Centrally-administered glycine antagonists increase locomotion in monoamine-depleted mice

It was shown in the present study that several structurally diverse antagonists of the glycine site of the NMDA receptor, including (R)-HA-966, L689,560, 5,7-dichlorokynurenic acid, 7-chlorokynurenic acid, and two of ZENECA's novel pyridazinoindole glycine antagonists, caused marked reversal of...

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Veröffentlicht in:	Journal of Neural Transmission 1994-01, Vol.97 (3), p.175-185
Hauptverfasser:	SLUSHER, B. S, RISSOLO, K. C, JACKSON, P. F, PULLAN, L. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Behavior, Animal - drug effects Biogenic Monoamines - physiology Biological and medical sciences glycine Glycine - antagonists & inhibitors Male Medical sciences Mice Motor Activity - drug effects Neuropharmacology Pharmacology. Drug treatments Pyrrolidinones - pharmacology Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Serine - pharmacology Stimulation, Chemical
Online-Zugang:	Volltext
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