Heat shock factor 1 in protein homeostasis and oncogenic signal integration

Heat shock factor 1 (HSF1) is a stress-inducible transcription factor and has been described as a multi-faceted modulator of tumorigenesis. Heat shock, accumulation of misfolded proteins, or malignant transformation promotes the activation and nuclear translocation of HSF1, where it binds to the pro...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2015-03, Vol.75 (6), p.907-912
Hauptverfasser:	Home, Trisha, Jensen, Roy A, Rao, Rekha
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogenesis DNA-Binding Proteins - physiology Heat Shock Transcription Factors Homeostasis Humans Protein Biosynthesis Proteins - metabolism Signal Transduction - physiology Transcription Factors - physiology Tumor Suppressor Protein p53 - physiology
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