Centrally-administered glycine antagonists increase locomotion in monoamine-depleted mice
It was shown in the present study that several structurally diverse antagonists of the glycine site of the NMDA receptor, including (R)-HA-966, L689,560, 5,7-dichlorokynurenic acid, 7-chlorokynurenic acid, and two of ZENECA's novel pyridazinoindole glycine antagonists, caused marked reversal of...
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| Veröffentlicht in: | Journal of Neural Transmission 1994-01, Vol.97 (3), p.175-185 |
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| container_end_page | 185 |
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| container_title | Journal of Neural Transmission |
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| creator | SLUSHER, B. S RISSOLO, K. C JACKSON, P. F PULLAN, L. M |
| description | It was shown in the present study that several structurally diverse antagonists of the glycine site of the NMDA receptor, including (R)-HA-966, L689,560, 5,7-dichlorokynurenic acid, 7-chlorokynurenic acid, and two of ZENECA's novel pyridazinoindole glycine antagonists, caused marked reversal of akinesia when administered intrastriatally to monoamine depleted mice. Coinjection of the glycine agonist D-serine antagonized this locomotor stimulation. In addition, all glycine antagonists tested did not cause significant locomotor stimulation when intrastriatally administered to normal mice. These data suggest that glycine antagonists may offer therapeutic utility in the treatment of idiopathic Parkinson's disease. |
| doi_str_mv | 10.1007/BF02336139 |
| format | Article |
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These data suggest that glycine antagonists may offer therapeutic utility in the treatment of idiopathic Parkinson's disease.</description><identifier>ISSN: 0300-9564</identifier><identifier>EISSN: 1435-1463</identifier><identifier>DOI: 10.1007/BF02336139</identifier><identifier>PMID: 7873128</identifier><identifier>CODEN: JNTMAH</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Animals ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Behavior, Animal - drug effects ; Biogenic Monoamines - physiology ; Biological and medical sciences ; glycine ; Glycine - antagonists & inhibitors ; Male ; Medical sciences ; Mice ; Motor Activity - drug effects ; Neuropharmacology ; Pharmacology. 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S</creatorcontrib><creatorcontrib>RISSOLO, K. C</creatorcontrib><creatorcontrib>JACKSON, P. F</creatorcontrib><creatorcontrib>PULLAN, L. M</creatorcontrib><title>Centrally-administered glycine antagonists increase locomotion in monoamine-depleted mice</title><title>Journal of Neural Transmission</title><addtitle>J Neural Transm Gen Sect</addtitle><description>It was shown in the present study that several structurally diverse antagonists of the glycine site of the NMDA receptor, including (R)-HA-966, L689,560, 5,7-dichlorokynurenic acid, 7-chlorokynurenic acid, and two of ZENECA's novel pyridazinoindole glycine antagonists, caused marked reversal of akinesia when administered intrastriatally to monoamine depleted mice. Coinjection of the glycine agonist D-serine antagonized this locomotor stimulation. In addition, all glycine antagonists tested did not cause significant locomotor stimulation when intrastriatally administered to normal mice. These data suggest that glycine antagonists may offer therapeutic utility in the treatment of idiopathic Parkinson's disease.</description><subject>Animals</subject><subject>Anticonvulsants. Antiepileptics. Antiparkinson agents</subject><subject>Behavior, Animal - drug effects</subject><subject>Biogenic Monoamines - physiology</subject><subject>Biological and medical sciences</subject><subject>glycine</subject><subject>Glycine - antagonists & inhibitors</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Motor Activity - drug effects</subject><subject>Neuropharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pyrrolidinones - pharmacology</subject><subject>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</subject><subject>Serine - pharmacology</subject><subject>Stimulation, Chemical</subject><issn>0300-9564</issn><issn>1435-1463</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkb1PwzAUxC0EKqWwsCNlQAxIAX8kdjJCRQGpEgsMTJE_nisjxy52OvS_J1WrMj3p7nc33EPomuAHgrF4fF5gyhgnrD1BU1KxuiQVZ6doihnGZVvz6hxd5PyDMSZENBM0EY1ghDZT9D2HMCTp_baUpnfB5QESmGLlt9oFKGQY5Cru5Fy4oBPIDIWPOvZxcDGMWtHHEOUYhdLA2sMwpnun4RKdWekzXB3uDH0tXj7nb-Xy4_V9_rQsNSNkKBVXxCrVKmWEoq0WlnFtbK2EkBRsoyouSKUqQ7mx0krZUCxqylpQNSiO2Qzd7XvXKf5uIA9d77IG72WAuMkd4YJzUbcjeL8HdYo5J7DdOrlepm1HcLfbsfvfcYRvDq0b1YM5oofhRv_24MuspbdJBu3yEasoJfX4gz8WyXw6</recordid><startdate>19940101</startdate><enddate>19940101</enddate><creator>SLUSHER, B. S</creator><creator>RISSOLO, K. C</creator><creator>JACKSON, P. 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Antiparkinson agents</topic><topic>Behavior, Animal - drug effects</topic><topic>Biogenic Monoamines - physiology</topic><topic>Biological and medical sciences</topic><topic>glycine</topic><topic>Glycine - antagonists & inhibitors</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Motor Activity - drug effects</topic><topic>Neuropharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pyrrolidinones - pharmacology</topic><topic>Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors</topic><topic>Serine - pharmacology</topic><topic>Stimulation, Chemical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SLUSHER, B. S</creatorcontrib><creatorcontrib>RISSOLO, K. C</creatorcontrib><creatorcontrib>JACKSON, P. F</creatorcontrib><creatorcontrib>PULLAN, L. 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M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Centrally-administered glycine antagonists increase locomotion in monoamine-depleted mice</atitle><jtitle>Journal of Neural Transmission</jtitle><addtitle>J Neural Transm Gen Sect</addtitle><date>1994-01-01</date><risdate>1994</risdate><volume>97</volume><issue>3</issue><spage>175</spage><epage>185</epage><pages>175-185</pages><issn>0300-9564</issn><eissn>1435-1463</eissn><coden>JNTMAH</coden><abstract>It was shown in the present study that several structurally diverse antagonists of the glycine site of the NMDA receptor, including (R)-HA-966, L689,560, 5,7-dichlorokynurenic acid, 7-chlorokynurenic acid, and two of ZENECA's novel pyridazinoindole glycine antagonists, caused marked reversal of akinesia when administered intrastriatally to monoamine depleted mice. Coinjection of the glycine agonist D-serine antagonized this locomotor stimulation. 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| ispartof | Journal of Neural Transmission, 1994-01, Vol.97 (3), p.175-185 |
| issn | 0300-9564 1435-1463 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Behavior, Animal - drug effects Biogenic Monoamines - physiology Biological and medical sciences glycine Glycine - antagonists & inhibitors Male Medical sciences Mice Motor Activity - drug effects Neuropharmacology Pharmacology. Drug treatments Pyrrolidinones - pharmacology Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Serine - pharmacology Stimulation, Chemical |
| title | Centrally-administered glycine antagonists increase locomotion in monoamine-depleted mice |
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