Complex segregation analysis of antibodies to thyroid peroxidase in old order amish families

Autoimmune thyroid disease (AITD) may be characterized by the measurement in serum of antibodies to thyroid peroxidase. A population of Old Order Amish individuals and families was investigated to determine the prevalence of these antibodies and to examine hypotheses about the mode of transmission o...

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Veröffentlicht in:	American journal of medical genetics 1993-09, Vol.47 (3), p.375-379
Hauptverfasser:	Pauls, David L., Zakarija, Margita, McKenzie, J. Maxwell, Egeland, Janice A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult antibodies Autoantibodies - genetics Autoantibodies - immunology autoimmune diseases Autoimmunity - genetics autommune thyroid disease Biological and medical sciences Child Child, Preschool Disease Susceptibility - immunology Endocrinopathies Ethnic Groups - genetics Female Genetic Predisposition to Disease genetics Hashimoto's thyroiditis Humans Infant Iodide Peroxidase - immunology Male man Medical sciences Models, Genetic Non tumoral diseases. Target tissue resistance. Benign neoplasms Old Order Amish peroxidase polygenic background population genetics segregation thyroid diseases Thyroid. Thyroid axis (diseases) Thyroiditis, Autoimmune - genetics Thyroiditis, Autoimmune - immunology
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