Storage of magnetization as singlet order by optimal control designed pulses
Purpose The use of hyperpolarization to enhance the sensitivity of MRI has so far been limited by the decay of the polarization through T1 relaxation. Recently, methods have been proposed that extend the lifetime of the hyperpolarization by storing the spin order in slowly relaxing singlet states. M...
Gespeichert in:
| Veröffentlicht in: | Magnetic resonance in medicine 2014-03, Vol.71 (3), p.921-926 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 926 |
|---|---|
| container_issue | 3 |
| container_start_page | 921 |
| container_title | Magnetic resonance in medicine |
| container_volume | 71 |
| creator | Laustsen, Christoffer Bowen, Sean Vinding, Mads Sloth Nielsen, Niels Chr Ardenkjaer-Larsen, Jan H. |
| description | Purpose
The use of hyperpolarization to enhance the sensitivity of MRI has so far been limited by the decay of the polarization through T1 relaxation. Recently, methods have been proposed that extend the lifetime of the hyperpolarization by storing the spin order in slowly relaxing singlet states.
Methods
With this aim, optimal control theory was applied to create pulses that for near‐equivalent spins accomplish transfers in and out of the singlet state with maximum efficiency while ensuring robustness toward variations in the nuclear spin system Hamiltonian (chemical shift, J‐couplings, B1 and B0 magnetic field inhomogeneity).
Results
The pulses are designed to accomplish efficient transfer with low B1 amplitude, essential for applications on preclinical and clinical MR scanners.
Conclusion
It is demonstrated that significantly improved efficiency and robustness can be obtained within the limitations of typical MR scanner performance. Magn Reson Med 71:921–926, 2014. © 2013 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/mrm.24733 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1677373977</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3225275741</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4243-b85754d1e4ac1fbdbc9456304f05196a09c9f5fb2d4b43886118a206c8e53e6f3</originalsourceid><addsrcrecordid>eNqFkUGP0zAQhS0EYruFA38AWeLCHrI79tiJfYQVLUgtSBSExMVyEqfKksTFTrRbfj1e2u4BCXGZmcP3njTvEfKCwSUD4Fd96C-5KBAfkRmTnGdcavGYzKAQkCHT4oycx3gDAFoX4ik54yilAKZmZLUZfbBbR31De7sd3Nj-smPrB2ojje2w7dxIfahdoOWe-t3Y9rajlR_G4Dtau9gmTU13UxddfEaeNDYdz497Tr4u3n25fp-tPi0_XL9ZZZXgArNSyUKKmjlhK9aUdVlpIXME0YBkOregK93IpuS1KAUqlTOmLIe8Uk6iyxuck9cH313wPycXR9O3sXJdZwfnp2hYXhRYoE7zv6gEiahQY0Jf_YXe-CkM6ZF7ChRHDipRFweqCj7G4BqzCymTsDcMzH0bJrVh_rSR2JdHx6nsXf1AnuJPwNUBuG07t_-3k1l_Xp8ss4OijaO7e1DY8MPk6Wdpvn1cmqX-_nbDeWEW-BtmOaE4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1500823208</pqid></control><display><type>article</type><title>Storage of magnetization as singlet order by optimal control designed pulses</title><source>MEDLINE</source><source>Wiley Free Archive</source><source>Wiley Blackwell Single Titles</source><creator>Laustsen, Christoffer ; Bowen, Sean ; Vinding, Mads Sloth ; Nielsen, Niels Chr ; Ardenkjaer-Larsen, Jan H.</creator><creatorcontrib>Laustsen, Christoffer ; Bowen, Sean ; Vinding, Mads Sloth ; Nielsen, Niels Chr ; Ardenkjaer-Larsen, Jan H.</creatorcontrib><description>Purpose
The use of hyperpolarization to enhance the sensitivity of MRI has so far been limited by the decay of the polarization through T1 relaxation. Recently, methods have been proposed that extend the lifetime of the hyperpolarization by storing the spin order in slowly relaxing singlet states.
Methods
With this aim, optimal control theory was applied to create pulses that for near‐equivalent spins accomplish transfers in and out of the singlet state with maximum efficiency while ensuring robustness toward variations in the nuclear spin system Hamiltonian (chemical shift, J‐couplings, B1 and B0 magnetic field inhomogeneity).
