Subcutaneous tissue reaction and cytotoxicity of polyvinylidene fluoride and polyvinylidene fluoride-trifluoroethylene blends associated with natural polymers
Cytotoxicity and subcutaneous tissue reaction of innovative blends composed by polyvinylidene fluoride and polyvinylidene fluoride‐trifluoroethylene associated with natural polymers (natural rubber and native starch) forming membranes were evaluated, aiming its applications associated with bone rege...
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| Veröffentlicht in: | Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2013-10, Vol.101 (7), p.1284-1293 |
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| creator | Marques, Leonardo Holgado, Leandro A. Simões, Rebeca D. Pereira, João D. A. S. Floriano, Juliana F. Mota, Lígia S. L. S. Graeff, Carlos F. O. Constantino, Carlos J. L. Rodriguez-Perez, Miguel. A. Matsumoto, Mariza Kinoshita, Angela |
| description | Cytotoxicity and subcutaneous tissue reaction of innovative blends composed by polyvinylidene fluoride and polyvinylidene fluoride‐trifluoroethylene associated with natural polymers (natural rubber and native starch) forming membranes were evaluated, aiming its applications associated with bone regeneration. Cytotoxicity was evaluated in mouse fibroblasts culture cells (NIH3T3) using trypan blue staining. Tissue response was in vivo evaluated by subcutaneous implantation of materials in rats, taking into account the presence of necrosis and connective tissue capsule around implanted materials after 7, 14, 21, 28, 35, 60, and 100 days of surgery. The pattern of inflammation was evaluated by histomorphometry of the inflammatory cells. Chemical and morphological changes of implanted materials after 60 and 100 days were evaluated by Fourier transform infrared (FTIR) absorption spectroscopy and scanning electron microscopy (SEM) images. Cytotoxicity tests indicated a good tolerance of the cells to the biomaterial. The in vivo tissue response of all studied materials showed normal inflammatory pattern, characterized by a reduction of polymorphonuclear leukocytes and an increase in mononuclear leukocytes over the time (p < 0.05 Kruskal–Wallis). On day 60, microscopic analysis showed regression of the chronic inflammatory process around all materials. FTIR showed no changes in chemical composition of materials due to implantation, whereas SEM demonstrated the delivery of starch in the medium. Therefore, the results of the tests performed in vitro and in vivo show that the innovative blends can further be used as biomaterials. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 1284–1293, 2013. |
| doi_str_mv | 10.1002/jbm.b.32941 |
| format | Article |
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A. S. ; Floriano, Juliana F. ; Mota, Lígia S. L. S. ; Graeff, Carlos F. O. ; Constantino, Carlos J. L. ; Rodriguez-Perez, Miguel. A. ; Matsumoto, Mariza ; Kinoshita, Angela</creator><creatorcontrib>Marques, Leonardo ; Holgado, Leandro A. ; Simões, Rebeca D. ; Pereira, João D. A. S. ; Floriano, Juliana F. ; Mota, Lígia S. L. S. ; Graeff, Carlos F. O. ; Constantino, Carlos J. L. ; Rodriguez-Perez, Miguel. A. ; Matsumoto, Mariza ; Kinoshita, Angela</creatorcontrib><description>Cytotoxicity and subcutaneous tissue reaction of innovative blends composed by polyvinylidene fluoride and polyvinylidene fluoride‐trifluoroethylene associated with natural polymers (natural rubber and native starch) forming membranes were evaluated, aiming its applications associated with bone regeneration. Cytotoxicity was evaluated in mouse fibroblasts culture cells (NIH3T3) using trypan blue staining. Tissue response was in vivo evaluated by subcutaneous implantation of materials in rats, taking into account the presence of necrosis and connective tissue capsule around implanted materials after 7, 14, 21, 28, 35, 60, and 100 days of surgery. The pattern of inflammation was evaluated by histomorphometry of the inflammatory cells. Chemical and morphological changes of implanted materials after 60 and 100 days were evaluated by Fourier transform infrared (FTIR) absorption spectroscopy and scanning electron microscopy (SEM) images. Cytotoxicity tests indicated a good tolerance of the cells to the biomaterial. The in vivo tissue response of all studied materials showed normal inflammatory pattern, characterized by a reduction of polymorphonuclear leukocytes and an increase in mononuclear leukocytes over the time (p < 0.05 Kruskal–Wallis). On day 60, microscopic analysis showed regression of the chronic inflammatory process around all materials. FTIR showed no changes in chemical composition of materials due to implantation, whereas SEM demonstrated the delivery of starch in the medium. Therefore, the results of the tests performed in vitro and in vivo show that the innovative blends can further be used as biomaterials. