Bilberry extract supplementation for preventing eye fatigue in video display terminal workers
OBJECTIVES: To examine the effect of a dietary supplement containing bilberry extract (BE) on eye fatigue induced by acute video display terminal (VDT) loads. DESIGN AND SETTING: A prospective, randomized, double-blind, placebo-controlled study was performed from August 2012 to February 2013 in the...
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| creator | Ozawa, Y Kawashima, M Inoue, S Inagaki, E Suzuki, A Ooe, E Kobayashi, S Tsubota, Kazuo |
| description | OBJECTIVES: To examine the effect of a dietary supplement containing bilberry extract (BE) on eye fatigue induced by acute video display terminal (VDT) loads. DESIGN AND SETTING: A prospective, randomized, double-blind, placebo-controlled study was performed from August 2012 to February 2013 in the Medical Corporation Jico-kai Yagi Hospital, and the Shinyokohama Shinoharaguchi Orthopedic Surgery and Dermatology Clinic, in Japan. PARTICIPANTS: Two hundred eighty-one office workers aged 20–40 years that used VDTs were screened by critical flicker fusion (CFF) and near point accommodation (NPA). INTERVENTION: The participants were randomized to either a BE (480 mg/day) or placebo (vehicle) group, and took allocated capsule, daily, for 8 weeks. MEASUREMENTS: The CFF, NPA, contrast visual acuity, functional visual acuity, keratoconjunctival epithelial damage, and fluorescein tear film break-up time were examined, and 18 subjective symptoms of eye fatigue were evaluated by questionnaire. Adverse events were reported via medical interviews. Data were collected both before and after VDT load at baseline, and 4, and 8 weeks after daily supplementation with either BE or placebo. RESULTS: Of 281 participants screened, 88 having relatively lower levels of CFF and NPA were enrolled in the study. Of these, 37 control and 43 BE group subjects completed the study. The VDT load-induced reduction in CFF was alleviated after 8 weeks of BE supplementation (95% confidence interval, 0.10–1.60; p=0.023), in contrast to placebo supplementation, while NPA variation was not. Of the subjective symptoms of eye fatigue, VDT load-induced ocular fatigue sensation, ocular pain, eye heaviness, uncomfortable sensation, and foreign body sensation were mitigated more in the BE group than in the control group, at week 8 (p |
| doi_str_mv | 10.1007/s12603-014-0573-6 |
| format | Article |
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DESIGN AND SETTING: A prospective, randomized, double-blind, placebo-controlled study was performed from August 2012 to February 2013 in the Medical Corporation Jico-kai Yagi Hospital, and the Shinyokohama Shinoharaguchi Orthopedic Surgery and Dermatology Clinic, in Japan. PARTICIPANTS: Two hundred eighty-one office workers aged 20–40 years that used VDTs were screened by critical flicker fusion (CFF) and near point accommodation (NPA). INTERVENTION: The participants were randomized to either a BE (480 mg/day) or placebo (vehicle) group, and took allocated capsule, daily, for 8 weeks. MEASUREMENTS: The CFF, NPA, contrast visual acuity, functional visual acuity, keratoconjunctival epithelial damage, and fluorescein tear film break-up time were examined, and 18 subjective symptoms of eye fatigue were evaluated by questionnaire. Adverse events were reported via medical interviews. Data were collected both before and after VDT load at baseline, and 4, and 8 weeks after daily supplementation with either BE or placebo. RESULTS: Of 281 participants screened, 88 having relatively lower levels of CFF and NPA were enrolled in the study. Of these, 37 control and 43 BE group subjects completed the study. The VDT load-induced reduction in CFF was alleviated after 8 weeks of BE supplementation (95% confidence interval, 0.10–1.60; p=0.023), in contrast to placebo supplementation, while NPA variation was not. Of the subjective symptoms of eye fatigue, VDT load-induced ocular fatigue sensation, ocular pain, eye heaviness, uncomfortable sensation, and foreign body sensation were mitigated more in the BE group than in the control group, at week 8 (p<0.05). There were no severe adverse events in either group. CONCLUSIONS: BE supplementation improved some of the objective and subjective parameters of eye fatigue induced by VDT loads.</description><identifier>ISSN: 1279-7707</identifier><identifier>EISSN: 1760-4788</identifier><identifier>DOI: 10.1007/s12603-014-0573-6</identifier><identifier>PMID: 25923485</identifier><language>eng</language><publisher>Paris: Springer Paris</publisher><subject>Adult ; Aging ; Asthenopia - diet therapy ; Asthenopia - pathology ; Asthenopia - physiopathology ; Asthenopia - prevention & control ; Bone surgery ; Clinical trials ; Computer Terminals ; confidence interval ; Conjunctiva - drug effects ; Conjunctiva - pathology ; Dermatology ; Dietary supplements ; Dietary Supplements - adverse effects ; Double-Blind Method ; Ethics ; eyes ; Female ; fluorescein ; Geriatrics/Gerontology ; Hospitals ; Humans ; interviews ; Japan ; Male ; Medicine ; Medicine & Public Health ; Neurosciences ; Nutrition ; Ophthalmology ; Orthopedics ; pain ; placebos ; Plant Extracts - adverse effects ; Plant Extracts - pharmacology ; Primary Care Medicine ; Quality of Life Research ; Questionnaires ; Review boards ; surgery ; Surveys and Questionnaires ; Tears ; Vaccinium myrtillus - chemistry ; Visual acuity ; Visual Acuity - drug effects ; Visual Acuity - physiology ; Young Adult</subject><ispartof>The Journal of nutrition, health & aging, 2015-05, Vol.19 (5), p.548-554</ispartof><rights>Serdi and Springer-Verlag France 2014</rights><rights>Serdi and Springer-Verlag France 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c575t-388eab525cb6c000a23926f390c31b5e5766689bf2d4356656b387d5064b7ce3</citedby><cites>FETCH-LOGICAL-c575t-388eab525cb6c000a23926f390c31b5e5766689bf2d4356656b387d5064b7ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12603-014-0573-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12603-014-0573-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25923485$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ozawa, Y</creatorcontrib><creatorcontrib>Kawashima, M</creatorcontrib><creatorcontrib>Inoue, S</creatorcontrib><creatorcontrib>Inagaki, E</creatorcontrib><creatorcontrib>Suzuki, A</creatorcontrib><creatorcontrib>Ooe, E</creatorcontrib><creatorcontrib>Kobayashi, S</creatorcontrib><creatorcontrib>Tsubota, Kazuo</creatorcontrib><title>Bilberry extract supplementation for preventing eye fatigue in video display terminal workers</title><title>The Journal of nutrition, health & aging</title><addtitle>J Nutr Health Aging</addtitle><addtitle>J Nutr Health Aging</addtitle><description>OBJECTIVES: To examine the effect of a dietary supplement containing bilberry extract (BE) on eye fatigue induced by acute video display terminal (VDT) loads. DESIGN AND SETTING: A prospective, randomized, double-blind, placebo-controlled study was performed from August 2012 to February 2013 in the Medical Corporation Jico-kai Yagi Hospital, and the Shinyokohama Shinoharaguchi Orthopedic Surgery and Dermatology Clinic, in Japan. PARTICIPANTS: Two hundred eighty-one office workers aged 20–40 years that used VDTs were screened by critical flicker fusion (CFF) and near point accommodation (NPA). INTERVENTION: The participants were randomized to either a BE (480 mg/day) or placebo (vehicle) group, and took allocated capsule, daily, for 8 weeks. MEASUREMENTS: The CFF, NPA, contrast visual acuity, functional visual acuity, keratoconjunctival epithelial damage, and fluorescein tear film break-up time were examined, and 18 subjective symptoms of eye fatigue were evaluated by questionnaire. Adverse events were reported via medical interviews. Data were collected both before and after VDT load at baseline, and 4, and 8 weeks after daily supplementation with either BE or placebo. RESULTS: Of 281 participants screened, 88 having relatively lower levels of CFF and NPA were enrolled in the study. Of these, 37 control and 43 BE group subjects completed the study. The VDT load-induced reduction in CFF was alleviated after 8 weeks of BE supplementation (95% confidence interval, 0.10–1.60; p=0.023), in contrast to placebo supplementation, while NPA variation was not. Of the subjective symptoms of eye fatigue, VDT load-induced ocular fatigue sensation, ocular pain, eye heaviness, uncomfortable sensation, and foreign body sensation were mitigated more in the BE group than in the control group, at week 8 (p<0.05). There were no severe adverse events in either group. CONCLUSIONS: BE supplementation improved some of the objective and subjective parameters of eye fatigue induced by VDT loads.</description><subject>Adult</subject><subject>Aging</subject><subject>Asthenopia - diet therapy</subject><subject>Asthenopia - pathology</subject><subject>Asthenopia - physiopathology</subject><subject>Asthenopia - prevention & control</subject><subject>Bone surgery</subject><subject>Clinical trials</subject><subject>Computer Terminals</subject><subject>confidence interval</subject><subject>Conjunctiva - drug effects</subject><subject>Conjunctiva - pathology</subject><subject>Dermatology</subject><subject>Dietary supplements</subject><subject>Dietary Supplements - adverse effects</subject><subject>Double-Blind Method</subject><subject>Ethics</subject><subject>eyes</subject><subject>Female</subject><subject>fluorescein</subject><subject>Geriatrics/Gerontology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>interviews</subject><subject>Japan</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosciences</subject><subject>Nutrition</subject><subject>Ophthalmology</subject><subject>Orthopedics</subject><subject>pain</subject><subject>placebos</subject><subject>Plant Extracts - 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diet therapy</topic><topic>Asthenopia - pathology</topic><topic>Asthenopia - physiopathology</topic><topic>Asthenopia - prevention & control</topic><topic>Bone surgery</topic><topic>Clinical trials</topic><topic>Computer Terminals</topic><topic>confidence interval</topic><topic>Conjunctiva - drug effects</topic><topic>Conjunctiva - pathology</topic><topic>Dermatology</topic><topic>Dietary