Extraurothelial recurrence after radical nephroureterectomy: preoperative predictors and survival
Objective To identify the preoperative predictors of extraurothelial recurrence (EUR) after radical nephroureterectomy (RNU) in patients with upper tract urothelial carcinoma (UTUC). Methods A single-center series of 238 consecutive patients who were treated with RNU for UTUC was evaluated. Recurren...
Gespeichert in:
| Veröffentlicht in: | International urology and nephrology 2015-05, Vol.47 (5), p.775-779 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 779 |
|---|---|
| container_issue | 5 |
| container_start_page | 775 |
| container_title | International urology and nephrology |
| container_volume | 47 |
| creator | Dzamic, Zoran Milojevic, Bogomir Kajmakovic, Boris Grozdic Milojevic, Isidora Bojanic, Nebojsa Sipetic Grujicic, Sandra |
| description | Objective
To identify the preoperative predictors of extraurothelial recurrence (EUR) after radical nephroureterectomy (RNU) in patients with upper tract urothelial carcinoma (UTUC).
Methods
A single-center series of 238 consecutive patients who were treated with RNU for UTUC was evaluated. Recurrence-free probabilities and cancer-specific survival (CSS) were estimated using the Kaplan–Meier method. Multivariate Cox proportional hazards regression models were used to evaluate the association between various clinicopathological factors and EUR.
Results
The median time to EUR was 17.6 months (range 3–73 months). EUR-free survival rates at 1, 3, 5, and 7 years were 87.8, 75.2, 73.5, and 72.6 %, respectively. In multivariate Cox regression analyses, tumor stage (HR 27.4; 95 % CI 7.83–95.8;
p
= 0.0001) and lymphovascular invasion (LVI) (HR 1.53; 95 % CI 1.22–3.12;
p
= 0.01) were independently associated with EUR. In patients with EUR, 5-year CSS estimate was 29.2 %. Tumor stage (HR 14.3; 95 % CI 4.55–45.2;
p
|
| doi_str_mv | 10.1007/s11255-015-0946-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1677378654</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1677378654</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-25f2c2f845cd83264af9dc5daf346c13dd0bd7adc3d846f9c66c8ab7a9254f6e3</originalsourceid><addsrcrecordid>eNp1kE1r3DAQhkVJ6G7S_oBegiGXXtzoW3JvYdmkhUAv7VlopVHjxWs7I3tJ_n21bFJCIAchpHnm1egh5Auj3xil5iozxpWqKSurkbq2H8iSKSNqrqw8IUsqKKuZ5mJBznLeUkobS-lHsuDKGC6sXBK_fpzQzzhM99C1vqsQwowIfYDKpwmwQh_bUAo9jPc4zAjlEsI07J6-VyPCMAL6qd3D4VDIacBc-T5WecZ9u_fdJ3KafJfh8_N-Tv7crH-vftR3v25_rq7v6iAMn8rIiQeerFQhWsG19KmJQUWfhNSBiRjpJhofg4hW6tQErYP1G-MbrmTSIM7J12PuiMPDDHlyuzYH6DrfwzBnx7QxwlitZEEv36Db8rG-THegGik447RQ7EgFHHJGSG7EdufxyTHqDv7d0b8r_t3Bv7Ol5-I5ed7sIP7veBFeAH4Ecin1fwFfPf1u6j-QyJLv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1679432120</pqid></control><display><type>article</type><title>Extraurothelial recurrence after radical nephroureterectomy: preoperative predictors and survival</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Dzamic, Zoran ; Milojevic, Bogomir ; Kajmakovic, Boris ; Grozdic Milojevic, Isidora ; Bojanic, Nebojsa ; Sipetic Grujicic, Sandra</creator><creatorcontrib>Dzamic, Zoran ; Milojevic, Bogomir ; Kajmakovic, Boris ; Grozdic Milojevic, Isidora ; Bojanic, Nebojsa ; Sipetic Grujicic, Sandra</creatorcontrib><description>Objective
To identify the preoperative predictors of extraurothelial recurrence (EUR) after radical nephroureterectomy (RNU) in patients with upper tract urothelial carcinoma (UTUC).
Methods
A single-center series of 238 consecutive patients who were treated with RNU for UTUC was evaluated. Recurrence-free probabilities and cancer-specific survival (CSS) were estimated using the Kaplan–Meier method. Multivariate Cox proportional hazards regression models were used to evaluate the association between various clinicopathological factors and EUR.