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 1284–1293, 2013.</description><identifier>ISSN: 1552-4973</identifier><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.b.32941</identifier><identifier>PMID: 23661490</identifier><language>eng</language><publisher>Hoboken, NJ: Blackwell Publishing Ltd</publisher><subject>Animals ; Biocompatibility ; Biological and medical sciences ; biomaterial ; Biomaterials ; Biomedical materials ; Bone Regeneration - drug effects ; cytotoxicity ; Fibroblasts - metabolism ; Fibroblasts - pathology ; Hydrocarbons, Fluorinated - adverse effects ; Hydrocarbons, Fluorinated - pharmacology ; In vivo testing ; In vivo tests ; Inflammation - chemically induced ; Inflammation - metabolism ; Inflammation - pathology ; Leukocytes, Mononuclear - metabolism ; Leukocytes, Mononuclear - pathology ; Male ; Materials Testing ; Medical sciences ; Mice ; Natural polymers ; NIH 3T3 Cells ; piezoelectricity ; Polymer blends ; Polyvinyls - adverse effects ; Polyvinyls - pharmacology ; PVDF ; Rats ; Rats, Wistar ; Scanning electron microscopy ; Starch - adverse effects ; Starch - pharmacology ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgical implants ; Technology. Biomaterials. Equipments ; tissue reaction ; Vinyl Compounds - adverse effects ; Vinyl Compounds - pharmacology</subject><ispartof>Journal of biomedical materials research. Part B, Applied biomaterials, 2013-10, Vol.101 (7), p.1284-1293</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4301-b0f1619c71735b82032fe23e21c7a5397d056ac84f825cfcc53dd998b7e31b643</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.b.32941$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.b.32941$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27779711$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23661490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marques, Leonardo</creatorcontrib><creatorcontrib>Holgado, Leandro A.</creatorcontrib><creatorcontrib>Simões, Rebeca D.</creatorcontrib><creatorcontrib>Pereira, João D. A. S.</creatorcontrib><creatorcontrib>Floriano, Juliana F.</creatorcontrib><creatorcontrib>Mota, Lígia S. L. S.</creatorcontrib><creatorcontrib>Graeff, Carlos F. O.</creatorcontrib><creatorcontrib>Constantino, Carlos J. L.</creatorcontrib><creatorcontrib>Rodriguez-Perez, Miguel. A.</creatorcontrib><creatorcontrib>Matsumoto, Mariza</creatorcontrib><creatorcontrib>Kinoshita, Angela</creatorcontrib><title>Subcutaneous tissue reaction and cytotoxicity of polyvinylidene fluoride and polyvinylidene fluoride-trifluoroethylene blends associated with natural polymers</title><title>Journal of biomedical materials research. Part B, Applied biomaterials</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Cytotoxicity and subcutaneous tissue reaction of innovative blends composed by polyvinylidene fluoride and polyvinylidene fluoride‐trifluoroethylene associated with natural polymers (natural rubber and native starch) forming membranes were evaluated, aiming its applications associated with bone regeneration. Cytotoxicity was evaluated in mouse fibroblasts culture cells (NIH3T3) using trypan blue staining. Tissue response was in vivo evaluated by subcutaneous implantation of materials in rats, taking into account the presence of necrosis and connective tissue capsule around implanted materials after 7, 14, 21, 28, 35, 60, and 100 days of surgery. The pattern of inflammation was evaluated by histomorphometry of the inflammatory cells. Chemical and morphological changes of implanted materials after 60 and 100 days were evaluated by Fourier transform infrared (FTIR) absorption spectroscopy and scanning electron microscopy (SEM) images. Cytotoxicity tests indicated a good tolerance of the cells to the biomaterial. The in vivo tissue response of all studied materials showed normal inflammatory pattern, characterized by a reduction of polymorphonuclear leukocytes and an increase in mononuclear leukocytes over the time (p < 0.05 Kruskal–Wallis). On day 60, microscopic analysis showed regression of the chronic inflammatory process around all materials. FTIR showed no changes in chemical composition of materials due to implantation, whereas SEM demonstrated the delivery of starch in the medium. Therefore, the results of the tests performed in vitro and in vivo show that the innovative blends can further be used as biomaterials. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 1284–1293, 2013.