Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281

Equilibrative nucleoside transporter subtype 1 (ENT1) is critical for the regulation of the biological activities of endogenous nucleosides such as adenosine, and for the cellular uptake of chemotherapeutic nucleoside analogs. Previous studies have implicated protein kinase C (PKC) in the regulation...

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Veröffentlicht in:	Cellular signalling 2015-05, Vol.27 (5), p.1008-1018
Hauptverfasser:	Hughes, Scott J., Cravetchi, Xenia, Vilas, Gonzalo, Hammond, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Adenosines Binding Cell Line Equilibrative Nucleoside Transporter 1 - metabolism Humans Kinase Kinases Membranes Mutagenesis Nucleoside Nucleosides Phosphorylation Protein Kinase C - metabolism Protein Transport Receptor, Adenosine A1 - metabolism Receptors Regulation Serine - metabolism Transport Transporter Uptakes
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