Efficacy of bone marrow cytologic evaluations in detecting occult cancellous invasion
Objectives/Hypothesis Determine the accuracy of bone marrow cytologic evaluations in detecting occult cancellous invasion by squamous cell carcinomas (SCCa) beyond the original margins of bone resection that would have gone undetected without the use of intraoperative bone‐marrow margin analysis. St...
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| Veröffentlicht in: | The Laryngoscope 2015-05, Vol.125 (5), p.E173-E179 |
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| container_title | The Laryngoscope |
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| creator | Namin, Arya W. Bruggers, Seth D. Panuganti, Bharat A. Christopher, Kara M. Walker, Ronald J. Varvares, Mark A. |
| description | Objectives/Hypothesis
Determine the accuracy of bone marrow cytologic evaluations in detecting occult cancellous invasion by squamous cell carcinomas (SCCa) beyond the original margins of bone resection that would have gone undetected without the use of intraoperative bone‐marrow margin analysis.
Study Design
Retrospective single institution cohort study.
Methods
Retrospective chart review of imaging, clinical, pathological, and follow‐up data of 51 patients who underwent mandibular resections with intraoperative bone‐marrow cytologic evaluation. The accuracy of bone marrow cytologic evaluations to predict final bone margins was calculated. Five‐year survival rates were determined.
Results
The accuracy of bone marrow cytologic evaluations in detecting occult cancellous invasion by SCCa beyond the original margins of bone resection was 100%. Twelve percent (6/51) were found to have positive bone margins on cytology and were re‐resected to obtain clear margins. Patients with a prior history of radiation had a significantly higher incidence of initially positive bone‐marrow margins (P = 0.03). The patients with initially positive bone‐margins did not have a significantly different prognosis than the patients with initially negative bone‐marrow margins.
Conclusion
1) The consistent use of intraoperative bone‐marrow cytologic evaluation, when applicable, will improve the ability to obtain clear bone margins. 2) Patients with a history of prior radiation therapy have a significantly higher risk of having occult cancellous invasion of SCCa beyond the original margins of bone resection. 3) The prognosis of patients with initially positive bone‐marrow margins is not significantly different than patients with initially negative bone‐marrow margins.
Level of Evidence
4. Laryngoscope, 125:E173–E179, 2015 |
| doi_str_mv | 10.1002/lary.25063 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1676591131</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3666187941</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3953-f12251bc1ee6273bce60485e6dda49edd0b4065e1c35af9569dcd591999665083</originalsourceid><addsrcrecordid>eNp9kEtP3DAUhS1ExQxDN_yAyhIbhBRqx7EzXo4QrzIqtCqvbizHuRl5monBTqD59zgdYNEFq7u43zk6-hDapeSQEpJ-rbXvD1NOBNtAY8oZTTIp-SYaxydLpjy9G6HtEJaE0JxxsoVGKc-yXEgyRtfHVWWNNj12FS5cA3ilvXfP2PStq93CGgxPuu50a10TsG1wCS2Y1jYL7Izp6hYb3Rioa9cN7ycdIriDPlW6DvD59U7Q9cnxr6OzZH55en40myeGSc6SiqYpp4WhACLNWWFAkGzKQZSlziSUJSkyIjhQw7iuJBeyNCWXVEopBCdTNkH7694H7x47CK1a2TCM0Q3EPYqKXESeMhrRvf_Qpet8E9cNFJ9m2WBrgg7WlPEuBA-VevA2GukVJWqQrQbZ6p_sCH95reyKFZTv6JvdCNA18Gxr6D-oUvPZz_u30mSdsaGFv-8Z7f8okbOcq9vvp-qG_vh98e3qVqXsBYfmmSQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1675844002</pqid></control><display><type>article</type><title>Efficacy of bone marrow cytologic evaluations in detecting occult cancellous invasion</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Namin, Arya W. ; Bruggers, Seth D. ; Panuganti, Bharat A. ; Christopher, Kara M. ; Walker, Ronald J. ; Varvares, Mark A.</creator><creatorcontrib>Namin, Arya W. ; Bruggers, Seth D. ; Panuganti, Bharat A. ; Christopher, Kara M. ; Walker, Ronald J. ; Varvares, Mark A.</creatorcontrib><description>Objectives/Hypothesis
Determine the accuracy of bone marrow cytologic evaluations in detecting occult cancellous invasion by squamous cell carcinomas (SCCa) beyond the original margins of bone resection that would have gone undetected without the use of intraoperative bone‐marrow margin analysis.