Results
The pulses are designed to accomplish efficient transfer with low B1 amplitude, essential for applications on preclinical and clinical MR scanners.
Conclusion
It is demonstrated that significantly improved efficiency and robustness can be obtained within the limitations of typical MR scanner performance. Magn Reson Med 71:921–926, 2014. © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 0740-3194</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.24733</identifier><identifier>PMID: 23554018</identifier><identifier>CODEN: MRMEEN</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Algorithms ; Biopolymers - analysis ; DNP ; Feedback ; hyperpolarization ; long-lived singlet states ; Magnetic Resonance Spectroscopy - methods ; optimal control ; Reproducibility of Results ; Sensitivity and Specificity ; Signal Processing, Computer-Assisted ; Spin Labels</subject><ispartof>Magnetic resonance in medicine, 2014-03, Vol.71 (3), p.921-926</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4243-b85754d1e4ac1fbdbc9456304f05196a09c9f5fb2d4b43886118a206c8e53e6f3</citedby><cites>FETCH-LOGICAL-c4243-b85754d1e4ac1fbdbc9456304f05196a09c9f5fb2d4b43886118a206c8e53e6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.24733$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.24733$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,1432,27923,27924,45573,45574,46408,46832</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23554018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Laustsen, Christoffer</creatorcontrib><creatorcontrib>Bowen, Sean</creatorcontrib><creatorcontrib>Vinding, Mads Sloth</creatorcontrib><creatorcontrib>Nielsen, Niels Chr</creatorcontrib><creatorcontrib>Ardenkjaer-Larsen, Jan H.</creatorcontrib><title>Storage of magnetization as singlet order by optimal control designed pulses</title><title>Magnetic resonance in medicine</title><addtitle>Magn. Reson. Med</addtitle><description>Purpose
The use of hyperpolarization to enhance the sensitivity of MRI has so far been limited by the decay of the polarization through T1 relaxation. Recently, methods have been proposed that extend the lifetime of the hyperpolarization by storing the spin order in slowly relaxing singlet states.
Methods
With this aim, optimal control theory was applied to create pulses that for near‐equivalent spins accomplish transfers in and out of the singlet state with maximum efficiency while ensuring robustness toward variations in the nuclear spin system Hamiltonian (chemical shift, J‐couplings, B1 and B0 magnetic field inhomogeneity).
Results
The pulses are designed to accomplish efficient transfer with low B1 amplitude, essential for applications on preclinical and clinical MR scanners.
Conclusion
It is demonstrated that significantly improved efficiency and robustness can be obtained within the limitations of typical MR scanner performance. Magn Reson Med 71:921–926, 2014. © 2013 Wiley Periodicals, Inc.</description><subject>Algorithms</subject><subject>Biopolymers - analysis</subject><subject>DNP</subject><subject>Feedback</subject><subject>hyperpolarization</subject><subject>long-lived singlet states</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>optimal control</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Signal Processing, Computer-Assisted</subject><subject>Spin Labels</subject><issn>0740-3194</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUGP0zAQhS0EYruFA38AWeLCHrI79tiJfYQVLUgtSBSExMVyEqfKksTFTrRbfj1e2u4BCXGZmcP3njTvEfKCwSUD4Fd96C-5KBAfkRmTnGdcavGYzKAQkCHT4oycx3gDAFoX4ik54yilAKZmZLUZfbBbR31De7sd3Nj-smPrB2ojje2w7dxIfahdoOWe-t3Y9rajlR_G4Dtau9gmTU13UxddfEaeNDYdz497Tr4u3n25fp-tPi0_XL9ZZZXgArNSyUKKmjlhK9aUdVlpIXME0YBkOregK93IpuS1KAUqlTOmLIe8Uk6iyxuck9cH313wPycXR9O3sXJdZwfnp2hYXhRYoE7zv6gEiahQY0Jf_YXe-CkM6ZF7ChRHDipRFweqCj7G4BqzCymTsDcMzH0bJrVh_rSR2JdHx6nsXf1AnuJPwNUBuG07t_-3k1l_Xp8ss4OijaO7e1DY8MPk6Wdpvn1cmqX-_nbDeWEW-BtmOaE4</recordid><startdate>201403</startdate><enddate>201403</enddate><creator>Laustsen, Christoffer</creator><creator>Bowen, Sean</creator><creator>Vinding, Mads Sloth</creator><creator>Nielsen, Niels Chr</creator><creator>Ardenkjaer-Larsen, Jan H.