Systemic 3-nitropropionic acid: Behavioral deficits and striatal damage in adult rats

Previous animal studies have demonstrated that systemic administration of 3-nitropropfonic acid 3-NP) leads to neuropathological changes similar to those seen in Huntington's disease (HD). Recently, we reported hypeactivity in 6- and 10-week old rats treated with systemic 3-NP OP, 10 mg/kg/day)...

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Veröffentlicht in:	Brain research bulletin 1995, Vol.36 (6), p.549-556
Hauptverfasser:	Borlongan, C.V., Koutouzis, T.K., Randall, T.S., Freeman, T.B., Cahill, D.W., Sanberg, P.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-nitropropionic acid Animals Avoidance Learning - drug effects Behavior, Animal - drug effects Biological and medical sciences Corpus Striatum - drug effects Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Histocytochemistry Huntington Disease - pathology Huntington's disease Injections, Intraperitoneal Locomotion Male Medical sciences Motor Activity - drug effects Neurodegeneration Neurology Neurons - drug effects Neurons - pathology Nitro Compounds Pain Threshold Passive avoidance Propionates - toxicity Rats Rats, Sprague-Dawley Staining and Labeling
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