PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1
The complete sequence of the pleiotropic drug resistance gene PDR5 from Saccharomyces cerevisiae is reported and analyzed. PDR5 encodes a 160-kDa protein with a predicted duplicated six membrane-span domain and a repeated putative ATP-binding domain. PDR5 shares this structural feature with the mamm...
Gespeichert in:
| Veröffentlicht in: | The Journal of biological chemistry 1994-01, Vol.269 (3), p.2206-2214 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2214 |
|---|---|
| container_issue | 3 |
| container_start_page | 2206 |
| container_title | The Journal of biological chemistry |
| container_volume | 269 |
| creator | Balzi, E Wang, M Leterme, S Dyck, L. van Goffeau, A |
| description | The complete sequence of the pleiotropic drug resistance gene PDR5 from Saccharomyces cerevisiae is reported and analyzed. PDR5 encodes a 160-kDa protein with a predicted duplicated six membrane-span domain and a repeated putative ATP-binding domain. PDR5 shares this structural feature with the mammalian multidrug resistance pumps as well as the functional capacity of conferring resistance to various inhibitors upon amplification (Leppert, G., McDevitt, R., Falco, S.C., Van Dyk, T.K., Ficke, M.B., and Golin, J. (1990) Genetics 125, 13-20). The yeast PDR5 is thus a new member of the ABC (ATP-binding cassette) protein superfamily. Mutations in another yeast pleiotropic drug resistance gene, PDR1, encoding a putative transcription regulator (Balzi, E., Chen, W., Ulaszewski, S., Capieaux, E., and Goffeau, A. (1987) J. Biol. Chem. 262, 16871-16879), increase markedly the mRNA levels of the PDR5 and STE6 genes. The multidrug resistance mutations pdr1-3 and pdr1-6 also lead to considerable overexpression of the PDR5 plasma membrane protein |
| doi_str_mv | 10.1016/s0021-9258(17)42155-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_16777637</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16777637</sourcerecordid><originalsourceid>FETCH-LOGICAL-c509t-b824ba1d23c24e0ce2a53781bd81cfa47c5afc9674d8e5340a20f8a6f47ad2f3</originalsourceid><addsrcrecordid>eNo9kF2L1DAUhoMo67j6B4SFICIKVvPZtJeyfsKC4q7gXThNk06kbcYkVebfm9phchPI-5z3hAehK0reUELrt4kQRquWyeYlVa8Eo1JW6h7aUdLwikv68z7anZGH6FFKv0g5oqUX6KJhrRBK7dD87f13-RoDnsMfO-KjhZTxtIzZ93EZcLTJpwyzsdiE2dkY_TzgHGFOhxCzjetzjmEcbY-7I857u6Um-kP2YS4NwzJCDhGXTfQxeuBgTPbJ6b5Edx8_3F1_rm6-fvpy_e6mMpK0ueoaJjqgPeOGCUuMZSC5amjXN9Q4EMpIcKatlegbK7kgwIhroHZCQc8cv0QvttpDDL8Xm7KefDJ2HGG2YUma1kqpmqsCyg00MaQUrdOH6CeIR02JXjXr29WhXh1qqvR_zXqduzotWLrJ9uepk9eSPz_lkAyMrigxPp0x3tai4aRgzzZs74f9Xx-t7nwweztpVreaa8ZIXaCnG-QgaBhi6flx28ryO9ryfygNmts</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16777637</pqid></control><display><type>article</type><title>PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Balzi, E ; Wang, M ; Leterme, S ; Dyck, L. van ; Goffeau, A</creator><creatorcontrib>Balzi, E ; Wang, M ; Leterme, S ; Dyck, L. van ; Goffeau, A</creatorcontrib><description>The complete sequence of the pleiotropic drug resistance gene PDR5 from Saccharomyces cerevisiae is reported and analyzed. PDR5 encodes a 160-kDa protein with a predicted duplicated six membrane-span domain and a repeated putative ATP-binding domain. PDR5 shares this structural feature with the mammalian multidrug resistance pumps as well as the functional capacity of conferring resistance to various inhibitors upon amplification (Leppert, G., McDevitt, R., Falco, S.C., Van Dyk, T.K., Ficke, M.B., and Golin, J. (1990) Genetics 125, 13-20). The yeast PDR5 is thus a new member of the ABC (ATP-binding cassette) protein superfamily. Mutations in another yeast pleiotropic drug resistance gene, PDR1, encoding a putative transcription regulator (Balzi, E., Chen, W., Ulaszewski, S., Capieaux, E., and Goffeau, A. (1987) J. Biol. Chem. 262, 16871-16879), increase markedly the mRNA levels of the PDR5 and STE6 genes. The multidrug resistance mutations pdr1-3 and pdr1-6 also lead to considerable overexpression of the PDR5 plasma membrane protein</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1016/s0021-9258(17)42155-7</identifier><identifier>PMID: 