</description><subject>Animals</subject><subject>Biocompatibility</subject><subject>Biological and medical sciences</subject><subject>biomaterial</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Bone Regeneration - drug effects</subject><subject>cytotoxicity</subject><subject>Fibroblasts - metabolism</subject><subject>Fibroblasts - pathology</subject><subject>Hydrocarbons, Fluorinated - adverse effects</subject><subject>Hydrocarbons, Fluorinated - pharmacology</subject><subject>In vivo testing</subject><subject>In vivo tests</subject><subject>Inflammation - chemically induced</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - pathology</subject><subject>Leukocytes, Mononuclear - metabolism</subject><subject>Leukocytes, Mononuclear - pathology</subject><subject>Male</subject><subject>Materials Testing</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Natural polymers</subject><subject>NIH 3T3 Cells</subject><subject>piezoelectricity</subject><subject>Polymer blends</subject><subject>Polyvinyls - adverse effects</subject><subject>Polyvinyls - pharmacology</subject><subject>PVDF</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Scanning electron microscopy</subject><subject>Starch - adverse effects</subject><subject>Starch - pharmacology</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgical implants</subject><subject>Technology. Biomaterials. Equipments</subject><subject>tissue reaction</subject><subject>Vinyl Compounds - adverse effects</subject><subject>Vinyl Compounds - pharmacology</subject><issn>1552-4973</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkktv1DAUhSMEog9YsUfeIHWTwY_Yjpd0RFuqFiTeYmPZjqO6OPFgO7T5M_2tzWSmwwrBxj7S-c7VlX2K4gWCCwQhfn2tu4VeECwq9KjYR5TishI1erzTnOwVByldTzCDlDwt9jBhDFUC7hd3nwZthqx6G4YEsktpsCBaZbILPVB9A8yYQw63zrg8gtCCVfDjb9eP3jW2t6D1Q4iTnNm_eGWObtbB5qvRry09nU0CKqVgnMq2ATcuX4Fe5SEqPw_qbEzPiiet8sk-396HxZeTt5-XZ-XFh9N3yzcXpakIRKWGLWJIGI44obrGkODWYmIxMlxRIngDKVOmrtoaU9MaQ0nTCFFrbgnSrCKHxdFm7iqGX4NNWXYuGev95mEkYpwLgilD_4GyCgkuIP83WhGCORYCT-jLLTrozjZyFV2n4igffmoCXm0BlYzybVS9cekPx6cFOVqvhzfcjfN23PkIynVZ5FQWqeVcFnl-fHk8qylUbkIuZXu7C6n4UzJOOJXf3p_K5cnZ1-8fl-fyB7kHxzrFcQ</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Marques, Leonardo</creator><creator>Holgado, Leandro A.</creator><creator>Simões, Rebeca D.</creator><creator>Pereira, João D. A. S.</creator><creator>Floriano, Juliana F.</creator><creator>Mota, Lígia S. L. S.</creator><creator>Graeff, Carlos F. O.</creator><creator>Constantino, Carlos J. L.</creator><creator>Rodriguez-Perez, Miguel. A.</creator><creator>Matsumoto, Mariza</creator><creator>Kinoshita, Angela</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>201310</creationdate><title>Subcutaneous tissue reaction and cytotoxicity of polyvinylidene fluoride and polyvinylidene fluoride-trifluoroethylene blends associated with natural polymers</title><author>Marques, Leonardo ; Holgado, Leandro A. ; Simões, Rebeca D. ; Pereira, João D. A. S. ; Floriano, Juliana F. ; Mota, Lígia S. L. S. ; Graeff, Carlos F. O. ; Constantino, Carlos J. L. ; Rodriguez-Perez, Miguel. A. ; Matsumoto, Mariza ; Kinoshita, Angela</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4301-b0f1619c71735b82032fe23e21c7a5397d056ac84f825cfcc53dd998b7e31b643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Biocompatibility</topic><topic>Biological and medical sciences</topic><topic>biomaterial</topic><topic>Biomaterials</topic><topic>Biomedical materials</topic><topic>Bone Regeneration - drug effects</topic><topic>cytotoxicity</topic><topic>Fibroblasts - metabolism</topic><topic>Fibroblasts - pathology</topic><topic>Hydrocarbons, Fluorinated - adverse effects</topic><topic>Hydrocarbons, Fluorinated - pharmacology</topic><topic>In vivo testing</topic><topic>In vivo tests</topic><topic>Inflammation - chemically induced</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - pathology</topic><topic>Leukocytes, Mononuclear - metabolism</topic><topic>Leukocytes, Mononuclear - pathology</topic><topic>Male</topic><topic>Materials Testing</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Natural polymers</topic><topic>NIH 3T3 Cells</topic><topic>piezoelectricity</topic><topic>Polymer blends</topic><topic>Polyvinyls - adverse effects</topic><topic>Polyvinyls - pharmacology</topic><topic>PVDF</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Scanning electron microscopy</topic><topic>Starch - adverse effects</topic><topic>Starch - pharmacology</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgical implants</topic><topic>Technology. Biomaterials. Equipments</topic><topic>tissue reaction</topic><topic>Vinyl Compounds - adverse effects</topic><topic>Vinyl Compounds - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marques, Leonardo</creatorcontrib><creatorcontrib>Holgado, Leandro A.