Maternal serum CA 125 levels in pregnancies with chromosomally-normal and -abnormal fetuses
We measured the maternal serum cancer antigen 125 (MS‐CA 125) levels in 98 nonpregnant women, 765 first‐ and second‐trimester pregnancies with chromosomally‐normal fetuses, and 54 chromosomally‐abnormal pregnancies. To determine the MS‐CA 125 concentration, we used a new automated microparticle enzy...
Gespeichert in:
| Veröffentlicht in: | Prenatal diagnosis 1993-12, Vol.13 (12), p.1123-1131 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1131 |
|---|---|
| container_issue | 12 |
| container_start_page | 1123 |
| container_title | Prenatal diagnosis |
| container_volume | 13 |
| creator | Van Lith, J. M. M. Mantingh, A. De Bruijn, H. W. A. |
| description | We measured the maternal serum cancer antigen 125 (MS‐CA 125) levels in 98 nonpregnant women, 765 first‐ and second‐trimester pregnancies with chromosomally‐normal fetuses, and 54 chromosomally‐abnormal pregnancies. To determine the MS‐CA 125 concentration, we used a new automated microparticle enzyme immunoassay with low inter‐assay variability. The median MS‐CA 125 level decreased from the first to the second trimester of pregnancy and was higher than that in non‐pregnant women. We found no difference between normal and Down's syndrome (n = 29) pregnancies ( t‐test: t = 0·57, p >0·5). The MS‐CA 125 levels in pregnancies with other chromosomal abnormalities showed no difference either, compared with the normals. We conclude that MS‐CA 125 is not a useful marker for fetal Down's syndrome, nor for other chromosomal disorders in pregnancy. |
| doi_str_mv | 10.1002/pd.1970131207 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_16773948</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>16773948</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2967-da6ff919119ee7d4a723ec3f0bcf3e33012ec559661c7a973aecce50e477db2a3</originalsourceid><addsrcrecordid>eNp9kElP3EAQhVsRSBmWY-59iLgZehm73UcyYWcAkQWkHFo17XIwaS90eSDz7zGa0US5cKoq1fdelR5jn6TYl0Kog67Yl9YIqaUS5gMbSWFNIpTSG2wkhk2i81R-ZFtEjwOeK2tG7NcUeowNBE4Y5zWfHHKpUh7wGQPxquFdxN8NNL5C4i9V_8D9Q2zrltoaQlgkTRuHhkNT8ARmq6nEfk5IO2yzhEC4u6rb7Mfx0ffJaXJ5fXI2ObxMvLKZSQrIytJKK6VFNMUYjNLodSlmvtSotZAKfZraLJPegDUa0HtMBY6NKWYK9DbbW_p2sX2aI_WurshjCNBgOycnM2O0HecDmCxBH1uiiKXrYlVDXDgp3FuErivcvwgH_vPKGMhDKONbDrQW6TyzqRQDZpbYSxVw8b6nu_n634HVQxX1-HethPjHZUab1N1dnbiL2y8_7_PpN3euXwFM35CR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>16773948</pqid></control><display><type>article</type><title>Maternal serum CA 125 levels in pregnancies with chromosomally-normal and -abnormal fetuses</title><source>Access via Wiley Online Library</source><creator>Van Lith, J. M. M. ; Mantingh, A. ; De Bruijn, H. W. A.</creator><creatorcontrib>Van Lith, J. M. M. ; Mantingh, A. ; De Bruijn, H. W. A. ; For the Dutch Working Party on Prenatal Diagnosis</creatorcontrib><description>We measured the maternal serum cancer antigen 125 (MS‐CA 125) levels in 98 nonpregnant women, 765 first‐ and second‐trimester pregnancies with chromosomally‐normal fetuses, and 54 chromosomally‐abnormal pregnancies. To determine the MS‐CA 125 concentration, we used a new automated microparticle enzyme immunoassay with low inter‐assay variability. The median MS‐CA 125 level decreased from the first to the second trimester of pregnancy and was higher than that in non‐pregnant women. We found no difference between normal and Down's syndrome (n = 29) pregnancies ( t‐test: t = 0·57, p >0·5). The MS‐CA 125 levels in pregnancies with other chromosomal abnormalities showed no difference either, compared with the normals. We conclude that MS‐CA 125 is not a useful marker for fetal Down's syndrome, nor for other chromosomal disorders in pregnancy.