Isolation of β-Indomycinone Guided by Cytotoxicity Tests from Streptomyces sp. IFM11607 and Revision of its Double Bond Geometry

The antibiotic β-indomycinone was isolated from Streptomyces sp. IFM11607 by cytotoxicity-guided fractionation against human gastric adenocarcinoma AGS cells, and the geometry of its Δ17,18-double bond was revised from E to Z based on the coupling constant.

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Bibliographische Detailangaben
Veröffentlicht in:	Natural product communications 2014-09, Vol.9 (9), p.1327-1328
Hauptverfasser:	Tsukahara, Kentaro, Toume, Kazufumi, Ito, Hanako, Ishikawa, Naoki, Ishibashi, Masami
Format:	Artikel
Sprache:	eng
Schlagworte:	Anthraquinones - chemistry Anthraquinones - isolation & purification Anthraquinones - metabolism Anthraquinones - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Survival - drug effects Humans Molecular Structure Streptomyces - chemistry Streptomyces - metabolism
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Beschreibung
Zusammenfassung:	The antibiotic β-indomycinone was isolated from Streptomyces sp. IFM11607 by cytotoxicity-guided fractionation against human gastric adenocarcinoma AGS cells, and the geometry of its Δ17,18-double bond was revised from E to Z based on the coupling constant.
ISSN:	1934-578X 1555-9475
DOI:	10.1177/1934578X1400900927