The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis

Recently, there has been an increasing amount of literature published on the effects of 4-phenylbutyric acid (4-PBA) in various biological systems. 4-PBA is currently used clinically to treat urea cycle disorders under the trade name Buphenyl. Recent studies however have explored 4-PBA in the contex...

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Veröffentlicht in:	The international journal of biochemistry & cell biology 2015-04, Vol.61, p.45-52
Hauptverfasser:	Kolb, P.S., Ayaub, E.A., Zhou, W., Yum, V., Dickhout, J.G., Ask, K.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-PBA 4-Phenylbutyric acid Animals Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress - drug effects ER stress Homeostasis Humans Phenylbutyrates - pharmacology Phenylbutyrates - therapeutic use Signal Transduction Unfolded Protein Response - drug effects UPR Urea Cycle Disorders, Inborn - drug therapy
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