Effects of the mold temperature on the mechanical properties and crystallinity of hydroxyapatite whisker-reinforced polyetheretherketone scaffolds
Porous and bioactive polyetheretherketone (PEEK) scaffolds have potential to replace metallic scaffolds for biologic fixation of permanent implants adjacent to trabecular bone, such as interbody spinal fusion devices. The objective of this study was to investigate the effects of the mold temperature...
Gespeichert in:
Veröffentlicht in: | Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2013-05, Vol.101B (4), p.576-583 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 583 |
---|---|
container_issue | 4 |
container_start_page | 576 |
container_title | Journal of biomedical materials research. Part B, Applied biomaterials |
container_volume | 101B |
creator | Conrad, Timothy L. Jaekel, David J. Kurtz, Steven M. Roeder, Ryan K. |
description | Porous and bioactive polyetheretherketone (PEEK) scaffolds have potential to replace metallic scaffolds for biologic fixation of permanent implants adjacent to trabecular bone, such as interbody spinal fusion devices. The objective of this study was to investigate the effects of the mold temperature and PEEK powder on the mechanical properties and crystallinity of hydroxyapatite (HA) whisker‐reinforced PEEK scaffolds prepared using compression molding and porogen leaching. Scaffolds were prepared at mold temperatures ranging 340–390°C with a 50 or 10 μm PEEK powder, 75 vol% porosity, and 20 vol% HA whiskers. Scaffold mechanical properties were evaluated in unconfined, uniaxial compression and the PEEK matrix crystallinity was measured using specular reflectance Fourier transform infrared spectroscopy. Increased mold temperature resulted in increased compressive modulus, yield strength, and yield strain, reaching a plateau at ∼370°C. HA reinforcements were observed to be segregated between PEEK particles, which inhibited PEEK particle coalescence during compression molding at temperatures less than 365°C but also ensured that bioactive HA reinforcements were exposed on scaffold strut surfaces. Increased mold temperature also resulted in decreased PEEK crystallinity, particularly for scaffolds molded at greater than 375°C. The PEEK powder size exhibited relatively minor effects on the scaffold mechanical properties and PEEK crystallinity. Therefore, the results of this study suggested that HA‐reinforced PEEK scaffolds should be compression molded at 370–375°C. The apparent compressive modulus, yield strength, and yield strain for scaffolds molded at 370–375°C was 75–92 MPa, 2.0–2.2 MPa, and 2.5–3.6%, respectively, which was within the range exhibited by human vertebral trabecular bone. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013. |
doi_str_mv | 10.1002/jbm.b.32859 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1677924906</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1677924906</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4659-d9afd882f7eab0142afb5a54e609d9c6d041edf15367ab17dfbbba65d1d5165e3</originalsourceid><addsrcrecordid>eNqNkUtv1DAUhSMEomVgxR55g4SEMthxbCdLWvVB1cIGBDvLj2uNO3lMbY_a_A1-cd1mOuyAja_l-91z5HuK4i3BS4Jx9ela90u9pFXD2mfFIWGsKuu2Ic_3d0EPilcxXmeYY0ZfFgcVrVouWH1Y_D5xDkyKaHQorQD1Y2dRgn4DQaVtADQO8zuYlRq8UR3ahDF3k4eI1GCRCVNMquv84NP0ILOabBjvJrVRySdAtysf1xDKAH5wYzBg0WbsJsiq4fFYQxoHQNEo57J7fF28cKqL8GZXF8WP05Pvx-fl5bezL8efL0tTc9aWtlXONk3lBCiNSV0pp5liNXDc2tZwi2sC1hFGuVCaCOu01oozSywjnAFdFB9m3fyhmy3EJHsfDXSdGmDcRkm4EG1Vt5j_B8rrCmNO8L9RWjGawxI0ox9n1IQxxgBOboLvVZgkwfIhWpmjlVo-Rpvpdzvhre7B7tmnLDPwfgeovMvOBTUYH_9w2bFu8joWBZm5W9_B9DdPeXF09WRezjM-Jrjbz6iwllxQweTPr2fyF746PRLNhRT0Hmxnzx4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1325332873</pqid></control><display><type>article</type><title>Effects of the mold temperature on the mechanical properties and crystallinity of hydroxyapatite whisker-reinforced polyetheretherketone scaffolds</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Conrad, Timothy L. ; Jaekel, David J. ; Kurtz, Steven M. ; Roeder, Ryan K.</creator><creatorcontrib>Conrad, Timothy L. ; Jaekel, David J. ; Kurtz, Steven M. ; Roeder, Ryan K.