Study Design
Retrospective single institution cohort study.
Methods
Retrospective chart review of imaging, clinical, pathological, and follow‐up data of 51 patients who underwent mandibular resections with intraoperative bone‐marrow cytologic evaluation. The accuracy of bone marrow cytologic evaluations to predict final bone margins was calculated. Five‐year survival rates were determined.
Results
The accuracy of bone marrow cytologic evaluations in detecting occult cancellous invasion by SCCa beyond the original margins of bone resection was 100%. Twelve percent (6/51) were found to have positive bone margins on cytology and were re‐resected to obtain clear margins. Patients with a prior history of radiation had a significantly higher incidence of initially positive bone‐marrow margins (P = 0.03). The patients with initially positive bone‐margins did not have a significantly different prognosis than the patients with initially negative bone‐marrow margins.
Conclusion
1) The consistent use of intraoperative bone‐marrow cytologic evaluation, when applicable, will improve the ability to obtain clear bone margins. 2) Patients with a history of prior radiation therapy have a significantly higher risk of having occult cancellous invasion of SCCa beyond the original margins of bone resection. 3) The prognosis of patients with initially positive bone‐marrow margins is not significantly different than patients with initially negative bone‐marrow margins.
Level of Evidence
4. Laryngoscope, 125:E173–E179, 2015</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.25063</identifier><identifier>PMID: 25447690</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Accuracy ; Aged ; Aged, 80 and over ; Bone marrow ; Bone Marrow Cells - pathology ; Bone Neoplasms - mortality ; Bone Neoplasms - pathology ; Bone Neoplasms - surgery ; cancellous bone ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - surgery ; cytologic evaluation ; cytology ; Female ; Follow-Up Studies ; frozen sections ; history of radiation ; Humans ; Male ; mandible ; Mandible - pathology ; Mandible - surgery ; mandibular invasion ; margins ; Medical prognosis ; Middle Aged ; Mouth Neoplasms - mortality ; Mouth Neoplasms - pathology ; Mouth Neoplasms - surgery ; Neoplasm Invasiveness ; Occult sciences ; Oral cancer ; Prognosis ; radiation ; Reproducibility of Results ; Retrospective Studies ; squamous cell carcinoma ; Survival Rate - trends ; Time Factors ; Transplants & implants ; United States - epidemiology</subject><ispartof>The Laryngoscope, 2015-05, Vol.125 (5), p.E173-E179</ispartof><rights>2014 The American Laryngological, Rhinological and Otological Society, Inc.</rights><rights>2015 The American Laryngological, Rhinological and Otological Society, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3953-f12251bc1ee6273bce60485e6dda49edd0b4065e1c35af9569dcd591999665083</citedby><cites>FETCH-LOGICAL-c3953-f12251bc1ee6273bce60485e6dda49edd0b4065e1c35af9569dcd591999665083</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.25063$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.25063$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1413,27906,27907,45556,45557</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25447690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Namin, Arya W.</creatorcontrib><creatorcontrib>Bruggers, Seth D.</creatorcontrib><creatorcontrib>Panuganti, Bharat A.</creatorcontrib><creatorcontrib>Christopher, Kara M.</creatorcontrib><creatorcontrib>Walker, Ronald J.</creatorcontrib><creatorcontrib>Varvares, Mark A.</creatorcontrib><title>Efficacy of bone marrow cytologic evaluations in detecting occult cancellous invasion</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objectives/Hypothesis
Determine the accuracy of bone marrow cytologic evaluations in detecting occult cancellous invasion by squamous cell carcinomas (SCCa) beyond the original margins of bone resection that would have gone undetected without the use of intraoperative bone‐marrow margin analysis.
Study Design
Retrospective single institution cohort study.
Methods
Retrospective chart review of imaging, clinical, pathological, and follow‐up data of 51 patients who underwent mandibular resections with intraoperative bone‐marrow cytologic evaluation. The accuracy of bone marrow cytologic evaluations to predict final bone margins was calculated. Five‐year survival rates were determined.