8294477</identifier><identifier>CODEN: JBCHA3</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Biochemistry and Molecular Biology</publisher><subject>ADENOSINE TRIPHOSPHATE ; ADENOSINTRIFOSFATO ; Amino Acid Sequence ; Analytical, structural and metabolic biochemistry ; Animals ; ATP-Binding Cassette Transporters ; Base Sequence ; Binding and carrier proteins ; Biological and medical sciences ; Carrier Proteins - biosynthesis ; Carrier Proteins - chemistry ; Carrier Proteins - genetics ; Cloning, Molecular ; DNA-Binding Proteins ; Drug Resistance, Microbial - genetics ; Fundamental and applied biological sciences. Psychology ; Fungal Proteins - biosynthesis ; Fungal Proteins - genetics ; GENE ; Gene Expression ; GENES ; Genes, Fungal ; Glycoproteins ; Humans ; MEDICAMENT ; MEDICAMENTOS ; Membrane Proteins - biosynthesis ; Membrane Proteins - chemistry ; Membrane Proteins - genetics ; Membrane Proteins - isolation & purification ; Molecular Sequence Data ; Molecular Weight ; MUTACION ; Mutagenesis ; MUTATION ; Protein Structure, Secondary ; Proteins ; RESISTANCE AUX PRODUITS CHIMIQUES ; RESISTENCIA QUIMICA ; Restriction Mapping ; RNA, Messenger - biosynthesis ; SACCHAROMYCES CEREVISIAE ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae Proteins ; SECUENCIA NUCLEICA ; Sequence Homology, Amino Acid ; SEQUENCE NUCLEIQUE ; Terminator Regions, Genetic ; Trans-Activators ; Transcription Factors - metabolism ; Transcription, Genetic</subject><ispartof>The Journal of biological chemistry, 1994-01, Vol.269 (3), p.2206-2214</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-b824ba1d23c24e0ce2a53781bd81cfa47c5afc9674d8e5340a20f8a6f47ad2f3</citedby><cites>FETCH-LOGICAL-c509t-b824ba1d23c24e0ce2a53781bd81cfa47c5afc9674d8e5340a20f8a6f47ad2f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3964830$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8294477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Balzi, E</creatorcontrib><creatorcontrib>Wang, M</creatorcontrib><creatorcontrib>Leterme, S</creatorcontrib><creatorcontrib>Dyck, L. van</creatorcontrib><creatorcontrib>Goffeau, A</creatorcontrib><title>PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1</title><title>The Journal of biological chemistry</title><addtitle>J Biol Chem</addtitle><description>The complete sequence of the pleiotropic drug resistance gene PDR5 from Saccharomyces cerevisiae is reported and analyzed. PDR5 encodes a 160-kDa protein with a predicted duplicated six membrane-span domain and a repeated putative ATP-binding domain. PDR5 shares this structural feature with the mammalian multidrug resistance pumps as well as the functional capacity of conferring resistance to various inhibitors upon amplification (Leppert, G., McDevitt, R., Falco, S.C., Van Dyk, T.K., Ficke, M.B., and Golin, J. (1990) Genetics 125, 13-20). The yeast PDR5 is thus a new member of the ABC (ATP-binding cassette) protein superfamily. Mutations in another yeast pleiotropic drug resistance gene, PDR1, encoding a putative transcription regulator (Balzi, E., Chen, W., Ulaszewski, S., Capieaux, E., and Goffeau, A. (1987) J. Biol. Chem. 262, 16871-16879), increase markedly the mRNA levels of the PDR5 and STE6 genes. The multidrug resistance mutations pdr1-3 and pdr1-6 also lead to considerable overexpression of the PDR5 plasma membrane protein</description><subject>ADENOSINE TRIPHOSPHATE</subject><subject>ADENOSINTRIFOSFATO</subject><subject>Amino Acid Sequence</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>ATP-Binding Cassette Transporters</subject><subject>Base Sequence</subject><subject>Binding and carrier proteins</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - biosynthesis</subject><subject>Carrier Proteins - chemistry</subject><subject>Carrier Proteins - genetics</subject><subject>Cloning, Molecular</subject><subject>DNA-Binding Proteins</subject><subject>Drug Resistance, Microbial - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fungal Proteins - biosynthesis</subject><subject>Fungal Proteins - genetics</subject><subject>GENE</subject><subject>Gene