Decreased expression of microRNA-206 correlates with poor clinical outcome in patients with malignant astrocytomas
MicroRNA-206 (miR-206) has been proved to function as a tumor suppressor in several types of human malignant cancers. More recently, it has been demonstrated that the ectopic expression of miR-206 significantly inhibited the proliferation and promoted apoptosis at the early stages in glioma cell U34...
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| Veröffentlicht in: | Pathology oncology research 2014-04, Vol.20 (2), p.343-348 |
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| creator | Wang, Shuai Lu, Shengkui Geng, Shaomei Ma, Shucheng Liang, Zhaohui Jiao, Baohua |
| description | MicroRNA-206 (miR-206) has been proved to function as a tumor suppressor in several types of human malignant cancers. More recently, it has been demonstrated that the ectopic expression of miR-206 significantly inhibited the proliferation and promoted apoptosis at the early stages in glioma cell U343. In order to investigate the clinical significance of miR-206 expression in human astrocytoma, quantitative real-time polymerase chain reaction (qRT-PCR) analysis was used to characterize the expression patterns of miR-206 in 108 astrocytoma and 20 normal brain tissues. As the results, the expression levels of miR-206 in astrocytoma tissues were significantly lower than those in normal brain tissues (
P
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| doi_str_mv | 10.1007/s12253-013-9701-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1676592315</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1676592315</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-597858f631239dbd5474b05dbd2fba3552359fe8055ab7dcc47ae45f50ad38903</originalsourceid><addsrcrecordid>eNp1kc1rFTEUxYMotj79A9xIwI2baD4nk2WpHy0UC0XXIZO5U1NmkjHJYPvfm8d7ighd5UJ-59zLOQi9ZvQ9o1R_KIxzJQhlghhNGemeoFOmBCe8p_ppmzkzRBrVnaAXpdzRpulM9xydcCkM7ak4Rfkj-AyuwIjhfs1QSkgRpwkvwed08_WMcNphn3KG2VUo-FeoP_CaUsZ-DjF4N-O0VZ8WwCHi1dUAsR6xxc3hNrpYsSs1J_9Q0-LKS_RscnOBV8d3h75__vTt_IJcXX-5PD-7Il5oXokyulf91AnGhRmHUUktB6raxKfBCaW4UGaCnirlBj16L7UDqSZF3Sh6Q8UOvTv4rjn93KBUu4TiYZ5dhLQVyzrdKcNFS2yH3v6H3qUtx3adZaql2Esp9xQ7UC2ZUjJMds1hcfnBMmr3hdhDIbYVYveF2K5p3hydt2GB8a_iTwMN4AegtK94C_mf1Y-6_gZUH5ZX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1512184445</pqid></control><display><type>article</type><title>Decreased expression of microRNA-206 correlates with poor clinical outcome in patients with malignant astrocytomas</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Wang, Shuai ; Lu, Shengkui ; Geng, Shaomei ; Ma, Shucheng ; Liang, Zhaohui ; Jiao, Baohua</creator><creatorcontrib>Wang, Shuai ; Lu, Shengkui ; Geng, Shaomei ; Ma, Shucheng ; Liang, Zhaohui ; Jiao, Baohua</creatorcontrib><description>MicroRNA-206 (miR-206) has been proved to function as a tumor suppressor in several types of human malignant cancers. More recently, it has been demonstrated that the ectopic expression of miR-206 significantly inhibited the proliferation and promoted apoptosis at the early stages in glioma cell U343. In order to investigate the clinical significance of miR-206 expression in human astrocytoma, quantitative real-time polymerase chain reaction (qRT-PCR) analysis was used to characterize the expression patterns of miR-206 in 108 astrocytoma and 20 normal brain tissues. As the results, the expression levels of miR-206 in astrocytoma tissues were significantly lower than those in normal brain tissues (
P
< 0.001). Additionally, the decreased expression of miR-206 in astrocytoma was significantly associated with advanced pathological grade (
P
= 0.008), low Karnofsky performance score (KPS,
P
= 0.02), and large tumor size (
P
= 0.01). Moreover, Kaplan-Meier survival and Cox regression analyses showed that low miR-206 expression (
P
< 0.001) and advanced pathological grade (
P
