The Effect of Stabilizer on the Mechanical Response of Double-Emulsion-Templated Polymersomes
Recent studies have shown that polymersomes templated by microfluidic double‐emulsion possess several advantages such as high monodispersity and encapsulation efficiency compared with those generated based on thin‐film rehydration and electroformation. Stabilizers, including bovine serum albumin (BS...
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| Veröffentlicht in: | Macromolecular rapid communications. 2015-02, Vol.36 (4), p.378-384 |
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| creator | Jang, Woo-Sik Park, Seung Chul Kim, Miju Doh, Junsang Lee, Daeyeon Hammer, Daniel A. |
| description | Recent studies have shown that polymersomes templated by microfluidic double‐emulsion possess several advantages such as high monodispersity and encapsulation efficiency compared with those generated based on thin‐film rehydration and electroformation. Stabilizers, including bovine serum albumin (BSA) and polyvinyl alcohol (PVA), have been used to enhance the formation and stability of double emulsions that are used as templates for the generation of polymersomes. In this work, the effect of stabilizers on the mechanical response of double‐emulsion‐templated polymersomes using micropipette aspiration is investigated. It is demonstrated that the existence of stabilizers results in the inelastic response in polymersomes in the early stage of solvent removal. However, aged polymersomes that have little residual solvent show elastic behavior. Polymersomes prepared from PVA‐stabilized double emulsions have noticeably lower area expansion moduli than polymersomes prepared from stabilizer‐free and BSA‐stabilized double emulsions, suggesting that PVA is incorporated in the bilayer membrane of polymersomes.
Stabilizers are used to increase the stability of polymersomes templated by double emulsion. The comprehensive experimental study of effect of stabilizer on the mechanical response of double‐emulsion‐templated polymersomes membranes using micropipette aspiration is presented. Stabilizer‐free polymersomes show purely elastic behavior regardless of aging while polymersomes with stabilizer exhibit inelastic behavior in the early stage of solvent removal. |
| doi_str_mv | 10.1002/marc.201400472 |
| format | Article |
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Stabilizers are used to increase the stability of polymersomes templated by double emulsion. The comprehensive experimental study of effect of stabilizer on the mechanical response of double‐emulsion‐templated polymersomes membranes using micropipette aspiration is presented. Stabilizer‐free polymersomes show purely elastic behavior regardless of aging while polymersomes with stabilizer exhibit inelastic behavior in the early stage of solvent removal.</description><identifier>ISSN: 1022-1336</identifier><identifier>EISSN: 1521-3927</identifier><identifier>DOI: 10.1002/marc.201400472</identifier><identifier>PMID: 25515004</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Animals ; bovine serum albumin ; Cattle ; Double emulsions ; Elasticity ; Electroforming ; Emulsions - chemistry ; Encapsulation ; Membranes ; Microfluidic Analytical Techniques ; microfluidic double emulsion ; Microfluidics ; micropipette aspiration ; Oils - chemistry ; Polymers - chemistry ; polymersome ; polyvinyl alcohol ; Polyvinyl Alcohol - chemistry ; Polyvinyl alcohols ; Serum Albumin, Bovine - chemistry ; Serum Albumin, Bovine - metabolism ; Solvents ; Stability ; Time Factors</subject><ispartof>Macromolecular rapid communications., 2015-02, Vol.36 (4), p.378-384</ispartof><rights>2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>Copyright 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5512-1991cad4a5fb027edb8a72f8dec4e2999a099eef35902bb7b4d7671963df3a803</citedby><cites>FETCH-LOGICAL-c5512-1991cad4a5fb027edb8a72f8dec4e2999a099eef35902bb7b4d7671963df3a803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmarc.201400472$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmarc.201400472$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25515004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jang, Woo-Sik</creatorcontrib><creatorcontrib>Park, Seung Chul</creatorcontrib><creatorcontrib>Kim, Miju</creatorcontrib><creatorcontrib>Doh, Junsang</creatorcontrib><creatorcontrib>Lee, Daeyeon</creatorcontrib><creatorcontrib>Hammer, Daniel A.</creatorcontrib><title>The Effect of Stabilizer on the Mechanical Response of Double-Emulsion-Templated Polymersomes</title><title>Macromolecular rapid communications.</title><addtitle>Macromol. Rapid Commun</addtitle><description>Recent studies have shown that polymersomes templated by microfluidic double‐emulsion possess several advantages such as high monodispersity and encapsulation efficiency compared with those generated based on thin‐film rehydration and electroformation. Stabilizers, including bovine serum albumin (BSA) and polyvinyl alcohol (PVA), have been used to enhance the formation and stability of double emulsions that are used as templates for the generation of polymersomes. In this work, the effect of stabilizers on the mechanical response of double‐emulsion‐templated polymersomes using micropipette aspiration is investigated. It is demonstrated that the existence of stabilizers results in the inelastic response in polymersomes in the early stage of solvent removal. However, aged polymersomes that have little residual solvent show elastic behavior. Polymersomes prepared from PVA‐stabilized double emulsions have noticeably lower area expansion moduli than polymersomes prepared from stabilizer‐free and BSA‐stabilized double emulsions, suggesting that PVA is incorporated in the bilayer membrane of polymersomes.