Expression</subject><subject>GENES</subject><subject>Genes, Fungal</subject><subject>Glycoproteins</subject><subject>Humans</subject><subject>MEDICAMENT</subject><subject>MEDICAMENTOS</subject><subject>Membrane Proteins - biosynthesis</subject><subject>Membrane Proteins - chemistry</subject><subject>Membrane Proteins - genetics</subject><subject>Membrane Proteins - isolation & purification</subject><subject>Molecular Sequence Data</subject><subject>Molecular Weight</subject><subject>MUTACION</subject><subject>Mutagenesis</subject><subject>MUTATION</subject><subject>Protein Structure, Secondary</subject><subject>Proteins</subject><subject>RESISTANCE AUX PRODUITS CHIMIQUES</subject><subject>RESISTENCIA QUIMICA</subject><subject>Restriction Mapping</subject><subject>RNA, Messenger - biosynthesis</subject><subject>SACCHAROMYCES CEREVISIAE</subject><subject>Saccharomyces cerevisiae - genetics</subject><subject>Saccharomyces cerevisiae - metabolism</subject><subject>Saccharomyces cerevisiae Proteins</subject><subject>SECUENCIA NUCLEICA</subject><subject>Sequence Homology, Amino Acid</subject><subject>SEQUENCE NUCLEIQUE</subject><subject>Terminator Regions, Genetic</subject><subject>Trans-Activators</subject><subject>Transcription Factors - metabolism</subject><subject>Transcription, Genetic</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF2L1DAUhoMo67j6B4SFICIKVvPZtJeyfsKC4q7gXThNk06kbcYkVebfm9phchPI-5z3hAehK0reUELrt4kQRquWyeYlVa8Eo1JW6h7aUdLwikv68z7anZGH6FFKv0g5oqUX6KJhrRBK7dD87f13-RoDnsMfO-KjhZTxtIzZ93EZcLTJpwyzsdiE2dkY_TzgHGFOhxCzjetzjmEcbY-7I857u6Um-kP2YS4NwzJCDhGXTfQxeuBgTPbJ6b5Edx8_3F1_rm6-fvpy_e6mMpK0ueoaJjqgPeOGCUuMZSC5amjXN9Q4EMpIcKatlegbK7kgwIhroHZCQc8cv0QvttpDDL8Xm7KefDJ2HGG2YUma1kqpmqsCyg00MaQUrdOH6CeIR02JXjXr29WhXh1qqvR_zXqduzotWLrJ9uepk9eSPz_lkAyMrigxPp0x3tai4aRgzzZs74f9Xx-t7nwweztpVreaa8ZIXaCnG-QgaBhi6flx28ryO9ryfygNmts</recordid><startdate>19940121</startdate><enddate>19940121</enddate><creator>Balzi, E</creator><creator>Wang, M</creator><creator>Leterme, S</creator><creator>Dyck, L. van</creator><creator>Goffeau, A</creator><general>American Society for Biochemistry and Molecular Biology</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>19940121</creationdate><title>PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1</title><author>Balzi, E ; Wang, M ; Leterme, S ; Dyck, L. van ; Goffeau, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-b824ba1d23c24e0ce2a53781bd81cfa47c5afc9674d8e5340a20f8a6f47ad2f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>ADENOSINE TRIPHOSPHATE</topic><topic>ADENOSINTRIFOSFATO</topic><topic>Amino Acid Sequence</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>ATP-Binding Cassette Transporters</topic><topic>Base Sequence</topic><topic>Binding and carrier proteins</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - biosynthesis</topic><topic>Carrier Proteins - chemistry</topic><topic>Carrier Proteins - genetics</topic><topic>Cloning, Molecular</topic><topic>DNA-Binding Proteins</topic><topic>Drug Resistance, Microbial - genetics</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fungal Proteins - biosynthesis</topic><topic>Fungal Proteins - genetics</topic><topic>GENE</topic><topic>Gene Expression</topic><topic>GENES</topic><topic>Genes, Fungal</topic><topic>Glycoproteins</topic><topic>Humans</topic><topic>MEDICAMENT</topic><topic>MEDICAMENTOS</topic><topic>Membrane Proteins - biosynthesis</topic><topic>Membrane Proteins - chemistry</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - isolation & purification</topic><topic>Molecular Sequence Data</topic><topic>Molecular Weight</topic><topic>MUTACION</topic><topic>Mutagenesis</topic><topic>MUTATION</topic><topic>Protein Structure, Secondary</topic><topic>Proteins</topic><topic>RESISTANCE AUX PRODUITS CHIMIQUES</topic><topic>RESISTENCIA QUIMICA</topic><topic>Restriction Mapping</topic><topic>RNA, Messenger - biosynthesis</topic><topic>SACCHAROMYCES CEREVISIAE</topic><topic>Saccharomyces cerevisiae - genetics</topic><topic>Saccharomyces cerevisiae - metabolism</topic><topic>Saccharomyces cerevisiae Proteins</topic><topic>SECUENCIA NUCLEICA</topic><topic>Sequence