolism Biomaterials Biomedical materials Biotechnology Cell Adhesion Cell Differentiation Cell Lineage Cell Proliferation Cells (biology) Coating Combinatorial analysis Differentiation Elastin - chemistry Exact sciences and technology extracellular matrix Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Materials research Materials science Medical sciences Miscellaneous Neural Stem Cells - cytology Peptides - chemistry Physicochemistry of polymers PLGA scaffolds Polyglactin 910 - chemistry Polypeptides Porosity Scaffolds Spectroscopy, Fourier Transform Infrared stem/progenitor cells surface modification Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical implants Synthetic biopolymers Technology. Biomaterials. Equipments tissue engineering Tissue Engineering - methods Tissue Scaffolds - chemistry Tretinoin - chemistry |
| title | Improved neural progenitor cell proliferation and differentiation on poly(lactide-co-glycolide) scaffolds coated with elastin-like polypeptide |
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