Natural Killer Cell Activating Receptor NKG2D Is Involved in the Immunosuppressive Effects of Mycophenolate Mofetil and Hepatitis B Virus Infection

Abstract The purpose of this study is to investigate whether mycophenolate mofetil (MMF), a new immunosuppressant, and its metabolite mycophenolic acid (MPA) affect the activity of liver resident natural killer (NK) cells, resulting in increased susceptibility to hepatitis B virus (HBv) infection. H...

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Veröffentlicht in:	The American journal of the medical sciences 2015-05, Vol.349 (5), p.432-437
Hauptverfasser:	Dong, Shuai, MD, Geng, Lei, MD, Shen, Miao-Da, MD, Zheng, Shu-Sen, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytotoxicity, Immunologic - drug effects Enzyme Inhibitors - pharmacology Hepatitis B - immunology Hepatitis B - pathology Hepatitis B virus Immunosuppressive Agents - pharmacology IMP Dehydrogenase - antagonists & inhibitors Interleukin-15 - immunology Internal Medicine Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Liver - pathology Lymphocyte Activation - drug effects Mice Mice, Inbred C57BL Mycophenolate mofetil Mycophenolic acid Mycophenolic Acid - analogs & derivatives Mycophenolic Acid - pharmacology NK Cell Lectin-Like Receptor Subfamily A - metabolism NK Cell Lectin-Like Receptor Subfamily C - metabolism NK Cell Lectin-Like Receptor Subfamily K - metabolism NK cells
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