On the noninvasive optical monitoring and differentiation of methemoglobinemia and sulfhemoglobinemia
There are several pathologies whose study and diagnosis is impaired by a relatively small number of documented cases. A practical approach to overcome this obstacle and advance the research in this area consists in employing computer simulations to perform controlled in silico experiments. The resul...
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| Veröffentlicht in: | Journal of biomedical optics 2012-09, Vol.17 (9), p.97005-1-097005-14 |
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| container_end_page | 1-097005-14 |
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| container_issue | 9 |
| container_start_page | 97005 |
| container_title | Journal of biomedical optics |
| container_volume | 17 |
| creator | Baranoski, Gladimir V G Chen, Tenn F Kimmel, Bradley W Miranda, Erik Yim, Daniel |
| description | There are several pathologies whose study and diagnosis is impaired by a relatively small number of documented cases. A practical approach to overcome this obstacle and advance the research in this area consists in employing computer simulations to perform controlled in silico experiments. The results of these experiments, in turn, may be incorporated in the design of differential protocols for these pathologies. Accordingly, in this paper, we investigate the spectral responses of human skin affected by the presence of abnormal amounts of two dysfunctional hemoglobins, methemoglobin and sulfhemoglobin, which are associated with two life-threatening medical conditions, methemoglobinemia and sulfhemoglobinemia, respectively. We analyze the results of our in silico experiments and discuss their potential applications to the development of more effective noninvasive monitoring and differentiation procedures for these medical conditions. |
| doi_str_mv | 10.1117/1.JBO.17.9.097005 |
| format | Article |
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| issn | 1083-3668 1560-2281 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Computer simulation Diagnosis, Computer-Assisted - methods Diagnosis, Differential Differentiation Hemoglobin Hemoglobins - analysis Human Medical Methemoglobinemia - diagnosis Methemoglobinemia - metabolism Monitoring Pathology Reproducibility of Results Sensitivity and Specificity Skin - metabolism Spectra Spectrum Analysis - methods Sulfhemoglobinemia - diagnosis Sulfhemoglobinemia - metabolism |
| title | On the noninvasive optical monitoring and differentiation of methemoglobinemia and sulfhemoglobinemia |
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