= 0.02) were independent factors predicting poor prognosis for astrocytomas. In conclusion, this is the first report of the differential expression of miR-206 in human astrocytoma tissues. MiR-206 could be a valuable marker of astrocytoma progression and low miR-206 expression is associated with poor overall survival in patients with malignant astrocytomas.</description><identifier>ISSN: 1219-4956</identifier><identifier>EISSN: 1532-2807</identifier><identifier>DOI: 10.1007/s12253-013-9701-6</identifier><identifier>PMID: 24390803</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Adolescent ; Adult ; Aged ; Astrocytoma - genetics ; Astrocytoma - pathology ; Biomarkers, Tumor - genetics ; Biomedical and Life Sciences ; Biomedicine ; Brain Neoplasms - genetics ; Brain Neoplasms - pathology ; Cancer Research ; Case-Control Studies ; Clinical outcomes ; Disease Progression ; Female ; Humans ; Immunology ; Kaplan-Meier Estimate ; Male ; MicroRNAs - genetics ; Middle Aged ; Oncology ; Pathology ; Prognosis ; Young Adult</subject><ispartof>Pathology oncology research, 2014-04, Vol.20 (2), p.343-348</ispartof><rights>Arányi Lajos Foundation 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-597858f631239dbd5474b05dbd2fba3552359fe8055ab7dcc47ae45f50ad38903</citedby><cites>FETCH-LOGICAL-c372t-597858f631239dbd5474b05dbd2fba3552359fe8055ab7dcc47ae45f50ad38903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12253-013-9701-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12253-013-9701-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24390803$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Shuai</creatorcontrib><creatorcontrib>Lu, Shengkui</creatorcontrib><creatorcontrib>Geng, Shaomei</creatorcontrib><creatorcontrib>Ma, Shucheng</creatorcontrib><creatorcontrib>Liang, Zhaohui</creatorcontrib><creatorcontrib>Jiao, Baohua</creatorcontrib><title>Decreased expression of microRNA-206 correlates with poor clinical outcome in patients with malignant astrocytomas</title><title>Pathology oncology research</title><addtitle>Pathol. Oncol. Res</addtitle><addtitle>Pathol Oncol Res</addtitle><description>MicroRNA-206 (miR-206) has been proved to function as a tumor suppressor in several types of human malignant cancers. More recently, it has been demonstrated that the ectopic expression of miR-206 significantly inhibited the proliferation and promoted apoptosis at the early stages in glioma cell U343. In order to investigate the clinical significance of miR-206 expression in human astrocytoma, quantitative real-time polymerase chain reaction (qRT-PCR) analysis was used to characterize the expression patterns of miR-206 in 108 astrocytoma and 20 normal brain tissues. As the results, the expression levels of miR-206 in astrocytoma tissues were significantly lower than those in normal brain tissues (
P
< 0.001). Additionally, the decreased expression of miR-206 in astrocytoma was significantly associated with advanced pathological grade (
P
= 0.008), low Karnofsky performance score (KPS,
P
= 0.02), and large tumor size (
P
= 0.01). Moreover, Kaplan-Meier survival and Cox regression analyses showed that low miR-206 expression (
P
< 0.001) and advanced pathological grade (
P
= 0.02) were independent factors predicting poor prognosis for astrocytomas. In conclusion, this is the first report of the differential expression of miR-206 in human astrocytoma tissues. MiR-206 could be a valuable marker of astrocytoma progression and low miR-206 expression is associated with poor overall survival in patients with malignant astrocytomas.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Astrocytoma - genetics</subject><subject>Astrocytoma - pathology</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - pathology</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>Clinical outcomes</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Humans</subject><subject>Immunology</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>MicroRNAs - genetics</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Pathology</subject><subject>Prognosis</subject><subject>Young Adult</subject><issn>1219-4956</issn><issn>1532-2807</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kc1rFTEUxYMotj79A9xIwI2baD4nk2WpHy0UC0XXIZO5U1NmkjHJYPvfm8d7ighd5UJ-59zLOQi9ZvQ9o1R_KIxzJQhlghhNGemeoFOmBCe8p_ppmzkzRBrVnaAXpdzRpulM9xydcCkM7ak4Rfkj-AyuwIjhfs1QSkgRpwkvwed08_WMcNphn3KG2VUo-FeoP_CaUsZ-DjF4N-O0VZ8WwCHi1dUAsR6xxc3hNrpYsSs1J_9Q0-LKS_RscnOBV8d3h75__vTt_IJcXX-5PD-7Il5oXokyulf91AnGhRmHUUktB6raxKfBCaW4UGaCnirlBj16L7UDqSZF3Sh6Q8UOvTv4rjn93KBUu4TiYZ5dhLQVyzrdKcNFS2yH3v6H3qUtx3adZaql2Esp9xQ7UC2ZUjJMds1hcfnBMmr3hdhDIbYVYveF2K5p3hydt2GB8a_iTwMN4AegtK94C_mf1Y-6_gZUH5ZX</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>Wang, Shuai</creator><creator>Lu, Shengkui</creator><creator>Geng, Shaomei</creator><creator>Ma, Shucheng</creator><creator>Liang, Zhaohui</creator><creator>Jiao, Baohua</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140401</creationdate><title>Decreased