</description><identifier>ISSN: 0197-3851</identifier><identifier>EISSN: 1097-0223</identifier><identifier>DOI: 10.1002/pd.1970131207</identifier><identifier>CODEN: PRDIDM</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Biological and medical sciences ; CA 125 ; CA 125 antigen ; Down's syndrome ; Fetal chromosomal disorder ; First-trimester screening ; Gynecology. Andrology. Obstetrics ; man ; Management. Prenatal diagnosis ; Medical sciences ; Pregnancy. Fetus. Placenta ; prenatal diagnosis</subject><ispartof>Prenatal diagnosis, 1993-12, Vol.13 (12), p.1123-1131</ispartof><rights>Copyright © 1993 John Wiley & Sons, Ltd.</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2967-da6ff919119ee7d4a723ec3f0bcf3e33012ec559661c7a973aecce50e477db2a3</citedby><cites>FETCH-LOGICAL-c2967-da6ff919119ee7d4a723ec3f0bcf3e33012ec559661c7a973aecce50e477db2a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fpd.1970131207$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fpd.1970131207$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3869510$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Lith, J. M. M.</creatorcontrib><creatorcontrib>Mantingh, A.</creatorcontrib><creatorcontrib>De Bruijn, H. W. A.</creatorcontrib><creatorcontrib>For the Dutch Working Party on Prenatal Diagnosis</creatorcontrib><title>Maternal serum CA 125 levels in pregnancies with chromosomally-normal and -abnormal fetuses</title><title>Prenatal diagnosis</title><addtitle>Prenat. Diagn</addtitle><description>We measured the maternal serum cancer antigen 125 (MS‐CA 125) levels in 98 nonpregnant women, 765 first‐ and second‐trimester pregnancies with chromosomally‐normal fetuses, and 54 chromosomally‐abnormal pregnancies. To determine the MS‐CA 125 concentration, we used a new automated microparticle enzyme immunoassay with low inter‐assay variability. The median MS‐CA 125 level decreased from the first to the second trimester of pregnancy and was higher than that in non‐pregnant women. We found no difference between normal and Down's syndrome (n = 29) pregnancies ( t‐test: t = 0·57, p >0·5). The MS‐CA 125 levels in pregnancies with other chromosomal abnormalities showed no difference either, compared with the normals. We conclude that MS‐CA 125 is not a useful marker for fetal Down's syndrome, nor for other chromosomal disorders in pregnancy.</description><subject>Biological and medical sciences</subject><subject>CA 125</subject><subject>CA 125 antigen</subject><subject>Down's syndrome</subject><subject>Fetal chromosomal disorder</subject><subject>First-trimester screening</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>man</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>prenatal diagnosis</subject><issn>0197-3851</issn><issn>1097-0223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1993</creationdate><recordtype>article</recordtype><recordid>eNp9kElP3EAQhVsRSBmWY-59iLgZehm73UcyYWcAkQWkHFo17XIwaS90eSDz7zGa0US5cKoq1fdelR5jn6TYl0Kog67Yl9YIqaUS5gMbSWFNIpTSG2wkhk2i81R-ZFtEjwOeK2tG7NcUeowNBE4Y5zWfHHKpUh7wGQPxquFdxN8NNL5C4i9V_8D9Q2zrltoaQlgkTRuHhkNT8ARmq6nEfk5IO2yzhEC4u6rb7Mfx0ffJaXJ5fXI2ObxMvLKZSQrIytJKK6VFNMUYjNLodSlmvtSotZAKfZraLJPegDUa0HtMBY6NKWYK9DbbW_p2sX2aI_WurshjCNBgOycnM2O0HecDmCxBH1uiiKXrYlVDXDgp3FuErivcvwgH_vPKGMhDKONbDrQW6TyzqRQDZpbYSxVw8b6nu_n634HVQxX1-HethPjHZUab1N1dnbiL2y8_7_PpN3euXwFM35CR</recordid><startdate>199312</startdate><enddate>199312</enddate><creator>Van Lith, J. M. M.</creator><creator>Mantingh, A.</creator><creator>De Bruijn, H. W. A.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T3</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>199312</creationdate><title>Maternal serum CA 125 levels in pregnancies with chromosomally-normal and -abnormal fetuses</title><author>Van Lith, J. M. M. ; Mantingh, A. ; De Bruijn, H. W. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2967-da6ff919119ee7d4a723ec3f0bcf3e33012ec559661c7a973aecce50e477db2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1993</creationdate><topic>Biological and medical sciences</topic><topic>CA 125</topic><topic>CA 125 antigen</topic><topic>Down's syndrome</topic><topic>Fetal chromosomal disorder</topic><topic>First-trimester screening</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>man</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>prenatal diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Lith, J. M. M.</creatorcontrib><creatorcontrib>Mantingh, A.</creatorcontrib><creatorcontrib>De Bruijn, H. W. A.</creatorcontrib><creatorcontrib>For the Dutch Working Party on Prenatal Diagnosis</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Human Genome Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Prenatal diagnosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Lith, J. M. M.</au><au>Mantingh, A.</au><au>De Bruijn, H. W. A.</au><aucorp>For the Dutch Working Party on Prenatal Diagnosis</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal serum CA 125 levels in pregnancies with chromosomally-normal and -abnormal fetuses</atitle><jtitle>Prenatal diagnosis</jtitle><addtitle>Prenat. Diagn</addtitle><date>1993-12</date><risdate>1993</risdate><volume>13</volume><issue>12</issue><spage>1123</spage><epage>1131</epage><pages>1123-1131</pages><issn>0197-3851</issn><eissn>1097-0223</eissn><coden>PRDIDM</coden><abstract>We measured the maternal serum cancer antigen 125 (MS‐CA 125) levels in 98 nonpregnant women, 765 first‐ and second‐trimester pregnancies with chromosomally‐normal fetuses, and 54 chromosomally‐abnormal pregnancies. To determine the MS‐CA 125 concentration, we used a new automated microparticle enzyme immunoassay with low inter‐assay variability. The median MS‐CA 125 level decreased from the first to the second trimester of pregnancy and was higher than that in non‐pregnant women. We found no difference between normal and Down's syndrome (n = 29) pregnancies ( t‐test: t = 0·57, p >0·5). The MS‐CA 125 levels in pregnancies with other chromosomal abnormalities showed no difference either, compared with the normals. We conclude that MS‐CA 125 is not a useful marker for fetal Down's syndrome, nor for other chromosomal disorders in pregnancy.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><doi>10.1002/pd.1970131207</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0197-3851 |
| ispartof | Prenatal diagnosis, 1993-12, Vol.13 (12), p.1123-1131 |
| issn | 0197-3851 1097-0223 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16773948 |
| source | Access via Wiley Online Library |
| subjects | Biological and medical sciences CA 125 CA 125 antigen Down's syndrome Fetal chromosomal disorder First-trimester screening Gynecology. Andrology. Obstetrics man Management. Prenatal diagnosis Medical sciences Pregnancy. Fetus. Placenta prenatal diagnosis |
| title | Maternal serum CA 125 levels in pregnancies with chromosomally-normal and -abnormal fetuses |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-27T03%3A02%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Maternal%20serum%20CA%20125%20levels%20in%20pregnancies%20with%20chromosomally-normal%20and%20-abnormal%20fetuses&rft.jtitle=Prenatal%20diagnosis&rft.au=Van%20Lith,%20J.%20M.%20M.&rft.aucorp=For%20the%20Dutch%20Working%20Party%20on%20Prenatal%20Diagnosis&rft.date=1993-12&rft.volume=13&rft.issue=12&rft.spage=1123&rft.epage=1131&rft.pages=1123-1131&rft.issn=0197-3851&rft.eissn=1097-0223&rft.coden=PRDIDM&rft_id=info:doi/10.1002/pd.1970131207&rft_dat=%3Cproquest_cross%3E16773948%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=16773948&rft_id=info:pmid/&rfr_iscdi=true |