Co-targeting of Akt and Myc inhibits viability of lymphoma cells from Lck-Dlx5 mice

Constitutive activation of AKT is a frequent occurrence in the development of human T-cell acute lymphocytic leukemia/lymphomas (T-ALLs), due largely to inactivation of PTEN. Up regulation of MYC is also commonly observed in human T-ALLs. We previously demonstrated that expression of a constitutivel...

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Veröffentlicht in:	Cancer biology & therapy 2015-01, Vol.16 (4), p.580-588
Hauptverfasser:	Tan, Yinfei, Sementino, Eleonora, Pei, Jianming, Kadariya, Yuwaraj, Ito, Timothy K, Testa, Joseph R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis - drug effects Azepines - pharmacology Cell Cycle Checkpoints - drug effects cell cycle deregulation Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cell Survival - genetics Dlx5 homeobox gene Everolimus - pharmacology Homeodomain Proteins - metabolism Imidazoles - pharmacology Lymphocyte Specific Protein Tyrosine Kinase p56(lck) - metabolism Mice mouse tumor model Myc and Akt oncogenes Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-myc - metabolism Quinolines - pharmacology Research Paper Signal Transduction - drug effects T cell lymphoma Thiazoles - pharmacology Transcription, Genetic - drug effects Triazoles - pharmacology Vincristine - pharmacology
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