expression of microRNA-206 correlates with poor clinical outcome in patients with malignant astrocytomas</title><author>Wang, Shuai ; Lu, Shengkui ; Geng, Shaomei ; Ma, Shucheng ; Liang, Zhaohui ; Jiao, Baohua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-597858f631239dbd5474b05dbd2fba3552359fe8055ab7dcc47ae45f50ad38903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Astrocytoma - genetics</topic><topic>Astrocytoma - pathology</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain Neoplasms - genetics</topic><topic>Brain Neoplasms - pathology</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>Clinical outcomes</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Humans</topic><topic>Immunology</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>MicroRNAs - genetics</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Pathology</topic><topic>Prognosis</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Shuai</creatorcontrib><creatorcontrib>Lu, Shengkui</creatorcontrib><creatorcontrib>Geng, Shaomei</creatorcontrib><creatorcontrib>Ma, Shucheng</creatorcontrib><creatorcontrib>Liang, Zhaohui</creatorcontrib><creatorcontrib>Jiao, Baohua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Pathology oncology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Shuai</au><au>Lu, Shengkui</au><au>Geng, Shaomei</au><au>Ma, Shucheng</au><au>Liang, Zhaohui</au><au>Jiao, Baohua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased expression of microRNA-206 correlates with poor clinical outcome in patients with malignant astrocytomas</atitle><jtitle>Pathology oncology research</jtitle><stitle>Pathol. Oncol. Res</stitle><addtitle>Pathol Oncol Res</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>20</volume><issue>2</issue><spage>343</spage><epage>348</epage><pages>343-348</pages><issn>1219-4956</issn><eissn>1532-2807</eissn><abstract>MicroRNA-206 (miR-206) has been proved to function as a tumor suppressor in several types of human malignant cancers. More recently, it has been demonstrated that the ectopic expression of miR-206 significantly inhibited the proliferation and promoted apoptosis at the early stages in glioma cell U343. In order to investigate the clinical significance of miR-206 expression in human astrocytoma, quantitative real-time polymerase chain reaction (qRT-PCR) analysis was used to characterize the expression patterns of miR-206 in 108 astrocytoma and 20 normal brain tissues. As the results, the expression levels of miR-206 in astrocytoma tissues were significantly lower than those in normal brain tissues (
P
< 0.001). Additionally, the decreased expression of miR-206 in astrocytoma was significantly associated with advanced pathological grade (
P
= 0.008), low Karnofsky performance score (KPS,
P
= 0.02), and large tumor size (
P
= 0.01). Moreover, Kaplan-Meier survival and Cox regression analyses showed that low miR-206 expression (
P
< 0.001) and advanced pathological grade (
P
= 0.02) were independent factors predicting poor prognosis for astrocytomas. In conclusion, this is the first report of the differential expression of miR-206 in human astrocytoma tissues. MiR-206 could be a valuable marker of astrocytoma progression and low miR-206 expression is associated with poor overall survival in patients with malignant astrocytomas.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>24390803</pmid><doi>10.1007/s12253-013-9701-6</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adolescent Adult Aged Astrocytoma - genetics Astrocytoma - pathology Biomarkers, Tumor - genetics Biomedical and Life Sciences Biomedicine Brain Neoplasms - genetics Brain Neoplasms - pathology Cancer Research Case-Control Studies Clinical outcomes Disease Progression Female Humans Immunology Kaplan-Meier Estimate Male MicroRNAs - genetics Middle Aged Oncology Pathology Prognosis Young Adult |
| title | Decreased expression of microRNA-206 correlates with poor clinical outcome in patients with malignant astrocytomas |
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