pH-responsive lyotropic liquid crystals and their potential therapeutic role in cancer treatment

A weak amphiphilic base, pyridinylmethyl linoleate, is blended with monolinolein, yielding mesophases with a pH-induced hexagonal-to-cubic transition at pH ≤ 5.5. We show the potential therapeutic role of this mesophase in treating cancerous tissues exploiting their more acidic pH compared to health...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2015-04, Vol.51 (30), p.6671-6674
Hauptverfasser:	Negrini, Renata, Fong, Wye-Khay, Boyd, Ben J, Mezzenga, Raffaele
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cancer Cell Proliferation - drug effects Colon Doxorubicin - chemistry Doxorubicin - pharmacology Drug Carriers - chemistry Glycerides - chemistry HT29 Cells Human Humans Hydrogen-Ion Concentration Killing Linoleic Acid - chemistry Liquid crystals Liquid Crystals - chemistry Mesophase Strategy
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