Effects of vinblastine and colchicine on male rat meiosis in vivo: Disturbances in spindle dynamics causing micronuclei and metaphase arrest

We have studied the effects of vinblastine sulfate (VBL) and colchicine (COL) on male rat in vivo and in vitro meiosis. A novel methodology based on isolating a segment of seminiferous tubules containing meiotically dividing spermatocytes was applied. During meiotic divisions at stage XIV of rat spe...

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Veröffentlicht in:	Environmental and molecular mutagenesis 1995, Vol.25 (2), p.106-117
Hauptverfasser:	Kallio, Marko, Sjöblom, Tiina, Lähdetie, Jaana
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals colchicine Colchicine - toxicity FISH In Situ Hybridization, Fluorescence Male Meiosis - drug effects meiotic spindle Micronucleus Tests Mitosis - drug effects Mutagens - toxicity Rats Rats, Sprague-Dawley spermatid micronuclei Spermatids - drug effects Spermatogenesis - drug effects Spindle Apparatus - drug effects vinblastine Vinblastine - toxicity
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