Expression levels of SF3B3 correlate with prognosis and endocrine resistance in estrogen receptor-positive breast cancer

De novo or acquired resistance to endocrine therapy limits its utility in a significant number of estrogen receptor-positive (ER-positive) breast cancers. It is crucial to identify novel targets for therapeutic intervention and improve the success of endocrine therapies. Splicing factor 3b, subunit...

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Veröffentlicht in:	Modern pathology 2015-05, Vol.28 (5), p.677-685
Hauptverfasser:	Gökmen-Polar, Yesim, Neelamraju, Yaseswini, Goswami, Chirayu P, Gu, Xiaoping, Nallamothu, Gouthami, Janga, Sarath Chandra, Badve, Sunil
Format:	Artikel
Sprache:	eng
Schlagworte:	38/39 692/53/2421 Antineoplastic Agents, Hormonal - therapeutic use Biomarkers, Tumor - analysis Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Clinical trials Datasets Drug Resistance, Neoplasm - physiology Endocrine therapy Estrogen Receptor alpha - biosynthesis Estrogens Female Gene expression Genomes Humans Informatics Kaplan-Meier Estimate Laboratory Medicine Medical prognosis Medicine Medicine & Public Health Melanoma Mutation Neoplasm Recurrence, Local - metabolism Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology original-article Pathology Polymerase Chain Reaction Prognosis RNA Splicing Factors RNA-Binding Proteins - biosynthesis Transcriptome Tumors Up-Regulation
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