Liver innervation and hepatic function: new insights
Abstract The hepatic nervous system has a well-known impact on the regulation of liver function and organism homeostasis. The aim of this review is to summarize the new available data regarding the role of hepatic nerves. In the last decade, studies have shown that hepatic nerves exert subtle but si...
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Veröffentlicht in: | The Journal of surgical research 2015-04, Vol.194 (2), p.511-519 |
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container_title | The Journal of surgical research |
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creator | Kandilis, Apostolos N., MD Papadopoulou, Iliana P., MD Koskinas, John, MD Sotiropoulos, George, MD Tiniakos, Dina G., MD |
description | Abstract The hepatic nervous system has a well-known impact on the regulation of liver function and organism homeostasis. The aim of this review is to summarize the new available data regarding the role of hepatic nerves. In the last decade, studies have shown that hepatic nerves exert subtle but significant modifications on the regulation of glucose and lipid metabolism, food intake, and liver regeneration. They also play a role in liver disease pathogenesis, and hepatic denervation has beneficial results to liver graft ischemia–reperfusion injury. Available data are still limited, and further research toward neural pathways involving the liver that can modify response to disease is required. |
doi_str_mv | 10.1016/j.jss.2014.12.006 |
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The aim of this review is to summarize the new available data regarding the role of hepatic nerves. In the last decade, studies have shown that hepatic nerves exert subtle but significant modifications on the regulation of glucose and lipid metabolism, food intake, and liver regeneration. They also play a role in liver disease pathogenesis, and hepatic denervation has beneficial results to liver graft ischemia–reperfusion injury. 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Available data are still limited, and further research toward neural pathways involving the liver that can modify response to disease is required.</description><subject>Animals</subject><subject>Hepatic innervation</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Liver - innervation</subject><subject>Liver - physiology</subject><subject>Liver regeneration</subject><subject>Liver repair</subject><subject>Metabolism</subject><subject>Surgery</subject><subject>Transplanted liver</subject><issn>0022-4804</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAQhS0EokvhB_RS5cglYcZ24qRISFVVWqSVOABny3EmrdOss9jJVv33ONqWAwd8sZ_13pPmG8bOEAoErD4NxRBjwQFlgbwAqF6xDUJT5nWlxGu2AeA8lzXIE_YuxgGSbpR4y054mY4EuWFy6w4UMuc9hYOZ3eQz47vsnvZJ2KxfvF0_LzJPj8kV3d39HN-zN70ZI314vk_Zr6_XP69u8-33m29Xl9vcSqjn3FghqVYNdRK6VqiqLVtUXKmeSkyPngvZVK1qjUVKUqC1Qpm-Ryx7DlKcso_H3n2Yfi8UZ71z0dI4Gk_TEjVWStV1I6oqWfFotWGKMVCv98HtTHjSCHqFpQedYOkVlkauE6yUOX-uX9oddX8TL3SS4fPRQGnIg6Ogo3XkLXUukJ11N7n_1n_5J21H55014wM9URymJfhET6OOKaB_rNtal4USEDlw8QdhTI3j</recordid><startdate>20150401</startdate><enddate>20150401</enddate><creator>Kandilis, Apostolos N., MD</creator><creator>Papadopoulou, Iliana P., MD</creator><creator>Koskinas, John, MD</creator><creator>Sotiropoulos, George, MD</creator><creator>Tiniakos, Dina G., MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20150401</creationdate><title>Liver innervation and hepatic function: new insights</title><author>Kandilis, Apostolos N., MD ; Papadopoulou, Iliana P., MD ; Koskinas, John, MD ; Sotiropoulos, George, MD ; Tiniakos, Dina G., MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-ac34e879ed40db376b5b17277fe51172f23496b7bac1e72f31cc37aff115f2043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Hepatic innervation</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Liver - innervation</topic><topic>Liver - physiology</topic><topic>Liver regeneration</topic><topic>Liver repair</topic><topic>Metabolism</topic><topic>Surgery</topic><topic>Transplanted liver</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kandilis, Apostolos N., MD</creatorcontrib><creatorcontrib>Papadopoulou, Iliana P., MD</creatorcontrib><creatorcontrib>Koskinas, John, MD</creatorcontrib><creatorcontrib>Sotiropoulos, George, MD</creatorcontrib><creatorcontrib>Tiniakos, Dina G., MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kandilis, Apostolos N., MD</au><au>Papadopoulou, Iliana P., MD</au><au>Koskinas, John, MD</au><au>Sotiropoulos, George, MD</au><au>Tiniakos, Dina G., MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Liver innervation and hepatic function: new insights</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>2015-04-01</date><risdate>2015</risdate><volume>194</volume><issue>2</issue><spage>511</spage><epage>519</epage><pages>511-519</pages><issn>0022-4804</issn><eissn>1095-8673</eissn><abstract>Abstract The hepatic nervous system has a well-known impact on the regulation of liver function and organism homeostasis. 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subjects | Animals Hepatic innervation Homeostasis Humans Liver - innervation Liver - physiology Liver regeneration Liver repair Metabolism Surgery Transplanted liver |
title | Liver innervation and hepatic function: new insights |
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