Analysis of the karyotype abnormalities and its prognostic in 298 patients with myelodysplastic syndrome

To investigate the relationship between cytogenetic markers with World Health Organization (WHO) classification, disease progress and prognosis in cases with primary myelodysplastic syndromes (MDS). 298 patients with de novo MDS from the first affiliated hospital of medical school, Zhejiang Universi...

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Veröffentlicht in:	Zhōnghuá xuèyèxué zázhì 2015-04, Vol.36 (4), p.297-301
Hauptverfasser:	Yan, Xuefen, Wei, Juying, Wang, Jinghan, Ren, Yanling, Zhou, Xinping, Mei, Chen, Ye, Li, Xie, Lili, Hu, Chao, Jin, Jie, Tong, Hongyan
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Sprache:	chi
Schlagworte:	Abnormal Karyotype Anemia, Refractory Chromosome Aberrations Chromosomes, Human, Pair 8 Follow-Up Studies Humans Karyotyping Myelodysplastic Syndromes Prognosis Retrospective Studies Risk Factors World Health Organization
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creator	Yan, Xuefen Wei, Juying Wang, Jinghan Ren, Yanling Zhou, Xinping Mei, Chen Ye, Li Xie, Lili Hu, Chao Jin, Jie Tong, Hongyan
description	To investigate the relationship between cytogenetic markers with World Health Organization (WHO) classification, disease progress and prognosis in cases with primary myelodysplastic syndromes (MDS). 298 patients with de novo MDS from the first affiliated hospital of medical school, Zhejiang University were enrolled in the retrospective analysis of WHO classification, karyotype, and prognosis. Follow-up study was also conducted. The WHO classifications at first diagnosis were as follows: refractory cytopenia with unilineage dysplasia (RCUD), 18 cases; refractory anemia with ring sideroblasts (RARS), 8 cases; refractory cytopenia with multiline dysplasia (RCMD), 104 cases; refractory anemia with excess blasts-1, 76 cases; refractory anemia with excess blasts-2, 85 cases; MDS unclassified (MDS-U), 5 cases involved; and single del (5q), 2 cases. 39.6% of MDS patients carried karyotypic abnormalities. Among them, the frequency of numerical abnormalities, structural abnormalities and the existence of composite abno
doi_str_mv	10.3760/cma.j.issn.0253-2727.2015.04.008
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subjects	Abnormal Karyotype Anemia, Refractory Chromosome Aberrations Chromosomes, Human, Pair 8 Follow-Up Studies Humans Karyotyping Myelodysplastic Syndromes Prognosis Retrospective Studies Risk Factors World Health Organization
title	Analysis of the karyotype abnormalities and its prognostic in 298 patients with myelodysplastic syndrome
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