</creatorcontrib><description>Porous and bioactive polyetheretherketone (PEEK) scaffolds have potential to replace metallic scaffolds for biologic fixation of permanent implants adjacent to trabecular bone, such as interbody spinal fusion devices. The objective of this study was to investigate the effects of the mold temperature and PEEK powder on the mechanical properties and crystallinity of hydroxyapatite (HA) whisker‐reinforced PEEK scaffolds prepared using compression molding and porogen leaching. Scaffolds were prepared at mold temperatures ranging 340–390°C with a 50 or 10 μm PEEK powder, 75 vol% porosity, and 20 vol% HA whiskers. Scaffold mechanical properties were evaluated in unconfined, uniaxial compression and the PEEK matrix crystallinity was measured using specular reflectance Fourier transform infrared spectroscopy. Increased mold temperature resulted in increased compressive modulus, yield strength, and yield strain, reaching a plateau at ∼370°C. HA reinforcements were observed to be segregated between PEEK particles, which inhibited PEEK particle coalescence during compression molding at temperatures less than 365°C but also ensured that bioactive HA reinforcements were exposed on scaffold strut surfaces. Increased mold temperature also resulted in decreased PEEK crystallinity, particularly for scaffolds molded at greater than 375°C. The PEEK powder size exhibited relatively minor effects on the scaffold mechanical properties and PEEK crystallinity. Therefore, the results of this study suggested that HA‐reinforced PEEK scaffolds should be compression molded at 370–375°C. The apparent compressive modulus, yield strength, and yield strain for scaffolds molded at 370–375°C was 75–92 MPa, 2.0–2.2 MPa, and 2.5–3.6%, respectively, which was within the range exhibited by human vertebral trabecular bone. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.</description><identifier>ISSN: 1552-4973</identifier><identifier>EISSN: 1552-4981</identifier><identifier>DOI: 10.1002/jbm.b.32859</identifier><identifier>PMID: 23296754</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>biocomposite ; Biological and medical sciences ; Biomedical materials ; Bone and Bones - drug effects ; Bone and Bones - metabolism ; Bone Substitutes - chemistry ; Compressive Strength ; Crystallinity ; Crystallization ; Durapatite - chemistry ; Humans ; Hydroxyapatite ; Ketones - chemistry ; Materials Testing ; Mechanical properties ; Medical sciences ; Metals - chemistry ; Molds ; Particle Size ; polyetheretherketone ; Polyetheretherketones ; Polyethylene Glycols - chemistry ; Porosity ; Powders ; Pressure ; Pressure molding ; scaffold ; Scaffolds ; Spectroscopy, Fourier Transform Infrared ; Stress, Mechanical ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgical implants ; Technology. Biomaterials. Equipments ; Temperature ; whisker</subject><ispartof>Journal of biomedical materials research. Part B, Applied biomaterials, 2013-05, Vol.101B (4), p.576-583</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4659-d9afd882f7eab0142afb5a54e609d9c6d041edf15367ab17dfbbba65d1d5165e3</citedby><cites>FETCH-LOGICAL-c4659-d9afd882f7eab0142afb5a54e609d9c6d041edf15367ab17dfbbba65d1d5165e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjbm.b.32859$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjbm.b.32859$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27334815$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23296754$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Conrad, Timothy L.</creatorcontrib><creatorcontrib>Jaekel, David J.</creatorcontrib><creatorcontrib>Kurtz, Steven M.</creatorcontrib><creatorcontrib>Roeder, Ryan K.</creatorcontrib><title>Effects of the mold temperature on the mechanical properties and crystallinity of hydroxyapatite whisker-reinforced polyetheretherketone scaffolds</title><title>Journal of biomedical materials research. Part B, Applied biomaterials</title><addtitle>J. Biomed. Mater. Res</addtitle><description>Porous and bioactive polyetheretherketone (PEEK) scaffolds have potential to replace metallic scaffolds for biologic fixation of permanent implants adjacent to trabecular bone, such as interbody spinal fusion devices. The objective of this study was to investigate the effects of the mold temperature and PEEK powder on the mechanical properties and crystallinity of hydroxyapatite (HA) whisker‐reinforced PEEK scaffolds prepared using compression molding and porogen leaching. Scaffolds were prepared at mold temperatures ranging 340–390°C with a 50 or 10 μm PEEK powder, 75 vol% porosity, and 20 vol% HA whiskers. Scaffold mechanical properties were evaluated in unconfined, uniaxial compression and the PEEK matrix crystallinity was measured using specular reflectance Fourier transform infrared spectroscopy. Increased mold temperature resulted in increased compressive modulus, yield strength, and yield strain, reaching a plateau at ∼370°C. HA reinforcements were observed to be segregated between PEEK particles, which inhibited PEEK particle coalescence during compression molding at temperatures less than 365°C but also ensured that bioactive HA reinforcements were exposed on scaffold strut surfaces. Increased mold temperature also resulted in decreased PEEK crystallinity, particularly for scaffolds molded at greater than 375°C. The PEEK powder size exhibited relatively minor effects on the scaffold mechanical properties and PEEK crystallinity. Therefore, the results of this study suggested that HA‐reinforced PEEK scaffolds should be compression molded at 370–375°C. The apparent compressive modulus, yield strength, and yield strain for scaffolds molded at 370–375°C was 75–92 MPa, 2.0–2.2 MPa, and 2.5–3.6%, respectively, which was within the range exhibited by human vertebral trabecular bone. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.</description><subject>biocomposite</subject><subject>Biological and medical sciences</subject><subject>Biomedical materials</subject><subject>Bone and Bones - drug effects</subject><subject>Bone and Bones - metabolism</subject><subject>Bone Substitutes - chemistry</subject><subject>Compressive Strength</subject><subject>Crystallinity</subject><subject>Crystallization</subject><subject>Durapatite - chemistry</subject><subject>Humans</subject><subject>Hydroxyapatite</subject><subject>Ketones - chemistry</subject><subject>Materials Testing</subject><subject>Mechanical properties</subject><subject>Medical sciences</subject><subject>Metals - chemistry</subject><subject>Molds</subject><subject>Particle Size</subject><subject>polyetheretherketone</subject><subject>Polyetheretherketones</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Porosity</subject><subject>Powders</subject><subject>Pressure</subject><subject>Pressure molding</subject><subject>scaffold</subject><subject>Scaffolds</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Stress, Mechanical</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgical implants</subject><subject>Technology. Biomaterials. Equipments</subject><subject>Temperature</subject><subject>whisker</subject><issn>1552-4973</issn><issn>1552-4981</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtv1DAUhSMEomVgxR55g4SEMthxbCdLWvVB1cIGBDvLj2uNO3lMbY_a_A1-cd1mOuyAja_l-91z5HuK4i3BS4Jx9ela90u9pFXD2mfFIWGsKuu2Ic_3d0EPilcxXmeYY0ZfFgcVrVouWH1Y_D5xDkyKaHQorQD1Y2dRgn4DQaVtADQO8zuYlRq8UR3ahDF3k4eI1GCRCVNMquv84NP0ILOabBjvJrVRySdAtysf1xDKAH5wYzBg0WbsJsiq4fFYQxoHQNEo57J7fF28cKqL8GZXF8WP05Pvx-fl5bezL8efL0tTc9aWtlXONk3lBCiNSV0pp5liNXDc2tZwi2sC1hFGuVCaCOu01oozSywjnAFdFB9m3fyhmy3EJHsfDXSdGmDcRkm4EG1Vt5j_B8rrCmNO8L9RWjGawxI0ox9n1IQxxgBOboLvVZgkwfIhWpmjlVo-Rpvpdzvhre7B7tmnLDPwfgeovMvOBTUYH_9w2bFu8joWBZm5W9_B9DdPeXF09WRezjM-Jrjbz6iwllxQweTPr2fyF746PRLNhRT0Hmxnzx4</recordid><startdate>201305</startdate><enddate>201305</enddate><creator>Conrad, Timothy L.</creator><creator>Jaekel, David J.</creator><creator>Kurtz, Steven M.</creator><creator>Roeder, Ryan K.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7SR</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>F28</scope><scope>JG9</scope><scope>L7M</scope></search><sort><creationdate>201305</creationdate><title>Effects of the mold temperature on the mechanical properties and crystallinity of hydroxyapatite whisker-reinforced polyetheretherketone scaffolds</title><author>Conrad, Timothy L. ; Jaekel, David J. ; Kurtz, Steven M. ; Roeder, Ryan K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4659-d9afd882f7eab0142afb5a54e609d9c6d041edf15367ab17dfbbba65d1d5165e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>biocomposite</topic><topic>Biological and medical sciences</topic><topic>Biomedical materials</topic><topic>Bone and Bones - drug effects</topic><topic>Bone and Bones - metabolism</topic><topic>Bone Substitutes - chemistry</topic><topic>Compressive Strength</topic><topic>Crystallinity</topic><topic>Crystallization</topic><topic>Durapatite - chemistry</topic><topic>Humans</topic><topic>Hydroxyapatite</topic><topic>Ketones - chemistry</topic><topic>Materials Testing</topic><topic>Mechanical properties</topic><topic>Medical sciences</topic><topic>Metals - chemistry</topic><topic>Molds</topic><topic>Particle Size</topic><topic>polyetheretherketone</topic><topic>Polyetheretherketones</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Porosity</topic><topic>Powders</topic><topic>Pressure</topic><topic>Pressure molding</topic><topic>scaffold</topic><topic>Scaffolds</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Stress, Mechanical</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgical implants</topic><topic>Technology. Biomaterials. Equipments</topic><topic>Temperature</topic><topic>whisker</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Conrad, Timothy L.</creatorcontrib><creatorcontrib>Jaekel, David J.</creatorcontrib><creatorcontrib>Kurtz, Steven M.</creatorcontrib><creatorcontrib>Roeder, Ryan K.