Modulation of protein synthesis by polyamines

Polyamines are ubiquitous small basic molecules that play important roles in cell growth and viability. Since polyamines mainly exist as a polyamine‐RNA complex, we looked for proteins whose synthesis is preferentially stimulated by polyamines at the level of translation, and thus far identified 17...

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Veröffentlicht in:	IUBMB life 2015-03, Vol.67 (3), p.160-169
Hauptverfasser:	Igarashi, Kazuei, Kashiwagi, Keiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bulged‐out region of RNA eIF5A Enzymes - metabolism Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - biosynthesis Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Eukaryotic Translation Initiation Factor 5A hypusine initiation Mammals mRNA structure Peptide Initiation Factors - metabolism Polyamines - metabolism Protein Biosynthesis protein synthesis Ribosomal Proteins - biosynthesis Ribosomal Proteins - genetics RNA, Bacterial - metabolism RNA-Binding Proteins - metabolism
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creator	Igarashi, Kazuei Kashiwagi, Keiko
description	Polyamines are ubiquitous small basic molecules that play important roles in cell growth and viability. Since polyamines mainly exist as a polyamine‐RNA complex, we looked for proteins whose synthesis is preferentially stimulated by polyamines at the level of translation, and thus far identified 17 proteins in Escherichia coli and 6 proteins in eukaryotes. The mechanisms of polyamine stimulation of synthesis of these proteins were investigated. In addition, the role of eIF5A, containing hypusine formed from spermidine, on protein synthesis is described. These results clearly indicate that polyamines and eIF5A contribute to cell growth and viability through modulation of protein synthesis. © 2015 IUBMB Life, 67(3):160–169, 2015
doi_str_mv	10.1002/iub.1363
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subjects	Animals bulged‐out region of RNA eIF5A Enzymes - metabolism Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins - biosynthesis Escherichia coli Proteins - genetics Escherichia coli Proteins - metabolism Eukaryotic Translation Initiation Factor 5A hypusine initiation Mammals mRNA structure Peptide Initiation Factors - metabolism Polyamines - metabolism Protein Biosynthesis protein synthesis Ribosomal Proteins - biosynthesis Ribosomal Proteins - genetics RNA, Bacterial - metabolism RNA-Binding Proteins - metabolism
title	Modulation of protein synthesis by polyamines
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