Differential Tubulogenic and Branching Morphogenetic Activities of Growth Factors: Implications for Epithelial Tissue Development

At least two kidney epithelial cell lines, the Madin-Darby canine kidney (MDCK) and the murine inner medullary collecting duct line mIMCD-3, can be induced to form branching tubular structures when cultured with hepatocyte growth factor (HGF) plus serum in collagen I gels. In our studies, whereas MD...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1995-05, Vol.92 (10), p.4412-4416
Hauptverfasser:	Elvino J. G. Barros, Oscar F. P. Santos, Matsumoto, Kunio, Nakamura, Toshikazu, Nigam, Sanjay K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell growth Cell Line Cell lines Cells Collagen Collagens Culture Media, Serum-Free DNA - biosynthesis Dogs Embryo, Mammalian Epidermal Growth Factor - pharmacology Epithelial Cells Epithelium - drug effects Epithelium - ultrastructure Gels Growth Substances - pharmacology Hepatocyte Growth Factor - pharmacology Hepatocytes Immune Sera - pharmacology Kidney Kidney Tubules, Collecting Kidneys Mice Morphogenesis Morphogenesis - drug effects Rats Transforming Growth Factor alpha - pharmacology Tubular structures
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