Liver innervation and hepatic function: new insights

Abstract The hepatic nervous system has a well-known impact on the regulation of liver function and organism homeostasis. The aim of this review is to summarize the new available data regarding the role of hepatic nerves. In the last decade, studies have shown that hepatic nerves exert subtle but si...

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Veröffentlicht in:The Journal of surgical research 2015-04, Vol.194 (2), p.511-519
Hauptverfasser: Kandilis, Apostolos N., MD, Papadopoulou, Iliana P., MD, Koskinas, John, MD, Sotiropoulos, George, MD, Tiniakos, Dina G., MD
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container_end_page 519
container_issue 2
container_start_page 511
container_title The Journal of surgical research
container_volume 194
creator Kandilis, Apostolos N., MD
Papadopoulou, Iliana P., MD
Koskinas, John, MD
Sotiropoulos, George, MD
Tiniakos, Dina G., MD
description Abstract The hepatic nervous system has a well-known impact on the regulation of liver function and organism homeostasis. The aim of this review is to summarize the new available data regarding the role of hepatic nerves. In the last decade, studies have shown that hepatic nerves exert subtle but significant modifications on the regulation of glucose and lipid metabolism, food intake, and liver regeneration. They also play a role in liver disease pathogenesis, and hepatic denervation has beneficial results to liver graft ischemia–reperfusion injury. Available data are still limited, and further research toward neural pathways involving the liver that can modify response to disease is required.
doi_str_mv 10.1016/j.jss.2014.12.006
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source MEDLINE; Elsevier ScienceDirect Journals
subjects Animals
Hepatic innervation
Homeostasis
Humans
Liver - innervation
Liver - physiology
Liver regeneration
Liver repair
Metabolism
Surgery
Transplanted liver
title Liver innervation and hepatic function: new insights
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