Different vitamin D receptor agonists exhibit differential effects on endothelial function and aortic gene expression in 5/6 nephrectomized rats

[Display omitted] •Alfacalcidol, paricalcitol and VS-105 exhibit similar efficacy in suppressing PTH.•Yet these vitamin D analogs exhibit different effects on endothelial function.•Effect on endothelial function is independent of their effects on PTH and calcium.•Uremia impacts the expression of num...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2015-04, Vol.148, p.202-209
Hauptverfasser:	Wu-Wong, J. Ruth, Li, Xinmin, Chen, Yung-wu
Format:	Artikel
Sprache:	eng
Schlagworte:	Alfacalcidol Animals Aorta - drug effects Aorta - metabolism Aortic gene expression Calcitriol - pharmacology Endothelial function Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Kidney - drug effects Kidney - metabolism Kidney - surgery Kidney disease Nephrectomy Paricalcitol Rats Receptors, Calcitriol - agonists Vitamin D analogs Vitamin D receptor Vitamins - pharmacology VS-105
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