Ileal pouch morphology and microbiology in ulcerative colitis patients
Ideal pouch created during restorative proctocolectomy is a new gastrointestinal organ--"neorectum". Although it is made from the ileum, it takes over function of the removed rectum. This new function results in significant morphological changes in pouch's mucous membrane, which becom...
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| Veröffentlicht in: | Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2015-03, Vol.24 (2), p.267-274 |
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| container_title | Advances in clinical and experimental medicine : official organ Wroclaw Medical University |
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| creator | Pawełka, Dorota Bednarz, Wiktor Krawczyk, Zbigniew Rzeszutko, Marta Olewiński, Robert Czopnik, Piotr |
| description | Ideal pouch created during restorative proctocolectomy is a new gastrointestinal organ--"neorectum". Although it is made from the ileum, it takes over function of the removed rectum. This new function results in significant morphological changes in pouch's mucous membrane, which becomes similar to the large bowel mucosa. The most common pathology of the ileal pouch is its inflammation--pouchitis. One of the suspected causes of pouchitis is bacterial flora disturbance.
The aim of the study was to analyze the morphological and microbiological changes in ileal pouches in different time periods after ileostomy closure and to evaluate the influence of certain bacterial strains on the degree of inflammation.
The study involved 47 patients who had been treated surgically; they were investigated before and at different stages after ileostomy closure. They underwent repeated rectoscopies with biopsies of pouch mucosa and swabs for microbiological examination. In total 89 rectoscopies were performed, which provided 70 histopathological results according to the Heidelberg Pouchitis Activity Score and 87 microbiological test results.
The assessment of the morphology of intestinal pouches showed increased signs of chronic inflammation as the length of time after the closure of a protective ileostomy increased. There was no correlation between the signs of acute inflammation and the length of time after surgery; there were more signs of acute inflammation in cases of pouchitis. The composition of the bacterial flora of intestinal pouches changed as the length of time after ileostomy closure increased, with significant increases in the number of enterobacteriaceae species. The presence of Staphylococcus aureus significantly correlates with a higher degree of chronic inflammation; this bacterium may be a potential infectious factor in pouchitis.
Microbiological analysis of intestinal pouch lumen is a useful tool that can be used in routine follow-up assessment of intestinal pouches as well as in diagnosing pouchitis. |
| doi_str_mv | 10.17219/acem/40399 |
| format | Article |
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The aim of the study was to analyze the morphological and microbiological changes in ileal pouches in different time periods after ileostomy closure and to evaluate the influence of certain bacterial strains on the degree of inflammation.
The study involved 47 patients who had been treated surgically; they were investigated before and at different stages after ileostomy closure. They underwent repeated rectoscopies with biopsies of pouch mucosa and swabs for microbiological examination. In total 89 rectoscopies were performed, which provided 70 histopathological results according to the Heidelberg Pouchitis Activity Score and 87 microbiological test results.
The assessment of the morphology of intestinal pouches showed increased signs of chronic inflammation as the length of time after the closure of a protective ileostomy increased. There was no correlation between the signs of acute inflammation and the length of time after surgery; there were more signs of acute inflammation in cases of pouchitis. The composition of the bacterial flora of intestinal pouches changed as the length of time after ileostomy closure increased, with significant increases in the number of enterobacteriaceae species. The presence of Staphylococcus aureus significantly correlates with a higher degree of chronic inflammation; this bacterium may be a potential infectious factor in pouchitis.
Microbiological analysis of intestinal pouch lumen is a useful tool that can be used in routine follow-up assessment of intestinal pouches as well as in diagnosing pouchitis.</description><identifier>ISSN: 1899-5276</identifier><identifier>DOI: 10.17219/acem/40399</identifier><identifier>PMID: 25931359</identifier><language>eng</language><publisher>Poland</publisher><subject>Biopsy ; Colitis, Ulcerative - diagnosis ; Colitis, Ulcerative - microbiology ; Colitis, Ulcerative - surgery ; Colonic Pouches - adverse effects ; Colonic Pouches - microbiology ; Endoscopy, Gastrointestinal ; Female ; Humans ; Intestinal Mucosa - microbiology ; Intestinal Mucosa - pathology ; Intestinal Mucosa - surgery ; Male ; Pouchitis - diagnosis ; Pouchitis - microbiology ; Predictive Value of Tests ; Proctocolectomy, Restorative - adverse effects ; Severity of Illness Index ; Time Factors ; Treatment Outcome</subject><ispartof>Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2015-03, Vol.24 (2), p.267-274</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c326t-e6e40a332111f01d8699df31cb79c1380badc640b67d5f6d8d81380638b0d53a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25931359$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pawełka, Dorota</creatorcontrib><creatorcontrib>Bednarz, Wiktor</creatorcontrib><creatorcontrib>Krawczyk, Zbigniew</creatorcontrib><creatorcontrib>Rzeszutko, Marta</creatorcontrib><creatorcontrib>Olewiński, Robert</creatorcontrib><creatorcontrib>Czopnik, Piotr</creatorcontrib><title>Ileal pouch morphology and microbiology in ulcerative colitis patients</title><title>Advances in clinical and experimental medicine : official organ Wroclaw Medical University</title><addtitle>Adv Clin Exp Med</addtitle><description>Ideal pouch created during restorative proctocolectomy is a new gastrointestinal organ--"neorectum". Although it is made from the ileum, it takes over function of the removed rectum. This new function results in significant morphological changes in pouch's mucous membrane, which becomes similar to the large bowel mucosa. The most common pathology of the ileal pouch is its inflammation--pouchitis. One of the suspected causes of pouchitis is bacterial flora disturbance.