Stabilizers are used to increase the stability of polymersomes templated by double emulsion. The comprehensive experimental study of effect of stabilizer on the mechanical response of double‐emulsion‐templated polymersomes membranes using micropipette aspiration is presented. Stabilizer‐free polymersomes show purely elastic behavior regardless of aging while polymersomes with stabilizer exhibit inelastic behavior in the early stage of solvent removal.</description><subject>Animals</subject><subject>bovine serum albumin</subject><subject>Cattle</subject><subject>Double emulsions</subject><subject>Elasticity</subject><subject>Electroforming</subject><subject>Emulsions - chemistry</subject><subject>Encapsulation</subject><subject>Membranes</subject><subject>Microfluidic Analytical Techniques</subject><subject>microfluidic double emulsion</subject><subject>Microfluidics</subject><subject>micropipette aspiration</subject><subject>Oils - chemistry</subject><subject>Polymers - chemistry</subject><subject>polymersome</subject><subject>polyvinyl alcohol</subject><subject>Polyvinyl Alcohol - chemistry</subject><subject>Polyvinyl alcohols</subject><subject>Serum Albumin, Bovine - chemistry</subject><subject>Serum Albumin, Bovine - metabolism</subject><subject>Solvents</subject><subject>Stability</subject><subject>Time Factors</subject><issn>1022-1336</issn><issn>1521-3927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFrFDEUhwdRbK1ePcqAl15mTV4mk8mxrNtW2FZptxQECZnMC52amazJDHb715tl6yJe9PQC7_v9eOHLsreUzCgh8KHXwcyA0JKQUsCz7JByoAWTIJ6nNwEoKGPVQfYqxntCSF0SeJkdAOeUp8Rh9m11h_nCWjRj7m1-Peqmc90jhtwP-Zh2F2ju9NAZ7fIrjGs_RNyCH_3UOCwW_eRi54dihf3a6RHb_It3mx5D9D3G19kLq13EN0_zKLs5Xazm58Xy89mn-cmyMOmQdKKU1Oi21Nw2BAS2Ta0F2LpFUyJIKTWREtEyLgk0jWjKVlSCyoq1lumasKPseNe7Dv7HhHFUfRcNOqcH9FNUtBJCApHl_6CccwABdULf_4Xe-ykM6SNbqqylAKgSNdtRJvgYA1q1Dl3SslGUqK0jtXWk9o5S4N1T7dT02O7x31ISIHfAz87h5h916uLkav5nebHLdnHEh31Wh--qEkxwdXt5pq6X51yu6KX6yn4BeWarzw</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Jang, Woo-Sik</creator><creator>Park, Seung Chul</creator><creator>Kim, Miju</creator><creator>Doh, Junsang</creator><creator>Lee, Daeyeon</creator><creator>Hammer, Daniel A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>7U5</scope><scope>8FD</scope><scope>JG9</scope><scope>JQ2</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>201502</creationdate><title>The Effect of Stabilizer on the Mechanical Response of Double-Emulsion-Templated Polymersomes</title><author>Jang, Woo-Sik ; Park, Seung Chul ; Kim, Miju ; Doh, Junsang ; Lee, Daeyeon ; Hammer, Daniel A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5512-1991cad4a5fb027edb8a72f8dec4e2999a099eef35902bb7b4d7671963df3a803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>bovine serum albumin</topic><topic>Cattle</topic><topic>Double emulsions</topic><topic>Elasticity</topic><topic>Electroforming</topic><topic>Emulsions - chemistry</topic><topic>Encapsulation</topic><topic>Membranes</topic><topic>Microfluidic Analytical Techniques</topic><topic>microfluidic double emulsion</topic><topic>Microfluidics</topic><topic>micropipette aspiration</topic><topic>Oils - chemistry</topic><topic>Polymers - chemistry</topic><topic>polymersome</topic><topic>polyvinyl alcohol</topic><topic>Polyvinyl Alcohol - chemistry</topic><topic>Polyvinyl alcohols</topic><topic>Serum Albumin, Bovine - chemistry</topic><topic>Serum Albumin, Bovine - metabolism</topic><topic>Solvents</topic><topic>Stability</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jang, Woo-Sik</creatorcontrib><creatorcontrib>Park, Seung Chul</creatorcontrib><creatorcontrib>Kim, Miju</creatorcontrib><creatorcontrib>Doh, Junsang</creatorcontrib><creatorcontrib>Lee, Daeyeon</creatorcontrib><creatorcontrib>Hammer, Daniel A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Macromolecular rapid communications.