A dopamine-responsive domain in the N-terminal sequence of Pit-1. Transcriptional inhibition in endocrine cell types

The POU transcription factor Pit-1 activates the prolactin gene in pituitary lactotrophs and may integrate responses of the gene to external signals. To study the role of Pit-1 in dopaminergic inhibition of the prolactin gene, we transiently transfected Pit-1 and dopamine D2 receptor vectors into a...

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Veröffentlicht in:	The Journal of biological chemistry 1995-03, Vol.270 (13), p.7156-7160
Hauptverfasser:	Lew, A M, Elsholtz, H P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - metabolism Cell Line Chlorocebus aethiops DNA-Binding Proteins - biosynthesis DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Dopamine - pharmacology Fibroblasts Islets of Langerhans Kidney Luciferases - biosynthesis Muscles Pituitary Gland Prolactin - biosynthesis Promoter Regions, Genetic - drug effects Rats Receptors, Dopamine D2 - biosynthesis Receptors, Dopamine D2 - metabolism Recombinant Fusion Proteins - biosynthesis Recombinant Fusion Proteins - metabolism Serine Endopeptidases Transcription Factor Pit-1 Transcription Factors - biosynthesis Transcription Factors - chemistry Transcription Factors - metabolism Transcription, Genetic - drug effects Transfection
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