The aim of the study was to analyze the morphological and microbiological changes in ileal pouches in different time periods after ileostomy closure and to evaluate the influence of certain bacterial strains on the degree of inflammation.
The study involved 47 patients who had been treated surgically; they were investigated before and at different stages after ileostomy closure. They underwent repeated rectoscopies with biopsies of pouch mucosa and swabs for microbiological examination. In total 89 rectoscopies were performed, which provided 70 histopathological results according to the Heidelberg Pouchitis Activity Score and 87 microbiological test results.
The assessment of the morphology of intestinal pouches showed increased signs of chronic inflammation as the length of time after the closure of a protective ileostomy increased. There was no correlation between the signs of acute inflammation and the length of time after surgery; there were more signs of acute inflammation in cases of pouchitis. The composition of the bacterial flora of intestinal pouches changed as the length of time after ileostomy closure increased, with significant increases in the number of enterobacteriaceae species. The presence of Staphylococcus aureus significantly correlates with a higher degree of chronic inflammation; this bacterium may be a potential infectious factor in pouchitis.
Microbiological analysis of intestinal pouch lumen is a useful tool that can be used in routine follow-up assessment of intestinal pouches as well as in diagnosing pouchitis.</description><subject>Biopsy</subject><subject>Colitis, Ulcerative - diagnosis</subject><subject>Colitis, Ulcerative - microbiology</subject><subject>Colitis, Ulcerative - surgery</subject><subject>Colonic Pouches - adverse effects</subject><subject>Colonic Pouches - microbiology</subject><subject>Endoscopy, Gastrointestinal</subject><subject>Female</subject><subject>Humans</subject><subject>Intestinal Mucosa - microbiology</subject><subject>Intestinal Mucosa - pathology</subject><subject>Intestinal Mucosa - surgery</subject><subject>Male</subject><subject>Pouchitis - diagnosis</subject><subject>Pouchitis - microbiology</subject><subject>Predictive Value of Tests</subject><subject>Proctocolectomy, Restorative - adverse effects</subject><subject>Severity of Illness Index</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1899-5276</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LxDAQhnNQ3GXdk3fJUZC6maZNk6MsrgoLXvQc0iR1I2lTk1bYf2_3Q-cyzMvDC_MgdAPkAaocxEpp264KQoW4QHPgQmRlXrEZWqb0RaYpRC5IcYVmeSko0FLM0ebVW-VxH0a9w22I_S748LnHqjO4dTqG2p0C1-HRaxvV4H4s1sG7wSXcT6fthnSNLhvlk12e9wJ9bJ7e1y_Z9u35df24zTTN2ZBZZguiKM0BoCFgOBPCNBR0XQkNlJNaGc0KUrPKlA0z3PBDyiiviSmpogt0d-rtY_gebRpk65K23qvOhjFJYFXFRQG8nND7Ezo9kVK0jeyja1XcSyDy6EsefMmjr4m-PRePdWvNP_tniv4Cq4ZoIQ</recordid><startdate>20150301</startdate><enddate>20150301</enddate><creator>Pawełka, Dorota</creator><creator>Bednarz, Wiktor</creator><creator>Krawczyk, Zbigniew</creator><creator>Rzeszutko, Marta</creator><creator>Olewiński, Robert</creator><creator>Czopnik, Piotr</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150301</creationdate><title>Ileal pouch morphology and microbiology in ulcerative colitis patients</title><author>Pawełka, Dorota ; Bednarz, Wiktor ; Krawczyk, Zbigniew ; Rzeszutko, Marta ; Olewiński, Robert ; Czopnik, Piotr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-e6e40a332111f01d8699df31cb79c1380badc640b67d5f6d8d81380638b0d53a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Biopsy</topic><topic>Colitis, Ulcerative - diagnosis</topic><topic>Colitis, Ulcerative - microbiology</topic><topic>Colitis, Ulcerative - surgery</topic><topic>Colonic Pouches - adverse effects</topic><topic>Colonic Pouches - microbiology</topic><topic>Endoscopy, Gastrointestinal</topic><topic>Female</topic><topic>Humans</topic><topic>Intestinal Mucosa - microbiology</topic><topic>Intestinal Mucosa - pathology</topic><topic>Intestinal Mucosa - surgery</topic><topic>Male</topic><topic>Pouchitis - diagnosis</topic><topic>Pouchitis - microbiology</topic><topic>Predictive Value of Tests</topic><topic>Proctocolectomy, Restorative - adverse effects</topic><topic>Severity of Illness Index</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pawełka, Dorota</creatorcontrib><creatorcontrib>Bednarz, Wiktor</creatorcontrib><creatorcontrib>Krawczyk, Zbigniew</creatorcontrib><creatorcontrib>Rzeszutko, Marta</creatorcontrib><creatorcontrib>Olewiński, Robert</creatorcontrib><creatorcontrib>Czopnik, Piotr</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Advances in clinical and experimental medicine : official organ Wroclaw Medical University</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pawełka, Dorota</au><au>Bednarz, Wiktor</au><au>Krawczyk, Zbigniew</au><au>Rzeszutko, Marta</au><au>Olewiński, Robert</au><au>Czopnik, Piotr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ileal pouch morphology and microbiology in ulcerative colitis patients</atitle><jtitle>Advances in clinical and experimental medicine : official organ Wroclaw Medical University</jtitle><addtitle>Adv Clin Exp Med</addtitle><date>2015-03-01</date><risdate>2015</risdate><volume>24</volume><issue>2</issue><spage>267</spage><epage>274</epage><pages>267-274</pages><issn>1899-5276</issn><abstract>Ideal pouch created during restorative proctocolectomy is a new gastrointestinal organ--"neorectum". Although it is made from the ileum, it takes over function of the removed rectum. This new function results in significant morphological changes in pouch's mucous membrane, which becomes similar to the large bowel mucosa. The most common pathology of the ileal pouch is its inflammation--pouchitis. One of the suspected causes of pouchitis is bacterial flora disturbance.
The aim of the study was to analyze the morphological and microbiological changes in ileal pouches in different time periods after ileostomy closure and to evaluate the influence of certain bacterial strains on the degree of inflammation.
The study involved 47 patients who had been treated surgically; they were investigated before and at different stages after ileostomy closure. They underwent repeated rectoscopies with biopsies of pouch mucosa and swabs for microbiological examination. In total 89 rectoscopies were performed, which provided 70 histopathological results according to the Heidelberg Pouchitis Activity Score and 87 microbiological test results.
The assessment of the morphology of intestinal pouches showed increased signs of chronic inflammation as the length of time after the closure of a protective ileostomy increased. There was no correlation between the signs of acute inflammation and the length of time after surgery; there were more signs of acute inflammation in cases of pouchitis. The composition of the bacterial flora of intestinal pouches changed as the length of time after ileostomy closure increased, with significant increases in the number of enterobacteriaceae species. The presence of Staphylococcus aureus significantly correlates with a higher degree of chronic inflammation; this bacterium may be a potential infectious factor in pouchitis.
Microbiological analysis of intestinal pouch lumen is a useful tool that can be used in routine follow-up assessment of intestinal pouches as well as in diagnosing pouchitis.</abstract><cop>Poland</cop><pmid>25931359</pmid><doi>10.17219/acem/40399</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biopsy Colitis, Ulcerative - diagnosis Colitis, Ulcerative - microbiology Colitis, Ulcerative - surgery Colonic Pouches - adverse effects Colonic Pouches - microbiology Endoscopy, Gastrointestinal Female Humans Intestinal Mucosa - microbiology Intestinal Mucosa - pathology Intestinal Mucosa - surgery Male Pouchitis - diagnosis Pouchitis - microbiology Predictive Value of Tests Proctocolectomy, Restorative - adverse effects Severity of Illness Index Time Factors Treatment Outcome |
| title | Ileal pouch morphology and microbiology in ulcerative colitis patients |
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