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7QO</scope><scope>7X8</scope></search><sort><creationdate>201403</creationdate><title>Storage of magnetization as singlet order by optimal control designed pulses</title><author>Laustsen, Christoffer ; Bowen, Sean ; Vinding, Mads Sloth ; Nielsen, Niels Chr ; Ardenkjaer-Larsen, Jan H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4243-b85754d1e4ac1fbdbc9456304f05196a09c9f5fb2d4b43886118a206c8e53e6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Algorithms</topic><topic>Biopolymers - analysis</topic><topic>DNP</topic><topic>Feedback</topic><topic>hyperpolarization</topic><topic>long-lived singlet states</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>optimal control</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Signal Processing, Computer-Assisted</topic><topic>Spin Labels</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laustsen, Christoffer</creatorcontrib><creatorcontrib>Bowen, Sean</creatorcontrib><creatorcontrib>Vinding, Mads Sloth</creatorcontrib><creatorcontrib>Nielsen, Niels Chr</creatorcontrib><creatorcontrib>Ardenkjaer-Larsen, Jan H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laustsen, Christoffer</au><au>Bowen, Sean</au><au>Vinding, Mads Sloth</au><au>Nielsen, Niels Chr</au><au>Ardenkjaer-Larsen, Jan H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Storage of magnetization as singlet order by optimal control designed pulses</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn. Reson. Med</addtitle><date>2014-03</date><risdate>2014</risdate><volume>71</volume><issue>3</issue><spage>921</spage><epage>926</epage><pages>921-926</pages><issn>0740-3194</issn><eissn>1522-2594</eissn><coden>MRMEEN</coden><abstract>Purpose
The use of hyperpolarization to enhance the sensitivity of MRI has so far been limited by the decay of the polarization through T1 relaxation. Recently, methods have been proposed that extend the lifetime of the hyperpolarization by storing the spin order in slowly relaxing singlet states.
Methods
With this aim, optimal control theory was applied to create pulses that for near‐equivalent spins accomplish transfers in and out of the singlet state with maximum efficiency while ensuring robustness toward variations in the nuclear spin system Hamiltonian (chemical shift, J‐couplings, B1 and B0 magnetic field inhomogeneity).
Results
The pulses are designed to accomplish efficient transfer with low B1 amplitude, essential for applications on preclinical and clinical MR scanners.
Conclusion
It is demonstrated that significantly improved efficiency and robustness can be obtained within the limitations of typical MR scanner performance. Magn Reson Med 71:921–926, 2014. © 2013 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23554018</pmid><doi>10.1002/mrm.24733</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0740-3194 |
| ispartof | Magnetic resonance in medicine, 2014-03, Vol.71 (3), p.921-926 |
| issn | 0740-3194 1522-2594 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1677373977 |
| source | MEDLINE; Wiley Free Archive; Wiley Blackwell Single Titles |
| subjects | Algorithms Biopolymers - analysis DNP Feedback hyperpolarization long-lived singlet states Magnetic Resonance Spectroscopy - methods optimal control Reproducibility of Results Sensitivity and Specificity Signal Processing, Computer-Assisted Spin Labels |
| title | Storage of magnetization as singlet order by optimal control designed pulses |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T15%3A32%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Storage%20of%20magnetization%20as%20singlet%20order%20by%20optimal%20control%20designed%20pulses&rft.jtitle=Magnetic%20resonance%20in%20medicine&rft.au=Laustsen,%20Christoffer&rft.date=2014-03&rft.volume=71&rft.issue=3&rft.spage=921&rft.epage=926&rft.pages=921-926&rft.issn=0740-3194&rft.eissn=1522-2594&rft.coden=MRMEEN&rft_id=info:doi/10.1002/mrm.24733&rft_dat=%3Cproquest_cross%3E3225275741%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1500823208&rft_id=info:pmid/23554018&rfr_iscdi=true |