Results
The accuracy of bone marrow cytologic evaluations in detecting occult cancellous invasion by SCCa beyond the original margins of bone resection was 100%. Twelve percent (6/51) were found to have positive bone margins on cytology and were re‐resected to obtain clear margins. Patients with a prior history of radiation had a significantly higher incidence of initially positive bone‐marrow margins (P = 0.03). The patients with initially positive bone‐margins did not have a significantly different prognosis than the patients with initially negative bone‐marrow margins.
Conclusion
1) The consistent use of intraoperative bone‐marrow cytologic evaluation, when applicable, will improve the ability to obtain clear bone margins. 2) Patients with a history of prior radiation therapy have a significantly higher risk of having occult cancellous invasion of SCCa beyond the original margins of bone resection. 3) The prognosis of patients with initially positive bone‐marrow margins is not significantly different than patients with initially negative bone‐marrow margins.
Level of Evidence
4. Laryngoscope, 125:E173–E179, 2015</description><subject>Accuracy</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone marrow</subject><subject>Bone Marrow Cells - pathology</subject><subject>Bone Neoplasms - mortality</subject><subject>Bone Neoplasms - pathology</subject><subject>Bone Neoplasms - surgery</subject><subject>cancellous bone</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>cytologic evaluation</subject><subject>cytology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>frozen sections</subject><subject>history of radiation</subject><subject>Humans</subject><subject>Male</subject><subject>mandible</subject><subject>Mandible - pathology</subject><subject>Mandible - surgery</subject><subject>mandibular invasion</subject><subject>margins</subject><subject>Medical prognosis</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - mortality</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mouth Neoplasms - surgery</subject><subject>Neoplasm Invasiveness</subject><subject>Occult sciences</subject><subject>Oral cancer</subject><subject>Prognosis</subject><subject>radiation</subject><subject>Reproducibility of Results</subject><subject>Retrospective Studies</subject><subject>squamous cell carcinoma</subject><subject>Survival Rate - trends</subject><subject>Time Factors</subject><subject>Transplants & implants</subject><subject>United States - epidemiology</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtP3DAUhS1ExQxDN_yAyhIbhBRqx7EzXo4QrzIqtCqvbizHuRl5monBTqD59zgdYNEFq7u43zk6-hDapeSQEpJ-rbXvD1NOBNtAY8oZTTIp-SYaxydLpjy9G6HtEJaE0JxxsoVGKc-yXEgyRtfHVWWNNj12FS5cA3ilvXfP2PStq93CGgxPuu50a10TsG1wCS2Y1jYL7Izp6hYb3Rioa9cN7ycdIriDPlW6DvD59U7Q9cnxr6OzZH55en40myeGSc6SiqYpp4WhACLNWWFAkGzKQZSlziSUJSkyIjhQw7iuJBeyNCWXVEopBCdTNkH7694H7x47CK1a2TCM0Q3EPYqKXESeMhrRvf_Qpet8E9cNFJ9m2WBrgg7WlPEuBA-VevA2GukVJWqQrQbZ6p_sCH95reyKFZTv6JvdCNA18Gxr6D-oUvPZz_u30mSdsaGFv-8Z7f8okbOcq9vvp-qG_vh98e3qVqXsBYfmmSQ</recordid><startdate>201505</startdate><enddate>201505</enddate><creator>Namin, Arya W.</creator><creator>Bruggers, Seth D.</creator><creator>Panuganti, Bharat A.</creator><creator>Christopher, Kara M.</creator><creator>Walker, Ronald J.</creator><creator>Varvares, Mark A.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201505</creationdate><title>Efficacy of bone marrow cytologic evaluations in detecting occult cancellous invasion</title><author>Namin, Arya W. ; Bruggers, Seth D. ; Panuganti, Bharat A. ; Christopher, Kara M. ; Walker, Ronald J. ; Varvares, Mark A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3953-f12251bc1ee6273bce60485e6dda49edd0b4065e1c35af9569dcd591999665083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Accuracy</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone marrow</topic><topic>Bone Marrow Cells - pathology</topic><topic>Bone Neoplasms - mortality</topic><topic>Bone Neoplasms - pathology</topic><topic>Bone Neoplasms - surgery</topic><topic>cancellous bone</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - surgery</topic><topic>cytologic evaluation</topic><topic>cytology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>frozen sections</topic><topic>history of radiation</topic><topic>Humans</topic><topic>Male</topic><topic>mandible</topic><topic>Mandible - pathology</topic><topic>Mandible - surgery</topic><topic>mandibular invasion</topic><topic>margins</topic><topic>Medical prognosis</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - mortality</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mouth Neoplasms - surgery</topic><topic>Neoplasm Invasiveness</topic><topic>Occult sciences</topic><topic>Oral cancer</topic><topic>Prognosis</topic><topic>radiation</topic><topic>Reproducibility of Results</topic><topic>Retrospective Studies</topic><topic>squamous cell carcinoma</topic><topic>Survival Rate - trends</topic><topic>Time Factors</topic><topic>Transplants & implants</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Namin, Arya W.