Research of suppression of the herpes simplex virus reproduction with drug resistance by combination phosphite of acycloguanosine with some antiherpetic drugs
The activity of the phosphite of acycloguanosine (P-ACG) and six antivirals was tested individually and in double and triple combinations on two strains of the herpes simplex virus (HSV) type 1 (sensitive to acyclovir and resistant to acyclovir) using the CPE inhibition method in the Vero E6 cell mi...
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| Veröffentlicht in: | Voprosy virusologiĭ 2014, Vol.59 (6), p.32-35 |
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| creator | Andronova, V L Jasko, M V Kukhanova, M K Skoblov, Yu S Deryabin, P G Galegov, G A |
| description | The activity of the phosphite of acycloguanosine (P-ACG) and six antivirals was tested individually and in double and triple combinations on two strains of the herpes simplex virus (HSV) type 1 (sensitive to acyclovir and resistant to acyclovir) using the CPE inhibition method in the Vero E6 cell microcultures. These are: phosphite of acycloguanosine (P-ACG), Ara-A, cidofovir (CDV), ribavirin (Rib), phosphonoformate (PFA), glycyrrhizic acid (GLN) and alpha-interferon (alpha-IFN). All studied double combinations and triple combinations including P-ACV inhibited replication of both HSV strains more effectively than any drug alone. Various types of interactions depending on the virus type were observed in both viral models: synergistic (double combinations P-ACG with PFA, CDV, Rib, alpha-IFN and triple combinations P-ACG with alpha-IFN +PFA, alpha-IFN +AraA, alpha-IFN +CDV, PFA+CDV, PFA+Rib, CDV+AraA, CDV+Rib, CDV+GLN,PFA+AraA) and additive (P-ACG with AraA and PFA+GLN). Neither antagonism nor interference was noted for any combinations. Adduced results suggest that these combinations might be clinically useful for the treatment of certain herpes simplex virus type 1 infections. |
| format | Article |
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These are: phosphite of acycloguanosine (P-ACG), Ara-A, cidofovir (CDV), ribavirin (Rib), phosphonoformate (PFA), glycyrrhizic acid (GLN) and alpha-interferon (alpha-IFN). All studied double combinations and triple combinations including P-ACV inhibited replication of both HSV strains more effectively than any drug alone. Various types of interactions depending on the virus type were observed in both viral models: synergistic (double combinations P-ACG with PFA, CDV, Rib, alpha-IFN and triple combinations P-ACG with alpha-IFN +PFA, alpha-IFN +AraA, alpha-IFN +CDV, PFA+CDV, PFA+Rib, CDV+AraA, CDV+Rib, CDV+GLN,PFA+AraA) and additive (P-ACG with AraA and PFA+GLN). Neither antagonism nor interference was noted for any combinations. Adduced results suggest that these combinations might be clinically useful for the treatment of certain herpes simplex virus type 1 infections.</description><identifier>ISSN: 0507-4088</identifier><identifier>PMID: 25929034</identifier><language>rus</language><publisher>Russia (Federation)</publisher><subject>Acyclovir - pharmacology ; Animals ; Antiviral Agents - pharmacology ; Cercopithecus aethiops ; Cytosine - analogs & derivatives ; Cytosine - pharmacology ; Drug Resistance, Viral - physiology ; Drug Synergism ; Drug Therapy, Combination ; Foscarnet - pharmacology ; Glycyrrhizic Acid - pharmacology ; Herpesvirus 1, Human - drug effects ; Herpesvirus 1, Human - physiology ; Humans ; Interferon-alpha - pharmacology ; Organophosphonates - pharmacology ; Phosphites ; Ribavirin - pharmacology ; Vero Cells ; Vidarabine - pharmacology ; Virus Replication - drug effects</subject><ispartof>Voprosy virusologiĭ, 2014, Vol.59 (6), p.32-35</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25929034$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Andronova, V