Association between an abnormal cerebroplacental ratio and the development of severe pre-eclampsia
Objective: To study the association between the cerebroplacental ratio (CPR) and the development of pre-eclampsia. Study Design: Three study groups were determined: Group 1—normal umbilical artery (UA; referent), Group 2—abnormal UA and normal CPR and Group 3—abnormal UA and an abnormal CPR. The pri...
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| Veröffentlicht in: | Journal of perinatology 2015-05, Vol.35 (5), p.322-327 |
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| creator | Regan, J Masters, H Warshak, C R |
| description | Objective:
To study the association between the cerebroplacental ratio (CPR) and the development of pre-eclampsia.
Study Design:
Three study groups were determined: Group 1—normal umbilical artery (UA; referent), Group 2—abnormal UA and normal CPR and Group 3—abnormal UA and an abnormal CPR. The primary outcome was the development of severe pre-eclampsia.
Results:
We included 270 women. Women in Group 3 had significantly elevated rates of severe pre-eclampsia versus those in Group 1 and Group 2, 52.5% versus 5.1% and 15.4%, respectively, (
P |
| doi_str_mv | 10.1038/jp.2014.210 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1676604193</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A413481858</galeid><sourcerecordid>A413481858</sourcerecordid><originalsourceid>FETCH-LOGICAL-c587t-2ee70c07024678605b165a38a050afed192d124404ec3e7189c6da21f946445c3</originalsourceid><addsrcrecordid>eNp90t1r1TAUAPAgDnedPvkuBUEE12u-kz5ehh-DgS_6HNL0dLeXNKlJO_G_N-VO3WSMBEJyfjlJyEHoFcFbgpn-cJi2FBO-pQQ_QRvClayF4Owp2mDFWa0Zl6foec4HjNegeoZOqeCKF7RB7S7n6AY7DzFULcw_AUJlS29DTKP1lYMEbYqTtw7CXBbSagvpqnkPVQc34OM0llgV-yqXaYJqSlCD83ac8mBfoJPe-gwvb8cz9P3Tx28XX-qrr58vL3ZXtRNazTUFUNhhhSmXSkssWiKFZdpigW0PHWloRyjnmINjoIhunOwsJX3DJefCsTP07ph3SvHHAnk245AdeG8DxCUbIpWUmJOGFfrmP3qISwrldoYyRiRVWDWPqTUX1pII-k9dWw9mCH2ck3Xr0WbHCeOaaKGL2j6gSutgHFwM0A9l_d6Gt3c27MH6eZ-jX9aPyvfh-yN0KeacoDdTGkabfhmCzVog5jCZtUBMKZCiX9--aWlH6P7aPxVRwPkR5BIK15DuPPqBfL8BaurANw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1676086152</pqid></control><display><type>article</type><title>Association between an abnormal cerebroplacental ratio and the development of severe pre-eclampsia</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Springer Nature - Complete Springer Journals</source><creator>Regan, J ; Masters, H ; Warshak, C R</creator><creatorcontrib>Regan, J ; Masters, H ; Warshak, C R</creatorcontrib><description>Objective:
To study the association between the cerebroplacental ratio (CPR) and the development of pre-eclampsia.
Study Design:
Three study groups were determined: Group 1—normal umbilical artery (UA; referent), Group 2—abnormal UA and normal CPR and Group 3—abnormal UA and an abnormal CPR. The primary outcome was the development of severe pre-eclampsia.
Results:
We included 270 women. Women in Group 3 had significantly elevated rates of severe pre-eclampsia versus those in Group 1 and Group 2, 52.5% versus 5.1% and 15.4%, respectively, (
P
<0.01), adjusted odds ratio 4.14 (95% confidence interval, 2.59 to 6.61). Kaplan–Meier analysis revealed earlier delivery in women with pre-eclampsia in Group 3 versus Group 1, Cox–Mantel hazard ratio 2.39 (1.17 to 4.88), log rank
P
=0.01.