</creatorcontrib><creatorcontrib>Bruggers, Seth D.</creatorcontrib><creatorcontrib>Panuganti, Bharat A.</creatorcontrib><creatorcontrib>Christopher, Kara M.</creatorcontrib><creatorcontrib>Walker, Ronald J.</creatorcontrib><creatorcontrib>Varvares, Mark A.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Namin, Arya W.</au><au>Bruggers, Seth D.</au><au>Panuganti, Bharat A.</au><au>Christopher, Kara M.</au><au>Walker, Ronald J.</au><au>Varvares, Mark A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of bone marrow cytologic evaluations in detecting occult cancellous invasion</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2015-05</date><risdate>2015</risdate><volume>125</volume><issue>5</issue><spage>E173</spage><epage>E179</epage><pages>E173-E179</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract>Objectives/Hypothesis
Determine the accuracy of bone marrow cytologic evaluations in detecting occult cancellous invasion by squamous cell carcinomas (SCCa) beyond the original margins of bone resection that would have gone undetected without the use of intraoperative bone‐marrow margin analysis.
Study Design
Retrospective single institution cohort study.
Methods
Retrospective chart review of imaging, clinical, pathological, and follow‐up data of 51 patients who underwent mandibular resections with intraoperative bone‐marrow cytologic evaluation. The accuracy of bone marrow cytologic evaluations to predict final bone margins was calculated. Five‐year survival rates were determined.
Results
The accuracy of bone marrow cytologic evaluations in detecting occult cancellous invasion by SCCa beyond the original margins of bone resection was 100%. Twelve percent (6/51) were found to have positive bone margins on cytology and were re‐resected to obtain clear margins. Patients with a prior history of radiation had a significantly higher incidence of initially positive bone‐marrow margins (P = 0.03). The patients with initially positive bone‐margins did not have a significantly different prognosis than the patients with initially negative bone‐marrow margins.
Conclusion
1) The consistent use of intraoperative bone‐marrow cytologic evaluation, when applicable, will improve the ability to obtain clear bone margins. 2) Patients with a history of prior radiation therapy have a significantly higher risk of having occult cancellous invasion of SCCa beyond the original margins of bone resection. 3) The prognosis of patients with initially positive bone‐marrow margins is not significantly different than patients with initially negative bone‐marrow margins.
Level of Evidence
4. Laryngoscope, 125:E173–E179, 2015</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25447690</pmid><doi>10.1002/lary.25063</doi><tpages>7</tpages></addata></record> |
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| subjects | Accuracy Aged Aged, 80 and over Bone marrow Bone Marrow Cells - pathology Bone Neoplasms - mortality Bone Neoplasms - pathology Bone Neoplasms - surgery cancellous bone Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - surgery cytologic evaluation cytology Female Follow-Up Studies frozen sections history of radiation Humans Male mandible Mandible - pathology Mandible - surgery mandibular invasion margins Medical prognosis Middle Aged Mouth Neoplasms - mortality Mouth Neoplasms - pathology Mouth Neoplasms - surgery Neoplasm Invasiveness Occult sciences Oral cancer Prognosis radiation Reproducibility of Results Retrospective Studies squamous cell carcinoma Survival Rate - trends Time Factors Transplants & implants United States - epidemiology |
| title | Efficacy of bone marrow cytologic evaluations in detecting occult cancellous invasion |
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