supplements</topic><topic>Dietary Supplements - adverse effects</topic><topic>Double-Blind Method</topic><topic>Ethics</topic><topic>eyes</topic><topic>Female</topic><topic>fluorescein</topic><topic>Geriatrics/Gerontology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>interviews</topic><topic>Japan</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosciences</topic><topic>Nutrition</topic><topic>Ophthalmology</topic><topic>Orthopedics</topic><topic>pain</topic><topic>placebos</topic><topic>Plant Extracts - adverse effects</topic><topic>Plant Extracts - pharmacology</topic><topic>Primary Care Medicine</topic><topic>Quality of Life Research</topic><topic>Questionnaires</topic><topic>Review boards</topic><topic>surgery</topic><topic>Surveys and Questionnaires</topic><topic>Tears</topic><topic>Vaccinium myrtillus - chemistry</topic><topic>Visual acuity</topic><topic>Visual Acuity - drug effects</topic><topic>Visual Acuity - physiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ozawa, Y</creatorcontrib><creatorcontrib>Kawashima, M</creatorcontrib><creatorcontrib>Inoue, S</creatorcontrib><creatorcontrib>Inagaki, E</creatorcontrib><creatorcontrib>Suzuki, A</creatorcontrib><creatorcontrib>Ooe, E</creatorcontrib><creatorcontrib>Kobayashi, S</creatorcontrib><creatorcontrib>Tsubota, Kazuo</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition, health & aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ozawa, Y</au><au>Kawashima, M</au><au>Inoue, S</au><au>Inagaki, E</au><au>Suzuki, A</au><au>Ooe, E</au><au>Kobayashi, S</au><au>Tsubota, Kazuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bilberry extract supplementation for preventing eye fatigue in video display terminal workers</atitle><jtitle>The Journal of nutrition, health & aging</jtitle><stitle>J Nutr Health Aging</stitle><addtitle>J Nutr Health Aging</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>19</volume><issue>5</issue><spage>548</spage><epage>554</epage><pages>548-554</pages><issn>1279-7707</issn><eissn>1760-4788</eissn><abstract>OBJECTIVES: To examine the effect of a dietary supplement containing bilberry extract (BE) on eye fatigue induced by acute video display terminal (VDT) loads. DESIGN AND SETTING: A prospective, randomized, double-blind, placebo-controlled study was performed from August 2012 to February 2013 in the Medical Corporation Jico-kai Yagi Hospital, and the Shinyokohama Shinoharaguchi Orthopedic Surgery and Dermatology Clinic, in Japan. PARTICIPANTS: Two hundred eighty-one office workers aged 20–40 years that used VDTs were screened by critical flicker fusion (CFF) and near point accommodation (NPA). INTERVENTION: The participants were randomized to either a BE (480 mg/day) or placebo (vehicle) group, and took allocated capsule, daily, for 8 weeks. MEASUREMENTS: The CFF, NPA, contrast visual acuity, functional visual acuity, keratoconjunctival epithelial damage, and fluorescein tear film break-up time were examined, and 18 subjective symptoms of eye fatigue were evaluated by questionnaire. Adverse events were reported via medical interviews. Data were collected both before and after VDT load at baseline, and 4, and 8 weeks after daily supplementation with either BE or placebo. RESULTS: Of 281 participants screened, 88 having relatively lower levels of CFF and NPA were enrolled in the study. Of these, 37 control and 43 BE group subjects completed the study. The VDT load-induced reduction in CFF was alleviated after 8 weeks of BE supplementation (95% confidence interval, 0.10–1.60; p=0.023), in contrast to placebo supplementation, while NPA variation was not. Of the subjective symptoms of eye fatigue, VDT load-induced ocular fatigue sensation, ocular pain, eye heaviness, uncomfortable sensation, and foreign body sensation were mitigated more in the BE group than in the control group, at week 8 (p<0.05). There were no severe adverse events in either group. CONCLUSIONS: BE supplementation improved some of the objective and subjective parameters of eye fatigue induced by VDT loads.</abstract><cop>Paris</cop><pub>Springer Paris</pub><pmid>25923485</pmid><doi>10.1007/s12603-014-0573-6</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aging Asthenopia - diet therapy Asthenopia - pathology Asthenopia - physiopathology Asthenopia - prevention & control Bone surgery Clinical trials Computer Terminals confidence interval Conjunctiva - drug effects Conjunctiva - pathology Dermatology Dietary supplements Dietary Supplements - adverse effects Double-Blind Method Ethics eyes Female fluorescein Geriatrics/Gerontology Hospitals Humans interviews Japan Male Medicine Medicine & Public Health Neurosciences Nutrition Ophthalmology Orthopedics pain placebos Plant Extracts - adverse effects Plant Extracts - pharmacology Primary Care Medicine Quality of Life Research Questionnaires Review boards surgery Surveys and Questionnaires Tears Vaccinium myrtillus - chemistry Visual acuity Visual Acuity - drug effects Visual Acuity - physiology Young Adult |
| title | Bilberry extract supplementation for preventing eye fatigue in video display terminal workers |
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