Association between SNPs of Metalloproteinases and Prostaglandin F2α Receptor Genes and Latanoprost Response in Open-Angle Glaucoma

Purpose To determine whether single nucleotide polymorphisms (SNPs) of genes coding for matrix metalloproteinases (MMPs) and the prostaglandin F2α receptor gene ( PTGFR ) are related to a response to latanoprost in a white Spanish population of glaucomatous patients. Design Case–control study. Parti...

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Veröffentlicht in:	Ophthalmology (Rochester, Minn.) Minn.), 2015-05, Vol.122 (5), p.1040-1048.e4
Hauptverfasser:	Ussa, Fernando, MD, PhD, Fernandez, Itziar, PhD, Brion, Maria, MD, PhD, Carracedo, Angel, MD, PhD, Blazquez, Francisco, MD, MSc, Garcia, Maria T., MSc, Sanchez-Jara, Ana, MD, PhD, De Juan-Marcos, Lourdes, MD, PhD, Jimenez-Carmona, Soledad, MD, PhD, Juberias, Jose R., MD, PhD, Martinez-de-la-Casa, Jose M., MD, PhD, Pastor, Jose C., MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antihypertensive Agents - therapeutic use Case-Control Studies Female Genotyping Techniques Glaucoma, Open-Angle - drug therapy Glaucoma, Open-Angle - genetics Humans Intraocular Pressure - drug effects Latanoprost Male Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinases - genetics Middle Aged Ophthalmology Polymerase Chain Reaction Polymorphism, Single Nucleotide Prostaglandins F, Synthetic - therapeutic use Receptors, Prostaglandin - genetics
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