Homology, Amino Acid</topic><topic>SEQUENCE NUCLEIQUE</topic><topic>Terminator Regions, Genetic</topic><topic>Trans-Activators</topic><topic>Transcription Factors - metabolism</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Balzi, E</creatorcontrib><creatorcontrib>Wang, M</creatorcontrib><creatorcontrib>Leterme, S</creatorcontrib><creatorcontrib>Dyck, L. van</creatorcontrib><creatorcontrib>Goffeau, A</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Balzi, E</au><au>Wang, M</au><au>Leterme, S</au><au>Dyck, L. van</au><au>Goffeau, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1994-01-21</date><risdate>1994</risdate><volume>269</volume><issue>3</issue><spage>2206</spage><epage>2214</epage><pages>2206-2214</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><coden>JBCHA3</coden><abstract>The complete sequence of the pleiotropic drug resistance gene PDR5 from Saccharomyces cerevisiae is reported and analyzed. PDR5 encodes a 160-kDa protein with a predicted duplicated six membrane-span domain and a repeated putative ATP-binding domain. PDR5 shares this structural feature with the mammalian multidrug resistance pumps as well as the functional capacity of conferring resistance to various inhibitors upon amplification (Leppert, G., McDevitt, R., Falco, S.C., Van Dyk, T.K., Ficke, M.B., and Golin, J. (1990) Genetics 125, 13-20). The yeast PDR5 is thus a new member of the ABC (ATP-binding cassette) protein superfamily. Mutations in another yeast pleiotropic drug resistance gene, PDR1, encoding a putative transcription regulator (Balzi, E., Chen, W., Ulaszewski, S., Capieaux, E., and Goffeau, A. (1987) J. Biol. Chem. 262, 16871-16879), increase markedly the mRNA levels of the PDR5 and STE6 genes. The multidrug resistance mutations pdr1-3 and pdr1-6 also lead to considerable overexpression of the PDR5 plasma membrane protein</abstract><cop>Bethesda, MD</cop><pub>American Society for Biochemistry and Molecular Biology</pub><pmid>8294477</pmid><doi>10.1016/s0021-9258(17)42155-7</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9258 |
| ispartof | The Journal of biological chemistry, 1994-01, Vol.269 (3), p.2206-2214 |
| issn | 0021-9258 1083-351X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16777637 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | ADENOSINE TRIPHOSPHATE ADENOSINTRIFOSFATO Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals ATP-Binding Cassette Transporters Base Sequence Binding and carrier proteins Biological and medical sciences Carrier Proteins - biosynthesis Carrier Proteins - chemistry Carrier Proteins - genetics Cloning, Molecular DNA-Binding Proteins Drug Resistance, Microbial - genetics Fundamental and applied biological sciences. Psychology Fungal Proteins - biosynthesis Fungal Proteins - genetics GENE Gene Expression GENES Genes, Fungal Glycoproteins Humans MEDICAMENT MEDICAMENTOS Membrane Proteins - biosynthesis Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - isolation & purification Molecular Sequence Data Molecular Weight MUTACION Mutagenesis MUTATION Protein Structure, Secondary Proteins RESISTANCE AUX PRODUITS CHIMIQUES RESISTENCIA QUIMICA Restriction Mapping RNA, Messenger - biosynthesis SACCHAROMYCES CEREVISIAE Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins SECUENCIA NUCLEICA Sequence Homology, Amino Acid SEQUENCE NUCLEIQUE Terminator Regions, Genetic Trans-Activators Transcription Factors - metabolism Transcription, Genetic |
| title | PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T11%3A54%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PDR5,%20a%20novel%20yeast%20multidrug%20resistance%20conferring%20transporter%20controlled%20by%20the%20transcription%20regulator%20PDR1&rft.jtitle=The%20Journal%20of%20biological%20chemistry&rft.au=Balzi,%20E&rft.date=1994-01-21&rft.volume=269&rft.issue=3&rft.spage=2206&rft.epage=2214&rft.pages=2206-2214&rft.issn=0021-9258&rft.eissn=1083-351X&rft.coden=JBCHA3&rft_id=info:doi/10.1016/s0021-9258(17)42155-7&rft_dat=%3Cproquest_cross%3E16777637%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16777637&rft_id=info:pmid/8294477&rfr_iscdi=true |