Radical Cyclization of Epoxy Vinyl- and Allylsulfones Promoted by Titanocene Chloride
A titanocene-mediated intramolecular radical addition of different epoxy vinyl- and allylsulfones has been achieved. Five- and six-membered ring products were obtained in good to excellent yields in the presence of both 2.2 and 0.2 equiv of Cp2TiCl. A novel double-activation strategy allowed us to a...
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| Veröffentlicht in: | Journal of organic chemistry 2015-05, Vol.80 (9), p.4378-4391 |
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| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | A titanocene-mediated intramolecular radical addition of different epoxy vinyl- and allylsulfones has been achieved. Five- and six-membered ring products were obtained in good to excellent yields in the presence of both 2.2 and 0.2 equiv of Cp2TiCl. A novel double-activation strategy allowed us to achieve small-size rings such as cyclobutanes and cyclopropanes. |
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| ISSN: | 0022-3263 1520-6904 |
| DOI: | 10.1021/acs.joc.5b00206 |