Mixl1 and Flk1 Are Key Players of Wnt/TGF-β Signaling During DMSO-Induced Mesodermal Specification in P19 cells

Dimethyl sulfoxide (DMSO) is widely used to induce multilineage differentiation of embryonic and adult progenitor cells. To date, little is known about the mechanisms underlying DMSO‐induced mesodermal specification. In this study, we investigated the signaling pathways and lineage‐determining genes...

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Veröffentlicht in:	Journal of cellular physiology 2015-08, Vol.230 (8), p.1807-1821
Hauptverfasser:	Choi, Seung-Cheol, Choi, Ji-Hyun, Cui, Long-Hui, Seo, Ha-Rim, Kim, Jong-Ho, Park, Chi-Yeon, Joo, Hyung-Joon, Park, Jae-Hyoung, Hong, Soon-Jun, Yu, Cheol-Woong, Lim, Do-Sun
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Blotting, Western Cell Differentiation - drug effects Cell Differentiation - physiology Cell Line, Tumor Dimethyl Sulfoxide - pharmacology Embryoid Bodies - drug effects Embryoid Bodies - metabolism Embryonic Stem Cells - cytology Flow Cytometry Homeodomain Proteins - metabolism Humans Immunohistochemistry Mesoderm - cytology Mesoderm - drug effects Real-Time Polymerase Chain Reaction Transforming Growth Factor beta - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism Wnt Proteins - metabolism
Online-Zugang:	Volltext
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