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jang, Woo-Sik</au><au>Park, Seung Chul</au><au>Kim, Miju</au><au>Doh, Junsang</au><au>Lee, Daeyeon</au><au>Hammer, Daniel A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Stabilizer on the Mechanical Response of Double-Emulsion-Templated Polymersomes</atitle><jtitle>Macromolecular rapid communications.</jtitle><addtitle>Macromol. Rapid Commun</addtitle><date>2015-02</date><risdate>2015</risdate><volume>36</volume><issue>4</issue><spage>378</spage><epage>384</epage><pages>378-384</pages><issn>1022-1336</issn><eissn>1521-3927</eissn><abstract>Recent studies have shown that polymersomes templated by microfluidic double‐emulsion possess several advantages such as high monodispersity and encapsulation efficiency compared with those generated based on thin‐film rehydration and electroformation. Stabilizers, including bovine serum albumin (BSA) and polyvinyl alcohol (PVA), have been used to enhance the formation and stability of double emulsions that are used as templates for the generation of polymersomes. In this work, the effect of stabilizers on the mechanical response of double‐emulsion‐templated polymersomes using micropipette aspiration is investigated. It is demonstrated that the existence of stabilizers results in the inelastic response in polymersomes in the early stage of solvent removal. However, aged polymersomes that have little residual solvent show elastic behavior. Polymersomes prepared from PVA‐stabilized double emulsions have noticeably lower area expansion moduli than polymersomes prepared from stabilizer‐free and BSA‐stabilized double emulsions, suggesting that PVA is incorporated in the bilayer membrane of polymersomes.
Stabilizers are used to increase the stability of polymersomes templated by double emulsion. The comprehensive experimental study of effect of stabilizer on the mechanical response of double‐emulsion‐templated polymersomes membranes using micropipette aspiration is presented. Stabilizer‐free polymersomes show purely elastic behavior regardless of aging while polymersomes with stabilizer exhibit inelastic behavior in the early stage of solvent removal.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>25515004</pmid><doi>10.1002/marc.201400472</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals bovine serum albumin Cattle Double emulsions Elasticity Electroforming Emulsions - chemistry Encapsulation Membranes Microfluidic Analytical Techniques microfluidic double emulsion Microfluidics micropipette aspiration Oils - chemistry Polymers - chemistry polymersome polyvinyl alcohol Polyvinyl Alcohol - chemistry Polyvinyl alcohols Serum Albumin, Bovine - chemistry Serum Albumin, Bovine - metabolism Solvents Stability Time Factors |
| title | The Effect of Stabilizer on the Mechanical Response of Double-Emulsion-Templated Polymersomes |
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