Effects of sitagliptin on counter-regulatory and incretin hormones during acute hypoglycaemia in patients with type 1 diabetes: a randomized double-blind placebo-controlled crossover study

Aims To assess whether the dipeptidyl peptidase‐4 (DPP‐4) inhibitor sitagliptin affects glucagon and other counter‐regulatory hormone responses to hypoglycaemia in patients with type 1 diabetes. Methods We conducted a single‐centre, randomized, double‐blind, placebo‐controlled, three‐period crossove...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2015-06, Vol.17 (6), p.546-553
Hauptverfasser:	Schopman, J. E., Hoekstra, J. B. L., Frier, B. M., Ackermans, M. T., de Sonnaville, J. J. J., Stades, A. M., Zwertbroek, R., Hartmann, B., Holst, J. J., Knop, F. K., Holleman, F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult counter-regulation Cross-Over Studies Diabetes Diabetes mellitus Diabetes mellitus (insulin dependent) Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - drug therapy dipeptidyl peptidase-4 Dipeptidyl-peptidase IV Dipeptidyl-Peptidase IV Inhibitors - pharmacology Double-Blind Method Double-blind studies Gastric Inhibitory Polypeptide - metabolism Glucagon Glucagon - drug effects Glucagon-Like Peptide 1 - metabolism glucagon-like peptide-1 glucose-dependent insulinotropic polypeptide Growth Hormone - drug effects Growth hormones Humans hypoglycaemia Hypoglycemia Hypoglycemia - blood Hypoglycemia - etiology incretin hormones Incretins - metabolism Male Medical research Middle Aged Patients Peptidase Sitagliptin Phosphate - pharmacology type 1 diabetes mellitus Young Adult
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