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Materials Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><jtitle>Journal of biomedical materials research. Part B, Applied biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Conrad, Timothy L.</au><au>Jaekel, David J.</au><au>Kurtz, Steven M.</au><au>Roeder, Ryan K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of the mold temperature on the mechanical properties and crystallinity of hydroxyapatite whisker-reinforced polyetheretherketone scaffolds</atitle><jtitle>Journal of biomedical materials research. Part B, Applied biomaterials</jtitle><addtitle>J. Biomed. Mater. Res</addtitle><date>2013-05</date><risdate>2013</risdate><volume>101B</volume><issue>4</issue><spage>576</spage><epage>583</epage><pages>576-583</pages><issn>1552-4973</issn><eissn>1552-4981</eissn><abstract>Porous and bioactive polyetheretherketone (PEEK) scaffolds have potential to replace metallic scaffolds for biologic fixation of permanent implants adjacent to trabecular bone, such as interbody spinal fusion devices. The objective of this study was to investigate the effects of the mold temperature and PEEK powder on the mechanical properties and crystallinity of hydroxyapatite (HA) whisker‐reinforced PEEK scaffolds prepared using compression molding and porogen leaching. Scaffolds were prepared at mold temperatures ranging 340–390°C with a 50 or 10 μm PEEK powder, 75 vol% porosity, and 20 vol% HA whiskers. Scaffold mechanical properties were evaluated in unconfined, uniaxial compression and the PEEK matrix crystallinity was measured using specular reflectance Fourier transform infrared spectroscopy. Increased mold temperature resulted in increased compressive modulus, yield strength, and yield strain, reaching a plateau at ∼370°C. HA reinforcements were observed to be segregated between PEEK particles, which inhibited PEEK particle coalescence during compression molding at temperatures less than 365°C but also ensured that bioactive HA reinforcements were exposed on scaffold strut surfaces. Increased mold temperature also resulted in decreased PEEK crystallinity, particularly for scaffolds molded at greater than 375°C. The PEEK powder size exhibited relatively minor effects on the scaffold mechanical properties and PEEK crystallinity. Therefore, the results of this study suggested that HA‐reinforced PEEK scaffolds should be compression molded at 370–375°C. The apparent compressive modulus, yield strength, and yield strain for scaffolds molded at 370–375°C was 75–92 MPa, 2.0–2.2 MPa, and 2.5–3.6%, respectively, which was within the range exhibited by human vertebral trabecular bone. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>23296754</pmid><doi>10.1002/jbm.b.32859</doi><tpages>8</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1552-4973 |
ispartof | Journal of biomedical materials research. Part B, Applied biomaterials, 2013-05, Vol.101B (4), p.576-583 |
issn | 1552-4973 1552-4981 |
language | eng |
recordid | cdi_proquest_miscellaneous_1677924906 |
source | MEDLINE; Access via Wiley Online Library |
subjects | biocomposite Biological and medical sciences Biomedical materials Bone and Bones - drug effects Bone and Bones - metabolism Bone Substitutes - chemistry Compressive Strength Crystallinity Crystallization Durapatite - chemistry Humans Hydroxyapatite Ketones - chemistry Materials Testing Mechanical properties Medical sciences Metals - chemistry Molds Particle Size polyetheretherketone Polyetheretherketones Polyethylene Glycols - chemistry Porosity Powders Pressure Pressure molding scaffold Scaffolds Spectroscopy, Fourier Transform Infrared Stress, Mechanical Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgical implants Technology. Biomaterials. Equipments Temperature whisker |
title | Effects of the mold temperature on the mechanical properties and crystallinity of hydroxyapatite whisker-reinforced polyetheretherketone scaffolds |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T11%3A36%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20the%20mold%20temperature%20on%20the%20mechanical%20properties%20and%20crystallinity%20of%20hydroxyapatite%20whisker-reinforced%20polyetheretherketone%20scaffolds&rft.jtitle=Journal%20of%20biomedical%20materials%20research.%20Part%20B,%20Applied%20biomaterials&rft.au=Conrad,%20Timothy%20L.&rft.date=2013-05&rft.volume=101B&rft.issue=4&rft.spage=576&rft.epage=583&rft.pages=576-583&rft.issn=1552-4973&rft.eissn=1552-4981&rft_id=info:doi/10.1002/jbm.b.32859&rft_dat=%3Cproquest_cross%3E1677924906%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1325332873&rft_id=info:pmid/23296754&rfr_iscdi=true |