Results
The median time to EUR was 17.6 months (range 3–73 months). EUR-free survival rates at 1, 3, 5, and 7 years were 87.8, 75.2, 73.5, and 72.6 %, respectively. In multivariate Cox regression analyses, tumor stage (HR 27.4; 95 % CI 7.83–95.8;
p
= 0.0001) and lymphovascular invasion (LVI) (HR 1.53; 95 % CI 1.22–3.12;
p
= 0.01) were independently associated with EUR. In patients with EUR, 5-year CSS estimate was 29.2 %. Tumor stage (HR 14.3; 95 % CI 4.55–45.2;
p
< 0.001) and EUR (HR 2.7; 95 % CI 1.54–4.73;
p
= 0.001) were the only independent predictors associated with worse CSS.
Conclusions
EUR significantly affected the prognosis in patients with UTUC managed by RNU. Patient with EUR had a greater probability of having higher tumor stages, higher tumor grades, and positive LVI. Tumor stage and LVI were independently associated with a worse EUR-free survival.</description><identifier>ISSN: 0301-1623</identifier><identifier>EISSN: 1573-2584</identifier><identifier>DOI: 10.1007/s11255-015-0946-8</identifier><identifier>PMID: 25772384</identifier><identifier>CODEN: IURNAE</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Blood Vessels - pathology ; Carcinoma, Transitional Cell - drug therapy ; Carcinoma, Transitional Cell - secondary ; Carcinoma, Transitional Cell - surgery ; Chemotherapy, Adjuvant ; Cisplatin - administration & dosage ; Disease-Free Survival ; Female ; Humans ; Kidney Neoplasms - drug therapy ; Kidney Neoplasms - pathology ; Kidney Neoplasms - surgery ; Lymphatic Metastasis ; Lymphatic Vessels - pathology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - pathology ; Neoplasm Staging ; Nephrectomy ; Nephrology ; Survival Rate ; Ureter - surgery ; Ureteral Neoplasms - drug therapy ; Ureteral Neoplasms - pathology ; Ureteral Neoplasms - surgery ; Urology ; Urology - Original Paper</subject><ispartof>International urology and nephrology, 2015-05, Vol.47 (5), p.775-779</ispartof><rights>Springer Science+Business Media Dordrecht 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-25f2c2f845cd83264af9dc5daf346c13dd0bd7adc3d846f9c66c8ab7a9254f6e3</citedby><cites>FETCH-LOGICAL-c372t-25f2c2f845cd83264af9dc5daf346c13dd0bd7adc3d846f9c66c8ab7a9254f6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11255-015-0946-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11255-015-0946-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25772384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dzamic, Zoran</creatorcontrib><creatorcontrib>Milojevic, Bogomir</creatorcontrib><creatorcontrib>Kajmakovic, Boris</creatorcontrib><creatorcontrib>Grozdic Milojevic, Isidora</creatorcontrib><creatorcontrib>Bojanic, Nebojsa</creatorcontrib><creatorcontrib>Sipetic Grujicic, Sandra</creatorcontrib><title>Extraurothelial recurrence after radical nephroureterectomy: preoperative predictors and survival</title><title>International urology and nephrology</title><addtitle>Int Urol Nephrol</addtitle><addtitle>Int Urol Nephrol</addtitle><description>Objective
To identify the preoperative predictors of extraurothelial recurrence (EUR) after radical nephroureterectomy (RNU) in patients with upper tract urothelial carcinoma (UTUC).
Methods
A single-center series of 238 consecutive patients who were treated with RNU for UTUC was evaluated. Recurrence-free probabilities and cancer-specific survival (CSS) were estimated using the Kaplan–Meier method. Multivariate Cox proportional hazards regression models were used to evaluate the association between various clinicopathological factors and EUR.
Results
The median time to EUR was 17.6 months (range 3–73 months). EUR-free survival rates at 1, 3, 5, and 7 years were 87.8, 75.2, 73.5, and 72.6 %, respectively. In multivariate Cox regression analyses, tumor stage (HR 27.4; 95 % CI 7.83–95.8;
p
= 0.0001) and lymphovascular invasion (LVI) (HR 1.53; 95 % CI 1.22–3.12;
p
= 0.01) were independently associated with EUR. In patients with EUR, 5-year CSS estimate was 29.2 %. Tumor stage (HR 14.3; 95 % CI 4.55–45.2;
p
< 0.001) and EUR (HR 2.7; 95 % CI 1.54–4.73;
p
= 0.001) were the only independent predictors associated with worse CSS.
