Acute modulation of the cholinergic system in the mouse brain detected by pharmacological resting-state functional MRI

The cholinergic system is involved in learning and memory and is affected in neurodegenerative disorders such as Alzheimer's disease. The possibility of non-invasively detecting alterations of neurotransmitter systems in the mouse brain would greatly improve early diagnosis and treatment strate...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2015-04, Vol.109, p.151-159
Hauptverfasser:	Shah, Disha, Blockx, Ines, Guns, Pieter-Jan, De Deyn, Peter Paul, Van Dam, Debby, Jonckers, Elisabeth, Delgado y Palacios, Rafael, Verhoye, Marleen, Van der Linden, Annemie
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Agreements Alterations Alzheimer's disease Animals Brain Brain - drug effects Brain - metabolism Cholinergic Antagonists - pharmacology Cholinergics Cortexes Disorders Image Processing, Computer-Assisted Magnetic Resonance Imaging - methods Male Mice Mice, Inbred C57BL Modulation Neural Pathways - drug effects Neural Pathways - physiology Neurotransmitters NMR Nuclear magnetic resonance Pathology Rest Rodents Studies Synaptic Transmission - drug effects Synaptic Transmission - physiology
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