The interaction between cepharanthine and two serum albumins: multiple spectroscopic and chemometric investigations

ABSTRACT The binding modes of cepharanthine (CEPT) with bovine serum albumin (BSA) and human serum albumin (HSA) have been established by reproducing physiological conditions, which is very important to understand the pharmacokinetics and toxicity of CEPT. These spectral data were further analyzed b...

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Veröffentlicht in:	Luminescence (Chichester, England) England), 2014-08, Vol.29 (5), p.504-515
Hauptverfasser:	Cheng, Zhengjun, Liu, Rong, Jiang, Xiaohui, Xu, Qianyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - chemistry Benzylisoquinolines - chemistry Binding binding constants Bovine serum albumin Cattle cepharanthine Chemometrics Fluorescence Fluorescence Resonance Energy Transfer human serum albumin Humans Hydrophobic and Hydrophilic Interactions Kinetics multivariate curve resolution-alternating least squares Protein Binding Protein Structure, Secondary Serum albumin Serum Albumin - chemistry Serum Albumin, Bovine - chemistry Spectra Spectrum Analysis - instrumentation Spectrum Analysis - methods Thermodynamics Three dimensional Toxicity Tryptophan
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