Conclusions
EUR significantly affected the prognosis in patients with UTUC managed by RNU. Patient with EUR had a greater probability of having higher tumor stages, higher tumor grades, and positive LVI. Tumor stage and LVI were independently associated with a worse EUR-free survival.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Blood Vessels - pathology</subject><subject>Carcinoma, Transitional Cell - drug therapy</subject><subject>Carcinoma, Transitional Cell - secondary</subject><subject>Carcinoma, Transitional Cell - surgery</subject><subject>Chemotherapy, Adjuvant</subject><subject>Cisplatin - administration & dosage</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Humans</subject><subject>Kidney Neoplasms - drug therapy</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - surgery</subject><subject>Lymphatic Metastasis</subject><subject>Lymphatic Vessels - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Staging</subject><subject>Nephrectomy</subject><subject>Nephrology</subject><subject>Survival Rate</subject><subject>Ureter - surgery</subject><subject>Ureteral Neoplasms - drug therapy</subject><subject>Ureteral Neoplasms - pathology</subject><subject>Ureteral Neoplasms - surgery</subject><subject>Urology</subject><subject>Urology - Original Paper</subject><issn>0301-1623</issn><issn>1573-2584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1r3DAQhkVJ6G7S_oBegiGXXtzoW3JvYdmkhUAv7VlopVHjxWs7I3tJ_n21bFJCIAchpHnm1egh5Auj3xil5iozxpWqKSurkbq2H8iSKSNqrqw8IUsqKKuZ5mJBznLeUkobS-lHsuDKGC6sXBK_fpzQzzhM99C1vqsQwowIfYDKpwmwQh_bUAo9jPc4zAjlEsI07J6-VyPCMAL6qd3D4VDIacBc-T5WecZ9u_fdJ3KafJfh8_N-Tv7crH-vftR3v25_rq7v6iAMn8rIiQeerFQhWsG19KmJQUWfhNSBiRjpJhofg4hW6tQErYP1G-MbrmTSIM7J12PuiMPDDHlyuzYH6DrfwzBnx7QxwlitZEEv36Db8rG-THegGik447RQ7EgFHHJGSG7EdufxyTHqDv7d0b8r_t3Bv7Ol5-I5ed7sIP7veBFeAH4Ecin1fwFfPf1u6j-QyJLv</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Dzamic, Zoran</creator><creator>Milojevic, Bogomir</creator><creator>Kajmakovic, Boris</creator><creator>Grozdic Milojevic, Isidora</creator><creator>Bojanic, Nebojsa</creator><creator>Sipetic Grujicic, Sandra</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150501</creationdate><title>Extraurothelial recurrence after radical nephroureterectomy: preoperative predictors and survival</title><author>Dzamic, Zoran ; Milojevic, Bogomir ; Kajmakovic, Boris ; Grozdic Milojevic, Isidora ; Bojanic, Nebojsa ; Sipetic Grujicic, Sandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-25f2c2f845cd83264af9dc5daf346c13dd0bd7adc3d846f9c66c8ab7a9254f6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Blood Vessels - pathology</topic><topic>Carcinoma, Transitional Cell - drug therapy</topic><topic>Carcinoma, Transitional Cell - secondary</topic><topic>Carcinoma, Transitional Cell - surgery</topic><topic>Chemotherapy, Adjuvant</topic><topic>Cisplatin - administration & dosage</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Humans</topic><topic>Kidney Neoplasms - drug therapy</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - surgery</topic><topic>Lymphatic Metastasis</topic><topic>Lymphatic Vessels - pathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Staging</topic><topic>Nephrectomy</topic><topic>Nephrology</topic><topic>Survival Rate</topic><topic>Ureter - surgery</topic><topic>Ureteral Neoplasms - drug therapy</topic><topic>Ureteral Neoplasms - pathology</topic><topic>Ureteral Neoplasms - surgery</topic><topic>Urology</topic><topic>Urology - Original Paper</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dzamic, Zoran</creatorcontrib><creatorcontrib>Milojevic, Bogomir</creatorcontrib><creatorcontrib>Kajmakovic, Boris</creatorcontrib><creatorcontrib>Grozdic Milojevic, Isidora</creatorcontrib><creatorcontrib>Bojanic, Nebojsa</creatorcontrib><creatorcontrib>Sipetic Grujicic, Sandra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International urology and nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dzamic, Zoran</au><au>Milojevic, Bogomir</au><au>Kajmakovic, Boris</au><au>Grozdic Milojevic, Isidora</au><au>Bojanic, Nebojsa</au><au>Sipetic Grujicic, Sandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extraurothelial recurrence after radical nephroureterectomy: preoperative predictors and survival</atitle><jtitle>International urology and nephrology</jtitle><stitle>Int Urol Nephrol</stitle><addtitle>Int Urol Nephrol</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>47</volume><issue>5</issue><spage>775</spage><epage>779</epage><pages>775-779</pages><issn>0301-1623</issn><eissn>1573-2584</eissn><coden>IURNAE</coden><abstract>Objective
To identify the preoperative predictors of extraurothelial recurrence (EUR) after radical nephroureterectomy (RNU) in patients with upper tract urothelial carcinoma (UTUC).