L</creatorcontrib><creatorcontrib>Jasko, M V</creatorcontrib><creatorcontrib>Kukhanova, M K</creatorcontrib><creatorcontrib>Skoblov, Yu S</creatorcontrib><creatorcontrib>Deryabin, P G</creatorcontrib><creatorcontrib>Galegov, G A</creatorcontrib><title>Research of suppression of the herpes simplex virus reproduction with drug resistance by combination phosphite of acycloguanosine with some antiherpetic drugs</title><title>Voprosy virusologiĭ</title><addtitle>Vopr Virusol</addtitle><description>The activity of the phosphite of acycloguanosine (P-ACG) and six antivirals was tested individually and in double and triple combinations on two strains of the herpes simplex virus (HSV) type 1 (sensitive to acyclovir and resistant to acyclovir) using the CPE inhibition method in the Vero E6 cell microcultures. These are: phosphite of acycloguanosine (P-ACG), Ara-A, cidofovir (CDV), ribavirin (Rib), phosphonoformate (PFA), glycyrrhizic acid (GLN) and alpha-interferon (alpha-IFN). All studied double combinations and triple combinations including P-ACV inhibited replication of both HSV strains more effectively than any drug alone. Various types of interactions depending on the virus type were observed in both viral models: synergistic (double combinations P-ACG with PFA, CDV, Rib, alpha-IFN and triple combinations P-ACG with alpha-IFN +PFA, alpha-IFN +AraA, alpha-IFN +CDV, PFA+CDV, PFA+Rib, CDV+AraA, CDV+Rib, CDV+GLN,PFA+AraA) and additive (P-ACG with AraA and PFA+GLN). Neither antagonism nor interference was noted for any combinations. Adduced results suggest that these combinations might be clinically useful for the treatment of certain herpes simplex virus type 1 infections.</description><subject>Acyclovir - pharmacology</subject><subject>Animals</subject><subject>Antiviral Agents - pharmacology</subject><subject>Cercopithecus aethiops</subject><subject>Cytosine - analogs & derivatives</subject><subject>Cytosine - pharmacology</subject><subject>Drug Resistance, Viral - physiology</subject><subject>Drug Synergism</subject><subject>Drug Therapy, Combination</subject><subject>Foscarnet - pharmacology</subject><subject>Glycyrrhizic Acid - pharmacology</subject><subject>Herpesvirus 1, Human - drug effects</subject><subject>Herpesvirus 1, Human - physiology</subject><subject>Humans</subject><subject>Interferon-alpha - pharmacology</subject><subject>Organophosphonates - pharmacology</subject><subject>Phosphites</subject><subject>Ribavirin - pharmacology</subject><subject>Vero Cells</subject><subject>Vidarabine - pharmacology</subject><subject>Virus Replication - drug effects</subject><issn>0507-4088</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtOwzAQRbMA0VL4BeQlm0hOHDv2ElW8pEpICNaR7U4boyQ2Hgfoz_CtpA9WoxkdndG9Z9mcclrnFZVyll0iflBacanqi2xWclUqyqp59vsKCDralvgNwTGECIjOD_s1tUBaiAGQoOtDBz_ky8URSYQQ_Xq0aQ9-u9SSdRy30xkdJj1YIGZHrO-NG_SBCa3H0LoEe622O9v57agHj26AowB9D0QPyR0eJmcPSrzKzje6Q7g-zUX2_nD_tnzKVy-Pz8u7VR6KUqRciIJNcZiBggGvOAhT1JKCYNJIKmRtFXBhZblh1nDFTKkYMGVoxZQ2TLJFdnv0TsE-R8DU9A4tdJ0ewI_YFKKupWKs4BN6c0JH08O6CdH1Ou6a_07ZH0r0dhg</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Andronova, V L</creator><creator>Jasko, M V</creator><creator>Kukhanova, M K</creator><creator>Skoblov, Yu S</creator><creator>Deryabin, P G</creator><creator>Galegov, G A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Research of suppression of the herpes simplex virus reproduction with drug resistance by combination phosphite of acycloguanosine with some antiherpetic drugs</title><author>Andronova, V L ; Jasko, M V ; Kukhanova, M K ; Skoblov, Yu S ; Deryabin, P G ; Galegov, G A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-66130343be13e545e6b1780e638b80687c9e56c82f3cb593b293e39b0439ab383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>rus</language><creationdate>2014</creationdate><topic>Acyclovir - pharmacology</topic><topic>Animals</topic><topic>Antiviral Agents - pharmacology</topic><topic>Cercopithecus aethiops</topic><topic>Cytosine - analogs & derivatives</topic><topic>Cytosine - pharmacology</topic><topic>Drug Resistance, Viral - physiology</topic><topic>Drug Synergism</topic><topic>Drug Therapy, Combination</topic><topic>Foscarnet - pharmacology</topic><topic>Glycyrrhizic Acid - pharmacology</topic><topic>Herpesvirus 1, Human - drug effects</topic><topic>Herpesvirus 1, Human - physiology</topic><topic>Humans</topic><topic>Interferon-alpha - pharmacology</topic><topic>Organophosphonates - pharmacology</topic><topic>Phosphites</topic><topic>Ribavirin - pharmacology</topic><topic>Vero Cells</topic><topic>Vidarabine - pharmacology</topic><topic>Virus Replication - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Andronova, V L</creatorcontrib><creatorcontrib>Jasko, M V</creatorcontrib><creatorcontrib>Kukhanova, M K</creatorcontrib><creatorcontrib>Skoblov, Yu S</creatorcontrib><creatorcontrib>Deryabin, P G</creatorcontrib><creatorcontrib>Galegov, G A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Voprosy virusologiĭ</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Andronova, V L</au><au>Jasko, M V</au><au>Kukhanova, M K</au><au>Skoblov, Yu S</au><au>Deryabin, P G</au><au>Galegov, G A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Research of suppression of the herpes simplex virus reproduction with drug resistance by combination phosphite of acycloguanosine with some antiherpetic drugs</atitle><jtitle>Voprosy virusologiĭ</jtitle><addtitle>Vopr Virusol</addtitle><date>2014</date><risdate>2014</risdate><volume>59</volume><issue>6</issue><spage>32</spage><epage>35</epage><pages>32-35</pages><issn>0507-4088</issn><abstract>The activity of the phosphite of acycloguanosine (P-ACG) and six antivirals was tested individually and in double and triple combinations on two strains of the herpes simplex virus (HSV) type 1 (sensitive to acyclovir and resistant to acyclovir) using the CPE inhibition method in the Vero E6 cell microcultures. These are: phosphite of acycloguanosine (P-ACG), Ara-A, cidofovir (CDV), ribavirin (Rib), phosphonoformate (PFA), glycyrrhizic acid (GLN) and alpha-interferon (alpha-IFN). All studied double combinations and triple combinations including P-ACV inhibited replication of both HSV strains more effectively than any drug alone. Various types of interactions depending on the virus type were observed in both viral models: synergistic (double combinations P-ACG with PFA, CDV, Rib, alpha-IFN and triple combinations P-ACG with alpha-IFN +PFA, alpha-IFN +AraA, alpha-IFN +CDV, PFA+CDV, PFA+Rib, CDV+AraA, CDV+Rib, CDV+GLN,PFA+AraA) and additive (P-ACG with AraA and PFA+GLN). Neither antagonism nor interference was noted for any combinations. Adduced results suggest that these combinations might be clinically useful for the treatment of certain herpes simplex virus type 1 infections.</abstract><cop>Russia (Federation)</cop><pmid>25929034</pmid><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Acyclovir - pharmacology Animals Antiviral Agents - pharmacology Cercopithecus aethiops Cytosine - analogs & derivatives Cytosine - pharmacology Drug Resistance, Viral - physiology Drug Synergism Drug Therapy, Combination Foscarnet - pharmacology Glycyrrhizic Acid - pharmacology Herpesvirus 1, Human - drug effects Herpesvirus 1, Human - physiology Humans Interferon-alpha - pharmacology Organophosphonates - pharmacology Phosphites Ribavirin - pharmacology Vero Cells Vidarabine - pharmacology Virus Replication - drug effects |
| title | Research of suppression of the herpes simplex virus reproduction with drug resistance by combination phosphite of acycloguanosine with some antiherpetic drugs |
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