pH-responsive lyotropic liquid crystals and their potential therapeutic role in cancer treatment
A weak amphiphilic base, pyridinylmethyl linoleate, is blended with monolinolein, yielding mesophases with a pH-induced hexagonal-to-cubic transition at pH ≤ 5.5. We show the potential therapeutic role of this mesophase in treating cancerous tissues exploiting their more acidic pH compared to health...
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| Veröffentlicht in: | Chemical communications (Cambridge, England) England), 2015-04, Vol.51 (30), p.6671-6674 |
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| container_end_page | 6674 |
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| container_issue | 30 |
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| container_title | Chemical communications (Cambridge, England) |
| container_volume | 51 |
| creator | Negrini, Renata Fong, Wye-Khay Boyd, Ben J Mezzenga, Raffaele |
| description | A weak amphiphilic base, pyridinylmethyl linoleate, is blended with monolinolein, yielding mesophases with a pH-induced hexagonal-to-cubic transition at pH ≤ 5.5. We show the potential therapeutic role of this mesophase in treating cancerous tissues exploiting their more acidic pH compared to healthy tissues. In vitro release studies with doxorubicin on HT29 human colon cancer cells show a 10-fold faster release and 3-fold increased efficiency for killing cancer cells at pH 5.5 versus pH 7.4, demonstrating the potential of this strategy in cancer treatment. |
| doi_str_mv | 10.1039/c4cc10274f |
| format | Article |
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| ispartof | Chemical communications (Cambridge, England), 2015-04, Vol.51 (30), p.6671-6674 |
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| source | MEDLINE; Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| subjects | Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cancer Cell Proliferation - drug effects Colon Doxorubicin - chemistry Doxorubicin - pharmacology Drug Carriers - chemistry Glycerides - chemistry HT29 Cells Human Humans Hydrogen-Ion Concentration Killing Linoleic Acid - chemistry Liquid crystals Liquid Crystals - chemistry Mesophase Strategy |
| title | pH-responsive lyotropic liquid crystals and their potential therapeutic role in cancer treatment |
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