Methods
A single-center series of 238 consecutive patients who were treated with RNU for UTUC was evaluated. Recurrence-free probabilities and cancer-specific survival (CSS) were estimated using the Kaplan–Meier method. Multivariate Cox proportional hazards regression models were used to evaluate the association between various clinicopathological factors and EUR.
Results
The median time to EUR was 17.6 months (range 3–73 months). EUR-free survival rates at 1, 3, 5, and 7 years were 87.8, 75.2, 73.5, and 72.6 %, respectively. In multivariate Cox regression analyses, tumor stage (HR 27.4; 95 % CI 7.83–95.8;
p
= 0.0001) and lymphovascular invasion (LVI) (HR 1.53; 95 % CI 1.22–3.12;
p
= 0.01) were independently associated with EUR. In patients with EUR, 5-year CSS estimate was 29.2 %. Tumor stage (HR 14.3; 95 % CI 4.55–45.2;
p
< 0.001) and EUR (HR 2.7; 95 % CI 1.54–4.73;
p
= 0.001) were the only independent predictors associated with worse CSS.
Conclusions
EUR significantly affected the prognosis in patients with UTUC managed by RNU. Patient with EUR had a greater probability of having higher tumor stages, higher tumor grades, and positive LVI. Tumor stage and LVI were independently associated with a worse EUR-free survival.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>25772384</pmid><doi>10.1007/s11255-015-0946-8</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-1623 |
| ispartof | International urology and nephrology, 2015-05, Vol.47 (5), p.775-779 |
| issn | 0301-1623 1573-2584 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1677378654 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - therapeutic use Blood Vessels - pathology Carcinoma, Transitional Cell - drug therapy Carcinoma, Transitional Cell - secondary Carcinoma, Transitional Cell - surgery Chemotherapy, Adjuvant Cisplatin - administration & dosage Disease-Free Survival Female Humans Kidney Neoplasms - drug therapy Kidney Neoplasms - pathology Kidney Neoplasms - surgery Lymphatic Metastasis Lymphatic Vessels - pathology Male Medicine Medicine & Public Health Middle Aged Neoplasm Invasiveness Neoplasm Recurrence, Local - pathology Neoplasm Staging Nephrectomy Nephrology Survival Rate Ureter - surgery Ureteral Neoplasms - drug therapy Ureteral Neoplasms - pathology Ureteral Neoplasms - surgery Urology Urology - Original Paper |
| title | Extraurothelial recurrence after radical nephroureterectomy: preoperative predictors and survival |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T15%3A15%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Extraurothelial%20recurrence%20after%20radical%20nephroureterectomy:%20preoperative%20predictors%20and%20survival&rft.jtitle=International%20urology%20and%20nephrology&rft.au=Dzamic,%20Zoran&rft.date=2015-05-01&rft.volume=47&rft.issue=5&rft.spage=775&rft.epage=779&rft.pages=775-779&rft.issn=0301-1623&rft.eissn=1573-2584&rft.coden=IURNAE&rft_id=info:doi/10.1007/s11255-015-0946-8&rft_dat=%3Cproquest_cross%3E1677378654%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1679432120&rft_id=info:pmid/25772384&rfr_iscdi=true |