Conclusion:
An abnormal CPR is associated with a higher rate severe pre-eclampsia with delivery at earlier gestational ages than with a normal UA or an abnormal UA, but normal CPR.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/jp.2014.210</identifier><identifier>PMID: 25474554</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>59 ; 692/308/409 ; Adult ; Analysis ; Blood flow ; Care and treatment ; Confidence intervals ; Diagnosis ; Female ; Fetal Growth Retardation - physiopathology ; Gestational Age ; Humans ; Infant, Newborn ; Kaplan-Meier Estimate ; Medicine ; Medicine & Public Health ; Middle Cerebral Artery - diagnostic imaging ; Mortality ; original-article ; Pediatric Surgery ; Pediatrics ; Pre-eclampsia ; Pre-Eclampsia - diagnosis ; Preeclampsia ; Pregnancy ; Pregnancy Outcome ; Regression Analysis ; Retrospective Studies ; Risk Factors ; Ultrasonography ; Umbilical Arteries - diagnostic imaging ; Young Adult</subject><ispartof>Journal of perinatology, 2015-05, Vol.35 (5), p.322-327</ispartof><rights>Nature America, Inc. 2015</rights><rights>COPYRIGHT 2015 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group May 2015</rights><rights>Nature America, Inc. 2015.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c587t-2ee70c07024678605b165a38a050afed192d124404ec3e7189c6da21f946445c3</citedby><cites>FETCH-LOGICAL-c587t-2ee70c07024678605b165a38a050afed192d124404ec3e7189c6da21f946445c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/jp.2014.210$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/jp.2014.210$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25474554$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Regan, J</creatorcontrib><creatorcontrib>Masters, H</creatorcontrib><creatorcontrib>Warshak, C R</creatorcontrib><title>Association between an abnormal cerebroplacental ratio and the development of severe pre-eclampsia</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective:
To study the association between the cerebroplacental ratio (CPR) and the development of pre-eclampsia.
Study Design:
Three study groups were determined: Group 1—normal umbilical artery (UA; referent), Group 2—abnormal UA and normal CPR and Group 3—abnormal UA and an abnormal CPR. The primary outcome was the development of severe pre-eclampsia.
Results:
We included 270 women. Women in Group 3 had significantly elevated rates of severe pre-eclampsia versus those in Group 1 and Group 2, 52.5% versus 5.1% and 15.4%, respectively, (
P
<0.01), adjusted odds ratio 4.14 (95% confidence interval, 2.59 to 6.61). Kaplan–Meier analysis revealed earlier delivery in women with pre-eclampsia in Group 3 versus Group 1, Cox–Mantel hazard ratio 2.39 (1.17 to 4.88), log rank
P
=0.01.
Conclusion:
An abnormal CPR is associated with a higher rate severe pre-eclampsia with delivery at earlier gestational ages than with a normal UA or an abnormal UA, but normal CPR.</description><subject>59</subject><subject>692/308/409</subject><subject>Adult</subject><subject>Analysis</subject><subject>Blood flow</subject><subject>Care and treatment</subject><subject>Confidence intervals</subject><subject>Diagnosis</subject><subject>Female</subject><subject>Fetal Growth Retardation - physiopathology</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Kaplan-Meier Estimate</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Cerebral Artery - diagnostic imaging</subject><subject>Mortality</subject><subject>original-article</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Pre-eclampsia</subject><subject>Pre-Eclampsia - diagnosis</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Regression Analysis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Ultrasonography</subject><subject>Umbilical Arteries - diagnostic imaging</subject><subject>Young Adult</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp90t1r1TAUAPAgDnedPvkuBUEE12u-kz5ehh-DgS_6HNL0dLeXNKlJO_G_N-VO3WSMBEJyfjlJyEHoFcFbgpn-cJi2FBO-pQQ_QRvClayF4Owp2mDFWa0Zl6foec4HjNegeoZOqeCKF7RB7S7n6AY7DzFULcw_AUJlS29DTKP1lYMEbYqTtw7CXBbSagvpqnkPVQc34OM0llgV-yqXaYJqSlCD83ac8mBfoJPe-gwvb8cz9P3Tx28XX-qrr58vL3ZXtRNazTUFUNhhhSmXSkssWiKFZdpigW0PHWloRyjnmINjoIhunOwsJX3DJefCsTP07ph3SvHHAnk245AdeG8DxCUbIpWUmJOGFfrmP3qISwrldoYyRiRVWDWPqTUX1pII-k9dWw9mCH2ck3Xr0WbHCeOaaKGL2j6gSutgHFwM0A9l_d6Gt3c27MH6eZ-jX9aPyvfh-yN0KeacoDdTGkabfhmCzVog5jCZtUBMKZCiX9--aWlH6P7aPxVRwPkR5BIK15DuPPqBfL8BaurANw</recordid><startdate>20150501</startdate><enddate>20150501</enddate><creator>Regan, J</creator><creator>Masters, H</creator><creator>Warshak, C