</creatorcontrib><creatorcontrib>Simões, Rebeca D.</creatorcontrib><creatorcontrib>Pereira, João D. A. S.</creatorcontrib><creatorcontrib>Floriano, Juliana F.</creatorcontrib><creatorcontrib>Mota, Lígia S. L. S.</creatorcontrib><creatorcontrib>Graeff, Carlos F. O.</creatorcontrib><creatorcontrib>Constantino, Carlos J. L.</creatorcontrib><creatorcontrib>Rodriguez-Perez, Miguel. 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Part B, Applied biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marques, Leonardo</au><au>Holgado, Leandro A.</au><au>Simões, Rebeca D.</au><au>Pereira, João D. A. S.</au><au>Floriano, Juliana F.</au><au>Mota, Lígia S. L. S.</au><au>Graeff, Carlos F. O.</au><au>Constantino, Carlos J. L.</au><au>Rodriguez-Perez, Miguel. A.</au><au>Matsumoto, Mariza</au><au>Kinoshita, Angela</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subcutaneous tissue reaction and cytotoxicity of polyvinylidene fluoride and polyvinylidene fluoride-trifluoroethylene blends associated with natural polymers</atitle><jtitle>Journal of biomedical materials research. Part B, Applied biomaterials</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2013-10</date><risdate>2013</risdate><volume>101</volume><issue>7</issue><spage>1284</spage><epage>1293</epage><pages>1284-1293</pages><issn>1552-4973</issn><eissn>1552-4981</eissn><abstract>Cytotoxicity and subcutaneous tissue reaction of innovative blends composed by polyvinylidene fluoride and polyvinylidene fluoride‐trifluoroethylene associated with natural polymers (natural rubber and native starch) forming membranes were evaluated, aiming its applications associated with bone regeneration. Cytotoxicity was evaluated in mouse fibroblasts culture cells (NIH3T3) using trypan blue staining. Tissue response was in vivo evaluated by subcutaneous implantation of materials in rats, taking into account the presence of necrosis and connective tissue capsule around implanted materials after 7, 14, 21, 28, 35, 60, and 100 days of surgery. The pattern of inflammation was evaluated by histomorphometry of the inflammatory cells. Chemical and morphological changes of implanted materials after 60 and 100 days were evaluated by Fourier transform infrared (FTIR) absorption spectroscopy and scanning electron microscopy (SEM) images. Cytotoxicity tests indicated a good tolerance of the cells to the biomaterial. The in vivo tissue response of all studied materials showed normal inflammatory pattern, characterized by a reduction of polymorphonuclear leukocytes and an increase in mononuclear leukocytes over the time (p < 0.05 Kruskal–Wallis). On day 60, microscopic analysis showed regression of the chronic inflammatory process around all materials. FTIR showed no changes in chemical composition of materials due to implantation, whereas SEM demonstrated the delivery of starch in the medium. Therefore, the results of the tests performed in vitro and in vivo show that the innovative blends can further be used as biomaterials. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 101B: 1284–1293, 2013.</abstract><cop>Hoboken, NJ</cop><pub>Blackwell Publishing Ltd</pub><pmid>23661490</pmid><doi>10.1002/jbm.b.32941</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of biomedical materials research. Part B, Applied biomaterials, 2013-10, Vol.101 (7), p.1284-1293 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Biocompatibility Biological and medical sciences biomaterial Biomaterials Biomedical materials Bone Regeneration - drug effects cytotoxicity Fibroblasts - metabolism Fibroblasts - pathology Hydrocarbons, Fluorinated - adverse effects Hydrocarbons, Fluorinated - pharmacology In vivo testing In vivo tests Inflammation - chemically induced Inflammation - metabolism Inflammation - pathology Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - pathology Male Materials Testing Medical sciences Mice Natural polymers NIH 3T3 Cells piezoelectricity Polymer blends Polyvinyls - adverse effects Polyvinyls - pharmacology PVDF Rats Rats, Wistar Scanning electron microscopy Starch - adverse effects Starch - pharmacology Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical implants Technology. Biomaterials. Equipments tissue reaction Vinyl Compounds - adverse effects Vinyl Compounds - pharmacology |
| title | Subcutaneous tissue reaction and cytotoxicity of polyvinylidene fluoride and polyvinylidene fluoride-trifluoroethylene blends associated with natural polymers |
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