R</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20150501</creationdate><title>Association between an abnormal cerebroplacental ratio and the development of severe pre-eclampsia</title><author>Regan, J ; Masters, H ; Warshak, C R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c587t-2ee70c07024678605b165a38a050afed192d124404ec3e7189c6da21f946445c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>59</topic><topic>692/308/409</topic><topic>Adult</topic><topic>Analysis</topic><topic>Blood flow</topic><topic>Care and treatment</topic><topic>Confidence intervals</topic><topic>Diagnosis</topic><topic>Female</topic><topic>Fetal Growth Retardation - physiopathology</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Kaplan-Meier Estimate</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Cerebral Artery - diagnostic imaging</topic><topic>Mortality</topic><topic>original-article</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Pre-eclampsia</topic><topic>Pre-Eclampsia - diagnosis</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Regression Analysis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Ultrasonography</topic><topic>Umbilical Arteries - diagnostic imaging</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Regan, J</creatorcontrib><creatorcontrib>Masters, H</creatorcontrib><creatorcontrib>Warshak, C R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Regan, J</au><au>Masters, H</au><au>Warshak, C R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between an abnormal cerebroplacental ratio and the development of severe pre-eclampsia</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2015-05-01</date><risdate>2015</risdate><volume>35</volume><issue>5</issue><spage>322</spage><epage>327</epage><pages>322-327</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>Objective:
To study the association between the cerebroplacental ratio (CPR) and the development of pre-eclampsia.
Study Design:
Three study groups were determined: Group 1—normal umbilical artery (UA; referent), Group 2—abnormal UA and normal CPR and Group 3—abnormal UA and an abnormal CPR. The primary outcome was the development of severe pre-eclampsia.
Results:
We included 270 women. Women in Group 3 had significantly elevated rates of severe pre-eclampsia versus those in Group 1 and Group 2, 52.5% versus 5.1% and 15.4%, respectively, (
P
<0.01), adjusted odds ratio 4.14 (95% confidence interval, 2.59 to 6.61). Kaplan–Meier analysis revealed earlier delivery in women with pre-eclampsia in Group 3 versus Group 1, Cox–Mantel hazard ratio 2.39 (1.17 to 4.88), log rank
P
=0.01.
Conclusion:
An abnormal CPR is associated with a higher rate severe pre-eclampsia with delivery at earlier gestational ages than with a normal UA or an abnormal UA, but normal CPR.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>25474554</pmid><doi>10.1038/jp.2014.210</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0743-8346 |
| ispartof | Journal of perinatology, 2015-05, Vol.35 (5), p.322-327 |
| issn | 0743-8346 1476-5543 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1676604193 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Springer Nature - Complete Springer Journals |
| subjects | 59 692/308/409 Adult Analysis Blood flow Care and treatment Confidence intervals Diagnosis Female Fetal Growth Retardation - physiopathology Gestational Age Humans Infant, Newborn Kaplan-Meier Estimate Medicine Medicine & Public Health Middle Cerebral Artery - diagnostic imaging Mortality original-article Pediatric Surgery Pediatrics Pre-eclampsia Pre-Eclampsia - diagnosis Preeclampsia Pregnancy Pregnancy Outcome Regression Analysis Retrospective Studies Risk Factors Ultrasonography Umbilical Arteries - diagnostic imaging Young Adult |
| title | Association between an abnormal cerebroplacental ratio and the development of severe pre-eclampsia |
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